Results 81 to 90 of about 18,044 (328)

Regulating the levels of key factors in cell cycle and DNA repair: New pathways revealed by lamins [PDF]

, 2011
Spatial and temporal organization of the genome represents an additional step in the regulation of nuclear functions. The nuclear lamina, a polymeric meshwork formed by lamins (A/C and B type) and lamin-associated proteins, plays a key role in the ...
Gonzalez-Suarez, Ignacio, Gonzalo, Susana, Redwood, Abena B   +2 more
core   +2 more sources

Bounding laminations

Duke Mathematical Journal, 1988
Consider a hyperbolic surface S, bounding a 3-dimensional handlebody V (or, more generally, a compression body). A geodesic lamination on S is a closed union of disjoint simple geodesics. The article is concerned with the following question: When is such a lamination the Hausdorff limit of a sequence of simple closed geodesics which are homotopic to 0 ...
openaire   +3 more sources

An Injection‐Molded Modified Silicone Rubber for Cancer‐on‐Chip Applications

Advanced Materials Technologies, Volume 10, Issue 6, March 18, 2025.
This study describes the characterization and application of an injection‐molded functionalized PDMS fluidic insert for the commercially available Micronit system. Modified PDMS can accommodate cell culture and is able to covalently bind proteins for long‐lasting coatings under flow‐conditions.
Ben J. Haspels, Frederikus Bakker, Lucas J. A. M. Beckers, Roland Kanaar, Koen C. Kriege, Susanne M. Valster, Roland C. M. Vulders, Maayke M. P. Kuijten   +7 more
wiley   +1 more source

Internal iamin structures within G1 nuclei of human dermal fibroblasts [PDF]

, 1993
The nuclear lamina is a mesh-like network of fibres subjacent to the inner nuclear membrane that is believed to be involved in the specific spatial reorganisation of chromatin after mitosis.
Bridger, JM, Hutchison, CJ, Kill, IR, O’Farrell, M   +3 more
core  

Altered modulation of lamin A/C-HDAC2 interaction and p21 expression during oxidative stress response in HGPS [PDF]

, 2018
Defects in stress response are main determinants of cellular senescence and organism aging. In fibroblasts from patients affected by Hutchinson-Gilford progeria, a severe LMNA-linked syndrome associated with bone resorption, cardiovascular disorders, and
Andrenacci, Davide, Cicchilitti, Lucia, Di Blasio, Anna Maria, Garofalo, Cecilia, Gentilini, Davide, Lattanzi, Giovanna, Mai, Antonello, Mattioli, Elisabetta, Piaggio, Giulia, Prencipe, Sabino, Remondini, Daniel, Scarano, Emanuela, Scotlandi, Katia, Valente, Sergio   +13 more
core   +2 more sources

Laminate Veneerler

Selcuk Dental Journal, 2022
Laminate Veneerler Estetik dental tedavilerde hastaların beklenti ve gereksinimleri günden güne artmaktadır. Dental estetik, hastaların kaybettikleri estetik görüntünün yeniden kazandırılmasında son derece önemli bir yer tutmaktadır. Hasta beklentilerinin bu denli yüksek olması, hekimleri tedavilerde daha estetik materyaller kullanmaya ve daha hassas ...
Emre SİVA, Hakan TERZİOGLU
openaire   +3 more sources

Topoisomerase I Inhibition in ETV4‐overexpressed Non‐Small Cell Lung Cancer Promotes Replication and Transcription Mediated R‐Loop Accumulation and DNA Damage

Advanced Science, EarlyView.
The oncogenic ETS factor ETV4 exerts a pleiotropic control over DNA replication both in a transcription‐dependent and ‐independent fashion in NSCLC cells. High‐ETV4 expression leads to R‐loop formation and DNA damage in response to TOP1 inhibition.
Jiaxi Zhang, Yan Wang, Shanhu Cao, Shelly M. Xie, Bei Liu, Yimeng Li, Yuqi Hou, Xue Meng, Mingzhu Ruan, Di Bu, Jia Kang, Ruxin Li, Lei Lou, Juan Wang, Lingxiao Xing   +14 more
wiley   +1 more source

The Role of Lamins in the Nucleoplasmic Reticulum, a Pleiomorphic Organelle That Enhances Nucleo-Cytoplasmic Interplay

Frontiers in Cell and Developmental Biology, 2022
Invaginations of the nuclear membrane occur in different shapes, sizes, and compositions. Part of these pleiomorphic invaginations make up the nucleoplasmic reticulum (NR), while others are merely nuclear folds.
Merel Stiekema, Merel Stiekema, Frederik Houben, Frederik Houben, Fons Verheyen, Marcel Borgers, Julia Menzel, Martin Meschkat, Marc A. M. J. van Zandvoort, Marc A. M. J. van Zandvoort, Marc A. M. J. van Zandvoort, Marc A. M. J. van Zandvoort, Frans C. S. Ramaekers, Frans C. S. Ramaekers, Jos L. V. Broers, Jos L. V. Broers, Jos L. V. Broers   +16 more
doaj   +1 more source

Nuclear Lamins [PDF]

Cold Spring Harbor Perspectives in Biology, 2010
The nuclear lamins are type V intermediate filament proteins that are critically important for the structural properties of the nucleus. In addition, they are involved in the regulation of numerous nuclear processes, including DNA replication, transcription and chromatin organization.
Thomas, Dechat, Stephen A, Adam, Pekka, Taimen, Takeshi, Shimi, Robert D, Goldman   +4 more
openaire   +2 more sources

METTL14‐Mediated M6A Modification of LINC01094 Induces Glucose Metabolic Reprogramming in Breast Cancer by Recruiting the PKM2/JMJD5 Complex

Advanced Science, EarlyView.
METTL14/IGF2BP2‐mediated m6A modification drives LINC01094 upregulation in BC. Then, LINC01094 interacts with PKM2 monomers to promote their dimerization, while serving as a flexible scaffold to facilitate the assembly of the PKM2/JMJD5 complex, synergistically stabilizing PKM2 dimers and enhancing their nuclear translocation.
Mengqi Wang, Zhaoxin Gao, Ruinan Zhao, Pan Zhou, Jingxi Chen, Hui Zhang, Yawen Wang, Wenjie Zhu, Peng Gao   +8 more
wiley   +1 more source