Results 81 to 90 of about 5,533 (240)
Emerging perspectives on laminopathies
Cell Health and Cytoskeleton, 2016 Laminopathies are a group of inherited disorders caused by mutations in the lamin A/C gene, and can affect diverse organs or tissues, or can be systemic, causing premature aging. In the present review, we report on the composition and structure of the nuclear lamina and the role of lamins in nuclear mechanics and their involvement in human diseases ...
Lattanzi, Giovanna +6 more
openaire +5 more sources
Nuclear envelope proteins and chromatin arrangement: a pathogenic mechanism for laminopathies
European Journal of Histochemistry, 2009 The involvement of the nuclear envelope in the modulation of chromatin organization is strongly suggested by the increasing number of human diseases due to mutations of nuclear envelope proteins.
NM Maraldi +6 more
doaj +1 more source
Les lipodystrophies secondaires aux traitements antirétroviraux de l’infection par le VIH [PDF]
, 2006 Les traitements antirétroviraux de l’infection par le VIH sont responsables d’effets secondaires parfois sévères qui touchent en priorité le tissu adipeux, modifiant sa localisation (lipodystrophie avec lipoatrophie périphérique et hypertrophie centrale)
Bastard, Jean-Philippe +7 more
core +2 more sources
Aging and Altered Gravity: A Cellular Perspective
The FASEB Journal, Volume 39, Issue 13, 15 July 2025.We propose that, unlike biological aging, where Primary hallmarks initiate damage, spaceflight may trigger a feedback loop between Antagonistic and Integrative hallmarks, driving accelerated aging. Returning to 1 g restores proper signaling and breaks the cycle.
Sharon van Rijthoven +1 more
wiley +1 more source
Cardiac involvement in laminopathies [PDF]
Orphanet Journal of Rare Diseases, 2015 Lamin A/C gene mutations can be associated with myocardial diseases, usually characterized by dilated cardiomyopathy and/or arrhythmic disorders. Phenotypic penetrance is age-related but expression is extremely heterogeneous, so that muscular and arrhythmic disease can be present in combination in the same patient, or one phenotypic manifestation can ...
Boriani, Giuseppe +3 more
openaire +1 more source
Identification of Genes and Pathways Regulated by Lamin A in Heart
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020 Background Mutations in the LMNA gene, encoding LMNA (lamin A/C), causes distinct disorders, including dilated cardiomyopathies, collectively referred to as laminopathies. The genes (coding and noncoding) and regulatory pathways controlled by LMNA in the
Jordi Coste Pradas +13 more
doaj +1 more source
Nanoscale Curvature Regulates YAP/TAZ Nuclear Localization Through Nuclear Deformation and Rupture
Advanced Science, Volume 12, Issue 28, July 24, 2025.This study uses experiments and biophysical modeling to examine the response and adaptation of cells to nanoscale topography of surfaces. It is shown that cytoskeletal assembly and nuclear localization of transcription regulatory factors such as yes‐associated protein (YAP) and transcriptional coactivator with PDZ‐binding motif (TAZ) can be tuned by ...
Emmet A. Francis +7 more
wiley +1 more source
Nuclear Organization in Stress and Aging
Cells, 2019 The eukaryotic nucleus controls most cellular processes. It is isolated from the cytoplasm by the nuclear envelope, which plays a prominent role in the structural organization of the cell, including nucleocytoplasmic communication, chromatin positioning,
Raquel Romero-Bueno +4 more
doaj +1 more source
From lamins to lamina: a structural perspective [PDF]
, 2018 Lamin proteins are the major constituents of the nuclear lamina, a proteinaceous network that lines the inner nuclear membrane. Primarily, the nuclear lamina provides structural support for the nucleus and the nuclear envelope; however, lamins and their ...
Medalia, Ohad, Zwerger, Monika
core
Myonuclear alterations associated with exercise are independent of age in humans
The Journal of Physiology, Volume 603, Issue 13, Page 3755-3775, 1 July 2025.Abstract figure legend Structural and mechanical properties of myonuclei in trained young and aged individuals. In skeletal muscle fibres from trained individuals, myonuclei are more spherical, have greater lamin A and are stiffer compared to untrained counterparts.
E. Battey +15 more
wiley +1 more source