Results 51 to 60 of about 17,260 (260)

Influence of Lane-Changing Behavior on Traffic Flow Velocity in Mixed Traffic Environment

Journal of Advanced Transportation, 2022
In mixed traffic with autonomous vehicles, the relationship between speed and lane-changing behavior is an important basis for mixed traffic control. In this study, we use empirical, simulation, and data-driven methods to study the relationship between ...
Han Xie, Qinghua Ren, Zheng Lei
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Modeling Lane-Changing Behavior in Freeway Off-Ramp Areas from the Shanghai Naturalistic Driving Study

Journal of Advanced Transportation, 2018
The objective of this study is to investigate lane-changing characteristics in freeway off-ramp areas using Shanghai Naturalistic Driving Study (SH-NDS) data, considering a four-lane freeway stretch in various traffic conditions.
Lanfang Zhang, Cheng Chen, Jiayan Zhang, Shouen Fang, Jinming You, Jingqiu Guo   +5 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Dynamic Multiobjective Optimization of Lane-Changing Trajectories Based on Reinforcement Learning

Journal of Advanced Transportation
To enhance the rationality of lane-changing decisions and the adaptability of trajectory planning, this study incorporates short-term driving styles to construct a multiobjective optimized lane-changing trajectory planning model based on naturalistic ...
Mengzhu Yang, Jianjun Wang, Jingtao Li
doaj   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Integrating Patient‐Reported Quality Measures in Systemic Lupus Erythematosus: Development of the American College of Rheumatology Implementation Guide

Arthritis Care &Research, EarlyView.
Objective To support high‐quality, patient‐centered care for systemic lupus erythematosus (SLE), the American College of Rheumatology (ACR) developed evidence‐based measures incorporating clinical and patient‐reported outcome measures (PROMs). Using the Consolidated Framework for Implementation Research (CFIR), we conducted semistructured interviews ...
Catherine Nasrallah, Cherish Wilson, Christine Hariz, Christie M. Bartels, Shanthini Kasturi, Wambui Machua, Amy Bennett, Kate Chiseri, Allison Plitman, Starla Hairston Blanks, April Jorge, Patti Katz, Jinoos Yazdany, Shivani Garg   +13 more
wiley   +1 more source

Effect model of urban traffic congestion on driver’s lane-changing behavior

Advances in Mechanical Engineering, 2017
Road traffic congestion has become a normal state and caused many problems in large cities of China, and lane-changing model has attracted increased attention in recent years.
Weiwei Qi, Huiying Wen, Yaping Wu, Lihui Qin   +3 more
doaj   +1 more source

A lane-changing behavioral preferences learning agent with its applications

Computer Science and Information Systems, 2015
Traditional lane-changing (LC) behavioral researches usually focus on the driver?s cognitive performance which includes the driver?s psychological and behavioral habit characteristics, rarely involving the affection of expert driver?s comprehensive behavioral preferences, such as: safety and comfort performance in LC process.
Jian Wang 0022, Baigen Cai, Jiang Liu 0007, Wei ShangGuan   +3 more
openaire   +1 more source

Shape Memory Microneedle to Prevent Risks of Reproductive Hormone Therapy by Switching Sustained to Burst Release Under a Single Transdermal Insertion

Advanced Functional Materials, EarlyView.
A shape‐memory microneedle system enables reproductive hormone therapy through a single transdermal insertion. The X‐shaped device sustains follicle‐stimulating hormone release for three days, and mild heating restores the O shape to trigger burst human chorionic gonadotropin release.
Sungwoo Cho, Hyunjae Kim, Seung Eun Yu, Sangmin Lee, Ji Youn Lee, Mi‐Lan Kang, Kang Suk Lee, Young Sik Choi, Hak‐Joon Sung   +8 more
wiley   +1 more source