Results 41 to 50 of about 5,474,804 (287)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Research and modeling of the lane-changing behavior on the approach

Acta Physica Sinica, 2014
In order to analyze the lane-changing behavior on the upstream of the intersections, based on the cellular automata traffic theory, a comprehensive lane-changing model for the traffic flow near the approach is proposed by combining the improved mandatory lane-changing model and discretionary lane-changing model.
null Wei Li-Ying, null Wang Zhi-Long, null Wu Rong-Hua   +2 more
openaire   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Lane Changing Models: A Short Review

, 2021
In general, drivers tend to change lane to have a convenient journey. Lane changing process give notable impact in traffic flow especially in congested road.
Yunus, Nur Ezzati, Abdul Razak, Siti Fatimah, Siti Fatimah Abdul Razak, Sumendra Yogarayan, Yogarayan, Sumendra, Abdullah, Mohd Fikri Azli, Mohd Fikri Azli Abdullah, Nur Ezzati Yunus   +7 more
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Analysis of the Relationship between Vehicle Behaviors of Changing Lane and Volume of Traffic under Different Operating Ratios of Autonomous Vehicles

Journal of Advanced Transportation, 2022
The lane-changing behavior is one of the important causes in traffic accident in congest traffic, and many behaviors of change lane affect volume of traffic.
Han Xie, Kehong Li, Juanxiu Zhu
doaj   +1 more source

Characteristic Analysis and Decision Model of Lane-Changing Game for Intelligent Connected Vehicles

Applied Sciences, 2023
To study the lane-change interaction characteristics of intelligent connected vehicles (ICVs) and reduce the risk of vehicle lane-changing decisions, a decision model based on the lane-changing game characteristics of the ICV is proposed in this paper ...
Dayi Qu, Shouchen Dai, Aodi Li, Yicheng Chen, Chuanbao Wei   +4 more
doaj   +1 more source

Analysis of Lane-Changing Decision-Making Behavior and Molecular Interaction Potential Modeling for Connected and Automated Vehicles

, 2022
With the technical support of an intelligent networking environment, autonomous driving technology is facing a new stage of development, and the decision-making behavior of autonomous vehicles is changing fundamentally, so it is urgent to explore the ...
Dayi Qu, Tao Wang, Shouchen Dai, Kekun Zhang, Hui Song   +4 more
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source