Results 41 to 50 of about 17,260 (260)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Socio-demographic impacts on lane-changing response time and distance in work zone with Drivers' Smart Advisory System

Journal of Traffic and Transportation Engineering (English ed. Online), 2015
Lane-changing behavior is an important component of traffic simulation. A lane-changing action is normally confined to a decision-making process of the task, and the action itself is sometimes assumed as an instantaneous event. Besides, the lane-changing
Qing Li, Fengxiang Qiao, Lei Yu
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Lane-changing risk analysis of passenger cars on highways based on the HighD dataset

Shenzhen Daxue xuebao. Ligong ban
To investigate the microscopic lane-changing behavior characteristics and associated risk for passenger cars on highways, we extracted lane-changing trajectories of the subject vehicle and driving data of surrounding vehicles from the HighD dataset.
LIU Tong, YANG Bo, YANG Xueqi, LIU Tangzhi, LIU Xingliang, WU Pan   +5 more
doaj   +1 more source

A Novel Dynamic Lane-Changing Trajectory Planning Model for Automated Vehicles Based on Reinforcement Learning

Journal of Advanced Transportation, 2022
Lane changing behavior has a significant impact on traffic efficiency and may lead to traffic delays or even accidents. It is important to plan a safe and efficient lane-changing trajectory that coordinates with the surrounding environment.
Cenxin Yu, Anning Ni, Jing Luo, Jinghui Wang, Chunqin Zhang, Qinqin Chen, Yifeng Tu   +6 more
doaj   +1 more source

A review on machine learning-based models for lane-changing behavior prediction and recognition

Frontiers in Future Transportation, 2023
A major aspect in the development of advanced driving assistance systems (ADASs) is the research in developing human driving behavior prediction and recognition models.
Ruth David, Dirk Söffker
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Safe and efficient DRL driving policies using fuzzy logic for urban lane changing scenarios

Journal of Intelligent and Connected Vehicles
Lane changing is common in driving. Thus, the possibility of traffic accidents occurring during lane changes is high given the complexity of this process. One of the primary objectives of intelligent driving is to increase a vehicle’s behavior, making it
Ling Han, Xiangyu Ma, Yiren Wang, Lei He, Yipeng Li, Lele Zhang, Qiang Yi   +6 more
doaj   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Research on Mandatory Lane-Changing Behavior in Highway Weaving Sections

Journal of Advanced Transportation, 2020
As the accident-prone sections and bottlenecks, highway weaving sections will become more complicated when it comes to the mixed-traffic environments with connected and automated vehicles (CAVs) and human-driven vehicles (HVs).
Wei Hao, Zhaolei Zhang, Zhibo Gao, Kefu Yi, Li Liu, Jie Wang   +5 more
doaj   +1 more source