Results 111 to 120 of about 5,672 (207)

In vivo dynamics of T cells and their interactions with dendritic cells in mouse cutaneous graft-versus-host disease

Blood Advances, 2019
: Graft-versus-host disease (GVHD) is a major cause of morbidity and mortality in allogeneic hematopoietic stem cell transplantation (alloSCT). By static microscopy, cutaneous GVHD lesions contain a mix of T cells and myeloid cells.
Sarah Morin-Zorman, Christian Wysocki, Jieqing Zhu, Hongmei Li, Sylvain Zorman, Catherine Matte-Martone, Edwina Kisanga, Jennifer McNiff, Dhanpat Jain, David Gonzalez, David M. Rothstein, Fadi G. Lakkis, Ann Haberman, Warren D. Shlomchik   +13 more
doaj   +1 more source

T/F viruses have a lowered sensitivity to langerin restriction.

, 2019
U87 cells were transduced to express langerin, or langerin with a SNP (W264R) that abrogates binding via the CRD, and infected with T/F-viruses or NL4.3Bal. Levels of infection were calculated relative to the percentage of infection in the non-transduced
John L. van Hamme (8157393), Neeltje A. Kootstra (8157396), Tanja M. Kaptein (8157390), John C. Kappes (8114477), Persephone Borrow (194557), Angharad E. Fenton-May (8157387), Nina Hertoghs (8157378), Beatrice H. Hahn (8157399), Carla M. S. Ribeiro (8157402), Nienke H. van Teijlingen (8157384), Teunis B. H. Geijtenbeek (8157405), Bernadien M. Nijmeijer (8157381)   +11 more
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Conditional deletion of TGF-βR1 using Langerin-Cre mice results in Langerhans cell deficiency and reduced contact hypersensitivity

, 2011
The critical role of Langerhans cells (LC) in contact hypersensitivity (CHS) was recently questioned in studies using different LC-depletion mouse models.
Martina, C.A.E. (Cerithsa A.), Kel, J.M. (Junda), Kel, Junda, van Roon, MA, Clausen, B.E. (Bjorn), Inge Brouwers-Haspels, Junda M. Kel, Cerithsa A. E. Martina, Björn E. Clausen, Marian A. van Roon, Brouwers - Haspels, Inge, Zahner, Sonja, Brouwers-Haspels, I. (Inge), Roon, M.A. (Marian) van, Martina, CAE, Sonja P. Zahner, Clausen, Björn, Zahner, S.P. (Sonja P.)   +17 more
core   +1 more source

Second generation of Fucose-based DC-SIGN ligands : affinity improvement and specificity versus Langerin [PDF]

, 2011
DC-SIGN and Langerin are two C-type lectins involved in the initial steps of HIV infections: the former acts as a viral attachment factor and facilitates viral invasion of the immune system, the latter has a protective effect.
Elisabetta Moroni, Eric Chabrol, Manuel Andreini, M. Andreini, Franck Fieschi, M. Thepaut, I. Sutkeviciute, Anna Bernardi, DOKNIC, DANIELA, Janxin Duan, E. Moroni, F. Fieschi, Michel Thepaut, Laura Belvisi, L. Belvisi, E. Chabrol, Fabio Doro, J. Rojo, Ieva Sutkeviciute, A. Bernardi, J.J. Reina Martín, J. Duan, F. Doro, Javier Rojo, J. Weiser, Daniela Doknic, Joerg Weiser, José J. Reina   +27 more
core   +1 more source

Selective accumulation of langerhans-type dendritic cells in small airways of patients with COPD

Respiratory Research, 2010
Background Dendritic cells (DC) linking innate and adaptive immune responses are present in human lungs, but the characterization of different subsets and their role in COPD pathogenesis remain to be elucidated.
Vermassen Frank E, Verleden Geert M, van Drunen Cornelis M, Reinartz Susanne M, De Rijck Kim, Demedts Ingel K, Bracke Ken R, Van Pottelberge Geert R, Joos Guy F, Brusselle Guy G   +9 more
doaj   +1 more source

Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells [PDF]

, 2004
Langerhans cells (LCs) constitute a subset of DCs that initiate immune responses in skin. Using leprosy as a model, we investigated whether expression of CD1a and langerin, an LC-specific C-type lectin, imparts a specific functional role to LCs.
Anne E. Burdick, Ochoa, Maria Teresa, John T. Belisle, Blauvelt, Andrew, Steven A. Porcelli, Belisle, John T, Makoto Sugaya, Sieling, Peter A, Patrick J. Brennan, Brennan, Patrick J, Porcelli, Steven A, Robert L. Modlin, Peter A. Sieling, Rea, Thomas H, Hunger, Robert E, Burdick, Anne E, Modlin, Robert L, Maria Teresa Ochoa, Thomas H. Rea, Robert E. Hunger, Sugaya, Makoto, Andrew Blauvelt   +21 more
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Langerin ECD interaction onto heparin.

, 2013
Surface was functionalized with heparin 6 kDa. 100 µL Langerin ECD at 500 nM are injected onto the surface in a Ca2+ containing running buffer. Two modes of surface regenerations are tested, 1: Injection of 30 µL of 50 mM EDTA.
Romain R. Vivès (296307), Antoine Daina (170216), Franck Fieschi (296308), Eric Chabrol (296302), Michel Thepaut (296305), Eric Girard (266610), Emilie Vassal-Stermann (296304), Alessandra Nurisso (296303)   +7 more
core   +1 more source

Cutting edge: Langerin/CD207 receptor on dendritic cells mediates efficient antigen presentation on MHC I and II products in vivo [PDF]

, 2008
The targeted delivery of Ags to dendritic cell (DCs) in vivo greatly improves the efficiency of Ag presentation to T cells and allows an analysis of receptor function.
Suda, Koji, Cheong, Cheolho, Idoyaga, Juliana   +2 more
core  

Langerin(+) Dermal Dendritic Cells Are Critical for CD8(+) T Cell Activation and IgH gamma-1 Class Switching in Response to Gene Gun Vaccines

, 2011
The C-type lectin langerin/CD207 was originally discovered as a specific marker for epidermal Langerhans cells (LC). Recently, additional and distinct subsets of langerin(+) dendritic cells (DC) have been identified in lymph nodes and peripheral tissues ...
Maissen, B., Mehrnaz Mesdaghi, Stoecklinger, A., Angelika Stoecklinger, Bernard Malissen, Josef Thalhamer, Eticha, Tekalign D, Malissen, Bernard, Peter Hammerl, Hammerl, Peter, Mesdaghi, Mehrnaz, Mesdaghi, M., Adrien Kissenpfennig, Eticha, T.D., Stoecklinger, Angelika, Hammerl, P., Tekalign D. Eticha, Thalhamer, Josef, Thalhamer, J., Kissenpfennig, Adrien   +19 more
core   +1 more source

Skin langerin+ dendritic cells transport intradermally injected anti-DEC-205 antibodies but are not essential for subsequent cytotoxic CD8+ T cell responses

, 2012
Incorporation of Ags by dendritic cells (DCs) increases when Ags are targeted to endocytic receptors by mAbs. We have previously demonstrated in the mouse that mAbs against C-type lectins administered intradermally are taken up by epidermal Langerhans ...
Haid, Bernhard, Stoitzner, Patrizia, Tripp, Christoph, Malissen, Bernard, Romani, Nikolaus, Flacher, Vincent, Tripp, Christoph H, Kissenpfennig, Adrien, Idoyaga, Juliana   +8 more
core   +1 more source