Results 91 to 100 of about 8,253 (208)

Ezh2 Controls Skin Tolerance through Distinct Mechanisms in Different Subsets of Skin Dendritic Cells

iScience, 2018
Summary: Ezh2, a well-established epigenetic repressor, can down-regulate leukocyte inflammatory responses, but its role in cutaneous health remains elusive.
Jia Tong Loh, Thomas Jun Feng Lim, Kyoko Ikumi, Takuma Matoba, Baptiste Janela, Merry Gunawan, Tatsuya Toyama, Maegan Bunjamin, Lai Guan Ng, Michael Poidinger, Akimichi Morita, Florent Ginhoux, Sayuri Yamazaki, Kong-Peng Lam, I-hsin Su   +14 more
doaj   +1 more source

Expression of Langerin/CD207 reveals dendritic cell heterogeneity between inbred mouse strains [PDF]

Immunology, 2008
SummaryLangerin/CD207 is expressed by a subset of dendritic cells (DC), the epithelial Langerhans cells. However, langerin is also detected among lymphoid tissue DC. Here, we describe striking differences in langerin‐expressing cells between inbred mouse strains. While langerin+ cells are observed in comparable numbers and with comparable phenotypes in
Flacher, Vincent, Douillard, Patrice, Aït-Yahia, Smina, Stoitzner, Patrizia, Clair-Moninot, Valérie, Romani, Nikolaus, Saeland, Sem   +6 more
openaire   +3 more sources

Systematic Chemoenzymatic Synthesis of O-Sulfated Sialyl Lewis x Antigens. [PDF]

, 2015
O-Sulfated sialyl Lewis x antigens play important roles in nature. However, due to their structural complexity, they are not readily accessible by either chemical or enzymatic synthetic processes.
Chen, Xi, Kenyond, Nicholas J, Li, Yanhong, Louie, Angelique Y, Muthana, Musleh M, Santra, Abhishek, Tasnima, Nova, Yu, Hai, Zeng, Jie   +8 more
core   +1 more source

CD207‐Positive Dendritic Cells Promote Emphysema Through CD8+ T Cell Pathway in Chronic Obstructive Pulmonary Disease

Advanced Science, Volume 13, Issue 16, 18 March 2026.
CD207+ dendritic cells (DCs) drive emphysema by promoting CD8⁺ T cell cytotoxicity via Birbeck granule‐dependent MHC‐I antigen presentation. This DC subset is expanded by cigarette smoke‐induced oxidative stress, which triggers granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) release from airway epithelium.
Shurui Xuan, Yunhui Wu, Feng Liu, Heng Fu, Yaqi Meng, Yingwei Ou, Xijing Yuan, Ian M. Adcock, Man Jia, Xiaoning Zeng, Xin Yao   +10 more
wiley   +1 more source

Langerin+ DCs regulate innate IL-17 production in the oral mucosa during Candida albicans-mediated infection.

PLoS Pathogens, 2018
The opportunistic fungal pathogen Candida albicans frequently causes diseases such as oropharyngeal candidiasis (OPC) in immunocompromised individuals. Although it is well appreciated that the cytokine IL-17 is crucial for protective immunity against OPC,
Florian Sparber, Tamas Dolowschiak, Sarah Mertens, Laura Lauener, Björn E Clausen, Nicole Joller, Patrizia Stoitzner, Roxane Tussiwand, Salomé LeibundGut-Landmann   +8 more
doaj   +1 more source

Langerin+CD8+ Dendritic Cells in the Splenic Marginal Zone: Not So Marginal After All

Frontiers in Immunology, 2019
Dendritic cells (DC) fulfill an essential sentinel function within the immune system, acting at the interface of innate and adaptive immunity. The DC family, both in mouse and man, shows high functional heterogeneity in order to orchestrate immune ...
Ronald A. Backer, Nathalie Diener, Björn E. Clausen   +2 more
doaj   +1 more source

Duality of β-glucan microparticles: antigen carrier and immunostimulants [PDF]

, 2016
Designing efficient recombinant mucosal vaccines against enteric diseases is still a major challenge. Mucosal delivery of recombinant vaccines requires encapsulation in potent immunostimulatory particles to induce an efficient immune response. This paper
Baert, Kim, Cox, Eric, De Geest, Bruno, De Greve, Henri, Devriendt, Bert   +4 more
core   +2 more sources

Emergence of Staphylococcus aureus Resistance to Antimicrobial Peptides Nisin, NZ2114 and Bacitracin Involves Multiple Phenotypic Changes

Animal Research and One Health, Volume 4, Issue 1, Page 82-93, February 2026.
The AMP‐induced mutant Staphylococcus aureus strain nzR showed increased resistance, five gene mutations, and decreased surface anion levels. AMPs affect the NDH‐2 protein encoded by ndh gene inhibiting the growth of S. aureus. The deletion of the ndh gene promotes the development of AMPs resistance.
Lingyu Xiao, Xingyuan Ma, Ping Tian, Lianbin Li, Zafir Muhammad, Xiaokun Wang, Xuemei Xue, Jinhe Xiao, Liangjun Zheng, F. A. El‐Gohary, Xin Zhao, Junning Pu, Huping Xue   +12 more
wiley   +1 more source

Exploiting the role of endogenous lymphoid-resident dendritic cells in the priming of NKT cells and CD8+ T cells to dendritic cell-based vaccines.

PLoS ONE, 2011
Transfer of antigen between antigen-presenting cells (APCs) is potentially a physiologically relevant mechanism to spread antigen to cells with specialized stimulatory functions.
Troels R Petersen, Dianne Sika-Paotonu, Deborah A Knight, Helen M A Simkins, Ian F Hermans   +4 more
doaj   +1 more source

Up-regulation of the chemokine CCL21 in the skin of subjects exposed to irritants [PDF]

, 2004
Background Expression of murine CCL21 by dermal lymphatic endothelial cells (LEC) has been demonstrated to be one of the most important steps in Langerhans cell emigration from skin.
Yanina Eberhard, Susana Ortiz, Alejandro Ruiz Lascano, Raquel Kuznitzky, Horacio Serra   +4 more
core   +2 more sources