Results 61 to 70 of about 5,193 (199)

Langerin, the “Catcher in the Rye”: An important receptor for pathogens on Langerhans cells [PDF]

European Journal of Immunology, 2011
AbstractLangerhans cells (LCs) are a distinct subset of DCs that resides in the epidermis and other epithelia. They are potent antigen‐presenting cells and strong inducers of T‐cell responses. Like other DC types, LCs express C‐type lectins that serve as antigen/pathogen uptake receptors, with Langerin/CD207 being the characteristic LC C‐type lectin ...
Patrizia, Stoitzner, Nikolaus, Romani
openaire   +2 more sources

Impaired Differentiation of Langerhans Cells in the Murine Oral Epithelium Adjacent to Titanium Dental Implants

Frontiers in Immunology, 2018
Peri-implantitis is a destructive inflammatory process affecting tissues surrounding dental implants and it is considered a new global health concern.
Oded Heyman, Noam Koren, Gabriel Mizraji, Gabriel Mizraji, Tal Capucha, Sharon Wald, Maria Nassar, Yaara Tabib, Lior Shapira, Avi-Hai Hovav, Asaf Wilensky   +10 more
doaj   +1 more source

Activin A induces Langerhans cell differentiation in vitro and in human skin explants. [PDF]

PLoS ONE, 2008
Langerhans cells (LC) represent a well characterized subset of dendritic cells located in the epidermis of skin and mucosae. In vivo, they originate from resident and blood-borne precursors in the presence of keratinocyte-derived TGFbeta.
Tiziana Musso, Sara Scutera, William Vermi, Roberta Daniele, Michele Fornaro, Carlotta Castagnoli, Daniela Alotto, Maria Ravanini, Irene Cambieri, Laura Salogni, Angela Rita Elia, Mirella Giovarelli, Fabio Facchetti, Giampiero Girolomoni, Silvano Sozzani   +14 more
doaj   +1 more source

Genetic analysis of primary lung interdigitating dendritic cell sarcomas

The Journal of Pathology, EarlyView.
Abstract Interdigitating dendritic cell sarcomas (IDCSs) are rare tumors that commonly arise in the hematopoietic system and rarely outside. The genetic drivers of IDCS carcinogenesis are unknown; therefore, therapeutic options are limited. We investigated somatic gene mutations and copy‐number alterations (CNAs) in nine IDCSs arising in the lung by ...
Mikhail S Ermakov, Juliana Faria Filipe, Sylvia Eidenhammer, German Ott, Iris Halbwedl, Karl Kashofer, Helmut Popper   +6 more
wiley   +1 more source

Histiocytosis development and clinical variation through the lens of genomics

The Journal of Pathology, EarlyView.
Abstract Histiocytic neoplasms are rare haematologic diseases characterised by clonal expansions of cells with a monocyte, macrophage or dendritic cell phenotype. Their clinical manifestations are diverse, ranging from indolent lesions to aggressive systemic disease.
Paul G Kemps, Astrid GS van Halteren, Tom van Wezel, Pancras CW Hogendoorn   +3 more
wiley   +1 more source

Identification of the Allosteric Binding Site for Thiazolopyrimidine on the C-Type Lectin Langerin

ACS Chemical Biology, 2022
Langerin is a mammalian C-type lectin expressed on Langerhans cells in the skin. As an innate immune cell receptor, Langerin is involved in coordinating innate and adaptive immune responses against various incoming threats. We have previously reported a series of thiazolopyrimidines as murine Langerin ligands. Prompted by the observation that its human
Hengxi Zhang, Carlos P. Modenutti, N. Y. Phani Kumar, Maxime Denis, Iris A. Bermejo, Jonathan Lefèbre, Kateryna Che, Dongyoon Kim, Marten Kagelmacher, Dennis Kurzbach, Marc Nazaré, Christoph Rademacher   +11 more
openaire   +4 more sources

Heparin decasaccharide in complex with Langerin.

, 2013
Predicted binding mode of the heparin decasaccharide (displayed in space fill -A- and capped stick -B-) in complex with Langerin. Langerin is represented with its Connolly surface color-coded according to the electrostatic potential (from blue for ...
Romain R. Vivès (296307), Antoine Daina (170216), Franck Fieschi (296308), Eric Chabrol (296302), Michel Thepaut (296305), Eric Girard (266610), Emilie Vassal-Stermann (296304), Alessandra Nurisso (296303)   +7 more
core   +1 more source

Molecular Interactions of β-(1→3)-Glucans with Their Receptors

Molecules, 2015
β-(1→3)-Glucans can be found as structural polysaccharides in cereals, in algae or as exo-polysaccharides secreted on the surfaces of mushrooms or fungi.
Laurent Legentil, Franck Paris, Caroline Ballet, Sophie Trouvelot, Xavier Daire, Vaclav Vetvicka, Vincent Ferrières   +6 more
doaj   +1 more source

A Rare Case of Cutaneous Crystal‐Storing Histiocytosis With Kappa Light Chain Restriction and Unusual BCL6 Expression

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Crystal‐storing histiocytosis (CSH) is a rare histopathologic phenomenon characterized by the accumulation of crystalline material within histiocytes, most often associated with lymphoplasmacytic or plasma cell neoplasms. Cutaneous involvement is uncommon and may present diagnostic challenges.
Liangli Wang, Jonathan L. Curry, Julia Dai, Daniel H. Wang, Paolo Strati, Melody R. Becnel, Leomar Y. Ballester, Carlos A. Torres‐Cabala, Phyu P. Aung   +8 more
wiley   +1 more source

Human anogenital monocyte-derived dendritic cells and langerin+cDC2 are major HIV target cells

Nature Communications, 2021
Epithelial tissue mononuclear phagocytes (MNP) can transmit HIV to CD4 T cells, but less is known about sub-epithelial cells. Here, the authors describe MNPs in human anogenital and colorectal tissues and find that CD14+CD1c+ monocyte-derived dendritic ...
Jake W. Rhodes, Rachel A. Botting, Kirstie M. Bertram, Erica E. Vine, Hafsa Rana, Heeva Baharlou, Peter Vegh, Thomas R. O’Neil, Anneliese S. Ashhurst, James Fletcher, Grant P. Parnell, J. Dinny Graham, Najla Nasr, Jake J. K. Lim, Laith Barnouti, Peter Haertsch, Martijn P. Gosselink, Angelina Di Re, Faizur Reza, Grahame Ctercteko, Gregory J. Jenkins, Andrew J. Brooks, Ellis Patrick, Scott N. Byrne, Eric Hunter, Muzlifah A. Haniffa, Anthony L. Cunningham, Andrew N. Harman   +27 more
doaj   +1 more source