Vimentin filaments are assembled from a soluble precursor in avian erythroid cells [PDF]
, 1983 The synthesis and assembly of vimentin was studied in erythroid cells from 10-d-old chicken embryos. After various periods of [35S]methionine incorporation, cells were lysed in a Triton X-100-containing buffer and separated into a soluble and an ...
Blikstad, Ingrid, Lazarides, Elias
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Quantitative Analysis of Nuclear Lamins Imaged by Super-Resolution Light Microscopy
Cells, 2019 The nuclear lamina consists of a dense fibrous meshwork of nuclear lamins, Type V intermediate filaments, and is ~14 nm thick according to recent cryo-electron tomography studies.
Mark Kittisopikul +3 more
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Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution [PDF]
, 1995 Although specific proteinases play a critical role in the active phase of apoptosis, their substrates are largely unknown. We previously identified poly(ADP-ribose) polymerase (PARP) as an apoptosis-associated substrate for proteinase(s) related to ...
Earnshaw, W. C. +6 more
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Microtubular and Nuclear Functions of γ-Tubulin: Are They LINCed?
Cells, 2019 γ-Tubulin is a conserved member of the tubulin superfamily with a function in microtubule nucleation. Proteins of γ-tubulin complexes serve as nucleation templates as well as a majority of other proteins contributing to centrosomal and non ...
Jana Chumová +4 more
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Expression of proliferation-dependent antigens during cellular ageing of normal and progeroid human fibroblasts [PDF]
, 1994 Normal human fibroblasts display a limited lifespan in culture, which is due to a steadily decreasing fraction of cells that are able to proliferate.
Faragher, RA +3 more
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Nesprin-2-dependent ERK1/2 compartmentalisation regulates the DNA damage response in vascular smooth muscle cell ageing [PDF]
, 2015 Prelamin A accumulation and persistent DNA damage response (DDR) are hallmarks of vascular smooth muscle cell (VSMC) ageing and dysfunction. Although prelamin A is proposed to interfere with DNA repair, our understanding of the crosstalk between prelamin
Cobb, A. +8 more
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The cell nucleus. A study in Burgundy
Nucleus, 2019 Wilhelm Bernhard’s revolutionary microscopy techniques helped him put forward the hypothesis of specialized compartmentalization of the nucleus. He also described for the first time the nuclear bodies and peri-chromatin fibrils, and demonstrated that ...
Oleg Demidov +3 more
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Frontiers in Cell and Developmental Biology, 2019 DYT1 dystonia is a neurological movement disorder that is caused by a loss-of-function mutation in the DYT1/TOR1A gene, which encodes torsinA, a conserved luminal ATPases-associated with various cellular activities (AAA+) protein. TorsinA is required for
Navjot Kaur Gill +11 more
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Multilevel analysis of nuclear dynamics in lamin perturbed fibroblasts [PDF]
, 2010 The nuclear lamina provides structural support to the nucleus and has a central role in defining nuclear organization. Defects in its filamentous constituents, the lamins, lead to a class of diseases collectively referred to as laminopathies.
Broers, Jos +7 more
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Hierarchical coexistence of universality and diversity controls robustness and multi-functionality in intermediate filament protein networks [PDF]
, 2007 Proteins constitute the elementary building blocks of a vast variety of biological materials such as cellular protein networks, spider silk or bone, where they create extremely robust, multi-functional materials by self-organization of structures over ...
Markus J. Buehler, Theodor Ackbarow
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