Results 161 to 170 of about 18,858 (196)
Some of the next articles are maybe not open access.
Expert Review of Neurotherapeutics, 2001
Lamotrigine is a newly available antiepileptic drug with a broad spectrum of efficacy and a tolerability profile that is favorable for use in many patients. Problems with rash are related to rate of dose ascension and drug interactions with valproate.
openaire +2 more sources
Lamotrigine is a newly available antiepileptic drug with a broad spectrum of efficacy and a tolerability profile that is favorable for use in many patients. Problems with rash are related to rate of dose ascension and drug interactions with valproate.
openaire +2 more sources
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 1995
Lamotrigine is a novel antiepileptic that, although its mechanism is not completely understood, appears to affect voltage‐activated sodium channels, resulting in inhibition of the presynaptic release of the excitatory neurotransmitter glutamate. It is well absorbed after oral administration. Its route of elimination is hepatic glucuronidation, which is
openaire +2 more sources
Lamotrigine is a novel antiepileptic that, although its mechanism is not completely understood, appears to affect voltage‐activated sodium channels, resulting in inhibition of the presynaptic release of the excitatory neurotransmitter glutamate. It is well absorbed after oral administration. Its route of elimination is hepatic glucuronidation, which is
openaire +2 more sources
Clinical Neuropharmacology, 1994
Summary:Lamotrigine (LTG) is a novel antiepileptic drug (AED) with a spectrum of activity in animal models of epilepsy similar to that of phenytoin and carbam‐azepine. In some models it appears to have a broader spectrum and better tolerability than these agents, however.
openaire +2 more sources
Summary:Lamotrigine (LTG) is a novel antiepileptic drug (AED) with a spectrum of activity in animal models of epilepsy similar to that of phenytoin and carbam‐azepine. In some models it appears to have a broader spectrum and better tolerability than these agents, however.
openaire +2 more sources
Journal of Child Neurology, 1997
The pharmacokinetics of lamotrigine have been studied in single and multiple dose studies in animals, normal volunteers, and patients with epilepsy. Lamotrigine exhibits first-order linear pharmacokinetics. Lamotrigine is well absorbed with bioavailability approaching 100%. The absorption is unaffected by food and there is no first-pass metabolism. The
openaire +2 more sources
The pharmacokinetics of lamotrigine have been studied in single and multiple dose studies in animals, normal volunteers, and patients with epilepsy. Lamotrigine exhibits first-order linear pharmacokinetics. Lamotrigine is well absorbed with bioavailability approaching 100%. The absorption is unaffected by food and there is no first-pass metabolism. The
openaire +2 more sources