, 2022 Cutaneous dendritic cells (DCs) have been implicated in the pathogenesis of atopic dermatitis (AD). However, the specific role of different subsets of DCs has not been well defined.
Wei Li (7081) +9 more
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Depletion of langerin+ cells enhances cutaneous wound healing [PDF]
Immunology, 2020 SummaryLangerin is a C‐type lectin receptor that is expressed on Langerhans cells and langerin‐positive dermal dendritic cells in the skin. Little is known about the function of langerin+ cells in wound healing. In this study, the effects of ablation of langerin+ cells on healing of a full‐thickness excision wound were investigated using the langerin ...
Aarthi Rajesh +6 more
openaire +2 more sources
A population of Langerin-positive dendritic cells in murine Peyer's patches involved in sampling β-glucan microparticles. [PDF]
PLoS ONE, 2014 Glucan particles (GPs) are 2-4 μm hollow, porous shells composed of 1,3-β-D-glucan that have been effectively used for oral targeted-delivery of a wide range of payloads, including small molecules, siRNA, DNA, and protein antigens.
Magdia De Jesus +4 more
doaj +1 more source
A Liposomal Platform for Delivery of a Protein Antigen to Langerin-Expressing Cells [PDF]
Biochemistry, 2019 The skin is an attractive site for vaccination and harbors a dense network of Langerhans cells that are the prime target for antigen delivery approaches in the epidermis. While specific targeting of Langerhans cells has been shown to elicit the necessary T-cell response using antibody-based delivery approaches, the targeted administration of ...
Schulze, Jessica +5 more
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Polymorphisms in Human Langerin Affect Stability and Sugar Binding Activity [PDF]
Journal of Biological Chemistry, 2006 Langerhans cells are specialized skin dendritic cells that take up and degrade antigens for presentation to the immune system. Langerin, a cell surface C-type lectin of Langerhans cells, can be internalized and accumulates in Birbeck granules, subdomains of the endosomal recycling compartment that are specific to Langerhans cells.
Eliot M, Ward +3 more
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Batf3-dependent CD11b(low/-) peripheral dendritic cells are GM-CSF-independent and are not required for Th cell priming after subcutaneous immunization. [PDF]
PLoS ONE, 2011 Dendritic cells (DCs) subsets differ in precursor cell of origin, functional properties, requirements for growth factors, and dependence on transcription factors.
Brian T Edelson +9 more
doaj +1 more source
Hepatic Langerhans cell histiocytosis: Report of a rare case
Human Pathology Reports, 2023 Langerhans cell histiocytosis (LCH) is a rare neoplastic disease characterized by abnormal proliferation of Langerhans cells infiltrating various organs, resulting in organ dysfunction.
Renling Yao, Jun Chen, Jie Li
doaj +1 more source
The Essential Role of anxA2 in Langerhans Cell Birbeck Granules Formation
Cells, 2020 Langerhans cells (LC) are the resident antigen presenting cells of the mucosal epithelium and play an essential role in initiating immune responses.
Shantae M. Thornton +7 more
doaj +1 more source
Targeting human langerin promotes HIV-1 specific humoral immune responses.
PLoS Pathogens, 2021 The main avenue for the development of an HIV-1 vaccine remains the induction of protective antibodies. A rationale approach is to target antigen to specific receptors on dendritic cells (DC) via fused monoclonal antibodies (mAb).
Jérôme Kervevan +22 more
doaj +1 more source
Comparison of heparin and gp120 binding mode to Langerin.
, 2013 A) Overlay of sensorgram showing Langerin CRD interaction onto gp120YU2 functionalized surface in Ca2+ buffer. Langerin CRD concentration range is from 400 µM to 12,5 µM with 2 times serial dilution.
Romain R. Vivès (296307) +7 more
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