Results 81 to 90 of about 5,672 (207)

Epidemiology of Canine Cutaneous Histiocytoma: Insights From Age and Topographic Clustering

Veterinary Dermatology, Volume 37, Issue 5, Page 780-787, October 2026.
Background: Canine cutaneous histiocytoma (CCH) is a benign Langerhans‐cell tumour that often regresses spontaneously via inflammation. Objectives: To estimate incidence and characterise age and breed–anatomical‐site patterns using two complementary clustering analyses.
C. De Moura, K. Pinello, J. Catarino, J. Niza‐Ribeiro, J. Santos, P. Faísca   +5 more
wiley   +1 more source

TNF-alpha induces the generation of Langerin/(CD207)+ immature Langerhans-type dendritic cells from both CD14-CD1a and CD14+CD1a- precursors derived from CD34+ cord blood cells.

, 2003
CD34+ cell-derived hematopoietic precursors amplified with FLT3-ligand, thrombopoietin and stem cell factor became, after a 6-day induction with GM-CSF, IL-4 and TGF-beta1, HLA-DR+, CD1a+, CD83-, CD86-, CD80- cells. A fraction of them expressed Langerin,
Kindler V, Soulas C, Saeland S, Hauser C, Arrighi JF, Chapuis B, Zubler RH   +6 more
core   +1 more source

Ezh2 Controls Skin Tolerance through Distinct Mechanisms in Different Subsets of Skin Dendritic Cells

iScience, 2018
Summary: Ezh2, a well-established epigenetic repressor, can down-regulate leukocyte inflammatory responses, but its role in cutaneous health remains elusive.
Jia Tong Loh, Thomas Jun Feng Lim, Kyoko Ikumi, Takuma Matoba, Baptiste Janela, Merry Gunawan, Tatsuya Toyama, Maegan Bunjamin, Lai Guan Ng, Michael Poidinger, Akimichi Morita, Florent Ginhoux, Sayuri Yamazaki, Kong-Peng Lam, I-hsin Su   +14 more
doaj   +1 more source

Langerhans Cell Histiocytosis in Adults: A Canadian Multicenter Case Series

Hematological Oncology, Volume 44, Issue 5, September 2026.
ABSTRACT Langerhans cell histiocytosis (LCH) is a rare clonal myeloid neoplasm. Canadian data on clinical characteristics, molecular profile, and treatment outcomes is limited. This study aims to report the initial experience of a Canadian rare diseases program, reflecting “real‐world” diagnostic pathways, referral patterns, and treatment heterogeneity
Stephanie Quon, Yaswanta Gummadi, Ibrahim Elsharawi, Jessica Dobson, Mariam Goubran, Ryan J. Stubbins, Eli L. Diamond, Luke Y. C. Chen   +7 more
wiley   +1 more source

A large multilobulated cutaneous nodule in infancy

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Hannah Wahida, Andy Yan, Stephan Forchhammer   +2 more
wiley   +1 more source

Histiocytosis development and clinical variation through the lens of genomics

The Journal of Pathology, Volume 270, Issue 1, Page 23-39, September 2026.
Abstract Histiocytic neoplasms are rare haematologic diseases characterised by clonal expansions of cells with a monocyte, macrophage or dendritic cell phenotype. Their clinical manifestations are diverse, ranging from indolent lesions to aggressive systemic disease.
Paul G Kemps, Astrid GS van Halteren, Tom van Wezel, Pancras CW Hogendoorn   +3 more
wiley   +1 more source

Caveolin-1 mediated uptake via langerin restricts HIV-1 infection in human Langerhans cells

, 2014
Human Langerhans cells (LCs) reside in foreskin and vaginal mucosa and are the first immune cells to interact with HIV-1 during sexual transmission.
Everts, V.E., Esther M Zijlstra-Willems, Geijtenbeek, T.B.H., Linda M van den Berg, Tigchelaar, Wikky, Everts, Vincent, Geijtenbeek, Teunis B. H., van den Berg, Linda M., Ribeiro, C.M.S., Fluitsma, D.M., de Witte, L, Zijlstra-Willems, E.M., Zijlstra-Willems, Esther M., Wikky Tigchelaar, Ribeiro, Carla M. S., Fluitsma, Donna, van den Berg, L.M., Vincent Everts, Donna Fluitsma, de Witte, Lot, Teunis B H Geijtenbeek, Carla M S Ribeiro, Lot de Witte, Tigchelaar, W.   +23 more
core   +1 more source

Langerin+ DCs regulate innate IL-17 production in the oral mucosa during Candida albicans-mediated infection.

PLoS Pathogens, 2018
The opportunistic fungal pathogen Candida albicans frequently causes diseases such as oropharyngeal candidiasis (OPC) in immunocompromised individuals. Although it is well appreciated that the cytokine IL-17 is crucial for protective immunity against OPC,
Florian Sparber, Tamas Dolowschiak, Sarah Mertens, Laura Lauener, Björn E Clausen, Nicole Joller, Patrizia Stoitzner, Roxane Tussiwand, Salomé LeibundGut-Landmann   +8 more
doaj   +1 more source

Pyodermatitis-Pyostomatitis Vegetans: The Role of Langerin Deficiency in Disease Pathogenesis. [PDF]

J Clin Med
Background/Objectives: Pyodermatitis–pyostomatitis vegetans (PPV) is a rare, chronic inflammatory mucocutaneous disorder. However, the etiology of PPV remains controversial. Methods: A review of online PPV case studies from PubMed, Wanfang database, Web of Science, and books has been performed.
Pan D, Wang J, Cai L, Huang M, Han Q, Zheng Z, Zeng X, Chen Q, Ai R, Zhou Y.   +9 more
europepmc   +3 more sources

Perineurioma‐like EMA‐positive calvarial neoplasms: clinicopathological study of eight cases

Histopathology, Volume 89, Issue 3, Page 544-553, September 2026.
Perineurioma‐like, EMA‐positive calvarial neoplasms (PLECN) are a rare group of intraosseous spindle cell tumours that demonstrate overlapping morphologic features of perineurioma and fibroblastic meningioma. These lesions tend to behave indolently but show a propensity for progressive growth.
Raheel Rizwan, Yingting Mok, Josephine K Dermawan, Alexandra Isaacson, Veronica Ulici, Scott E Kilpatrick, John D Reith, Gabrielle Yeaney, Hakan Ilaslan, Karen J Fritchie   +9 more
wiley   +1 more source