Results 61 to 70 of about 5,672 (207)

Decoding host–microbial dynamics in peri‐implantitis: Ecosystem‐specific experimental models

Periodontology 2000, EarlyView.
Abstract Background Peri‐implantitis is an inflammatory disease arising within a unique host–microbial–biomaterial ecosystem. Unlike periodontitis, peri‐implant tissues lack a periodontal ligament and epithelial junction integrity and interface with metal oxides on titanium surfaces.
Georgios A. Kotsakis, Davi Araújo, Asaf Wilensky, Juliana Girón Bastidas, Stella Alimperti, Flavia Pirih   +5 more
wiley   +1 more source

GPs localize within Langerin⁺ SED DCs.

, 2014
APC-labeled GPs (blue) were administered to (Panel A) BALB/c or (Panel B) Langerin E-GFP-DTR transgenic mice by gavage, as described in Materials and Methods.
Gary R. Ostroff (499542), Magdia De Jesus (535929), Nicholas J. Mantis (125042), Stuart M. Levitz (59237), Toni R. Bartling (535930)   +4 more
core   +1 more source

Coexpression of CD1a, langerin and Birbeck's granules in Langerhans cell histiocytoses (LCH) in children: ultrastructural and immunocytochemical studies.

Folia Histochemica et Cytobiologica, 2007
Langerhans cell histiocytoses (LCH) represent rare diseases of unclear etiology and pathogenesis. Most of the cases include children, 1 to 15 years of age, and various organs are involved (bones, skin, liver, lymph nodes, bone marrow and other).
Marzena Podhorska-Okołów, Michał Jeleń, Jadwiga Wecławek, Malgorzata Dumańska, Barbara Dolilńska-Krajewska, Piotr Dziegiel, Ewa Jagoda, Magdalena Fic, Maciej Zabel   +8 more
doaj   +1 more source

Identification of the Allosteric Binding Site for Thiazolopyrimidine on the C-Type Lectin Langerin

ACS Chemical Biology, 2022
Langerin is a mammalian C-type lectin expressed on Langerhans cells in the skin. As an innate immune cell receptor, Langerin is involved in coordinating innate and adaptive immune responses against various incoming threats. We have previously reported a series of thiazolopyrimidines as murine Langerin ligands. Prompted by the observation that its human
Zhang, Hengxi, Modenutti, Carlos, Nekkanti, Yelha Phani Kumar, Denis, Maxime, Bermejo, Iris A., Lefèbre, Jonathan, Che, Kateryna, Kim, Dongyoon, Kagelmacher, Marten, Kurzbach, Dennis, Nazaré, Marc, Rademacher, Christoph, 0000-0001-8864-4852, 0000-0001-6455-2136, 0000-0002-1602-2330, 0000-0001-7082-7239   +15 more
openaire   +5 more sources

The dermis contains langerin+ dendritic cells that develop and function independently of epidermal Langerhans cells. [PDF]

, 2007
International audienceLangerhans cells (LCs) constitute a subset of dendritic cells (DCs) that express the lectin langerin and that reside in their immature state in epidermis.
de Bovis, Béatrice, Lionel Franz Poulin, Poulin, Lionel Franz, Adrien Kissenpfennig, Béatrice de Bovis, Bernard Malissen, Malissen, Bernard, Sandrine Henri, Elisabeth Devilard, Henri, Sandrine, Devilard, Elisabeth, Kissenpfennig, Adrien   +11 more
core   +1 more source

Morphological Alterations and Increased S100B Expression in Epidermal Langerhans Cells Detected in Skin from Patients with Progressive Vitiligo

Life, 2021
The role of Langerhans cells (LCs) in vitiligo pathogenesis remains unclear, with published studies reporting contradictory results regarding the quantity of LCs and no data on the features of LCs in vitiligo.
Fei Yang, Lingli Yang, Lanting Teng, Huimin Zhang, Ichiro Katayama   +4 more
doaj   +1 more source

Infantile Central Nervous System Juvenile Xanthogranuloma With Somatic CSF1R Mutation Responsive to Imatinib Monotherapy

Pediatric Blood &Cancer, Volume 73, Issue 10, October 2026.
ABSTRACT Juvenile xanthogranuloma (JXG) of the central nervous system (CNS) is a rare non‐Langerhans cell histiocytosis. CSF1R mutations have been reported for peripheral JXG, but not in CNS JXG. A 3‐month‐old male presented with fever, lymphadenopathy, and macrocephaly with bulging fontanelles.
Sima Vazquez, Kayla Etienne, Long Di, Valerie Martinez‐Torres, Andrew Rosenberg, Sakir H. Gultekin, Aditi Dhir, Bradley Gampel, Heather J. McCrea   +8 more
wiley   +1 more source

Production of monoclonal antibodies that recognize the extracellular domain of mouse Langerin/CD207 [PDF]

Journal of Immunological Methods, 2007
Langerin CD207 is a type II transmembrane protein. It is responsible for the formation of Birbeck granules, which are intracellular organelles within Langerhans cells, the dendritic cells of stratified squamous epithelia like the epidermis. Because current anti-CD207 antibodies have limitations, we prepared new monoclonals by immunizing rats with the ...
Cheong, Cheolho, Idoyaga, Juliana, Do, Yoonkyung, Pack, Maggi, Park, Sung Ho, Lee, Haekyung, Kang, Young-Sun, Choi, Jae-Hoon, Kim, Jae Y., Bonito, Anthony, Inaba, Kayo, Yamazaki, Sayuri, Steinman, Ralph M., Park, Chae Gyu   +13 more
openaire   +3 more sources

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, Volume 13, Issue 58, 19 October 2026.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

Langerin (CD207) represents a novel interferon-stimulated gene in Langerhans cells [PDF]

Cellular & Molecular Immunology, 2019
Interferons (IFNs) are “warning signal” cytokines released upon pathogen sensing. IFNs control the expression of interferon-stimulated genes (ISGs), which are often crucial to restrict viral infections and establish a cellular antiviral state.1,2 Langerin (CD207), a well-known surface receptor on Langerhans cells (LC), belongs to the C-type lectin ...
Ghizlane Maarifi, Magdalena A. Czubala, Justine Lagisquet, Matthew O. Ivory, Kyra Fuchs, Laure Papin, James C. Birchall, Sébastien Nisole, Vincent Piguet, Fabien P. Blanchet   +9 more
openaire   +2 more sources