Results 91 to 100 of about 129 (128)

Porphyromonas gingivalis GroEL exacerbates orthotopic allograft transplantation vasculopathy via impairment of endothelial cell function

Molecular Oral Microbiology, EarlyView.
Abstract Orthotopic allograft transplantation (OAT) is a significant approach to addressing organ failure. However, persistent immune responses to the allograft affect chronic rejection, which induces OAT vasculopathy (OATV) and organ failure. Porphyromonas gingivalis can infiltrate remote organs via the bloodstream, thereby intensifying the severity ...
Chien‐Sung Tsai, Chun‐Yao Huang, Yi‐Ting Tsai, Chun‐Ming Shih, Ze‐Hao Lai, Chen‐Wei Liu, Yi‐Wen Lin, Feng‐Yen Lin   +7 more
wiley   +1 more source

ERF100 regulated by ERF28 and NOR controls pectate lyase 7, modulating fig (Ficus carica L.) fruit softening

Plant Biotechnology Journal, EarlyView.
Summary The mechanism regulating fruit textural changes has not been fully elucidated. Transcription factor FcERF100 showed rapid transcription repression during drastic texture loss in fig (Ficus carica L.) fruit ripening. Transient overexpression of FcERF100 delayed fig fruit softening and significantly decreased the transcript abundance of a key ...
Zhiyi Fan, Yuan Wang, Yanlei Zhai, Xiaojiao Gu, Kairong Sun, Dan Zhao, Jinying Wang, Pinqi Sun, Hantang Huang, Jiajun He, Yining Wang, Moshe A. Flaishman, Huiqin Ma   +12 more
wiley   +1 more source

R&D investments in knowledge intensive sectors in developing countries and the role of host country political uncertainty

R&D Management, Volume 55, Issue 3, Page 873-898, June 2025.
Multinational enterprises (MNEs) persistently navigate environments characterized by political uncertainty. Yet, it is unclear how such uncertainty affects the location and sectoral spread of MNEs' overseas research and development (R&D) investments.
Evis Sinani, Bernhard Dachs, Bersant Hobdari, Marina Papanastassiou   +3 more
wiley   +1 more source

Early genetic screening and cardiac intervention in patients with cardiomyopathies in a multidisciplinary clinic

ESC Heart Failure, Volume 12, Issue 3, Page 1942-1955, June 2025.
Abstract Aims Patients with cardiomyopathies are a heterogeneous group of patients who experience high morbidity and mortality. Early cardiac assessment and intervention with access to genetic counselling in a multidisciplinary Cardiomyopathy Clinic may improve outcomes and prevent progression to advanced heart failure.
Chandu Sadasivan, Luke R. Gagnon, Deepan Hazra, Kaiming Wang, Erik Youngson, Jissy Thomas, Anita Y.M. Chan, D. Ian Paterson, Finlay A. McAlister, Tara Dzwiniel, Wayne Tymchak, Susan Christian, Gavin Y. Oudit   +12 more
wiley   +1 more source

The Long Noncoding RNA LINC02820 Promotes Tumor Growth and Metastasis Through Regulating MYH9 Expression in Esophageal Squamous Cell Carcinoma

MedComm, Volume 6, Issue 6, June 2025.
This study demonstrates that the RNA‐binding protein IGF2BP2 binds to and stabilizes LINC02820, leading to elevated LINC02820 expression in esophageal squamous cell carcinoma (ESCC). Moreover, association of LINC02820 with MYH9 protein protects MYH9 from proteasomal degradation, thus upregulating MYH9 to promote tumor growth and metastasis in ESCC ...
Xiaomin Xu, Xinting Mao, Wenrong Liu, Yue Ming, Tingting Zhang, Yang Yang, A‐Lai Gu‐Ha, Yi‐Dan Lin, Yong Peng   +8 more
wiley   +1 more source

Maintaining the Integral Membrane Proteome: Revisiting the Functional Repertoire of Integral Membrane Proteases

ChemBioChem, Volume 26, Issue 9, May 5, 2025.
Regulated intramembrane proteolysis is crucial for functional proteome in all kingdoms of life. The task of cleaving transmembrane proteins within the unique environment of the lipid bilayer presents biochemical challenges that has been solved by integral membrane proteases (IMPRs).
Hannah Fremlén, Björn M. Burmann
wiley   +1 more source

Genetic cardiomyopathy mimicking isolated cardiac sarcoidosis: Diagnostic challenges with positron emission tomography

ESC Heart Failure, Volume 12, Issue 3, Page 2347-2352, June 2025.
Daigo Nishijo, Shunsuke Inoue, Zhehao Dai, Seitaro Nomura, Ryo Abe, Takashi Hiruma, Chie Bujo, Tsukasa Oshima, Manami Katoh, Yu Shimizu, Masamichi Ito, Kenichiro Yamagata, Junichi Ishida, Eisuke Amiya, Norifumi Takeda, Katsuhito Fujiu, Masaru Hatano, Hiroyuki Morita, Norihiko Takeda, Issei Komuro   +19 more
wiley   +1 more source

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Laminitis in the horse

Veterinary Record, 1977
Much has been written on laminitis and its treatment over the past 200 years. This article makes a brief review of the practical essentials of the disease and considers some of the recent trends in therapy. Knowledge of the pathogenesis and aetiology of equine laminitis is still very incomplete but recent work in the United States by Coffman and his ...
LB Jeffcott, CM Colles
openaire   +3 more sources

Laminating the hippocampus [PDF]

Nature Reviews Neuroscience, 2006
Lamination of neurons and fibre projections is a fundamental organizational principle of the mammalian cerebral cortex. A laminated organization is likely to be essential for cortical function, as studies in mutant mice have revealed causal relationships between lamination defects and functional deficits.
Förster, Eckart, Zhao, Shanting, Frotscher, Michael   +2 more
openaire   +3 more sources

Hyperinsulinemic Laminitis

Veterinary Clinics of North America: Equine Practice, 2010
Laminitis occurring in association with hyperinsulinemia is frequently encountered in today's equine population. New evidence suggests that hyperinsulinemia is the direct cause of this form of laminitis, rather than insulin resistance per se. The mechanism by which elevated serum insulin concentrations result in lamellar dysfunction is currently under ...
de Laat, Melody A., McGowan, Catherine M., Sillence, Martin N., Pollitt, Christopher C.   +3 more
openaire   +3 more sources