Results 31 to 40 of about 5,193 (199)

Birbeck granule-like "organized smooth endoplasmic reticulum" resulting from the expression of a cytoplasmic YFP-tagged langerin. [PDF]

PLoS ONE, 2013
Langerin is required for the biogenesis of Birbeck granules (BGs), the characteristic organelles of Langerhans cells. We previously used a Langerin-YFP fusion protein having a C-terminal luminal YFP tag to dynamically decipher the molecular and cellular ...
Cédric Lenormand, Coralie Spiegelhalter, Bertrand Cinquin, Sabine Bardin, Huguette Bausinger, Catherine Angénieux, Anita Eckly, Fabienne Proamer, David Wall, Ben Lich, Sylvie Tourne, Daniel Hanau, Yannick Schwab, Jean Salamero, Henri de la Salle   +14 more
doaj   +1 more source

Indeterminate dendritic cell tumor (IDCT) [PDF]

Vestnik Dermatologii i Venerologii, 2023
Indeterminate dendritic cell tumor (IDCT) is rare histiocytic tumor characterized by the proliferation of indeterminate dendritic cells. It is more often diagnosed in middle-aged people, in approximately equal proportions in men and women.
Evgenia V. Okladnikova, Vladimir M. Merk, Yuriy А. Krivopalov, Vladimir А. Khorzhevskii, Tatiana G. Ruksha   +4 more
doaj   +1 more source

Cryo-electron tomography of Birbeck granules reveals the molecular mechanism of langerin lattice formation

eLife, 2022
Langerhans cells are specialized antigen-presenting cells localized within the epidermis and mucosal epithelium. Upon contact with Langerhans cells, pathogens are captured by the C-type lectin langerin and internalized into a structurally unique vesicle ...
Toshiyuki Oda, Haruaki Yanagisawa, Hideyuki Shinmori, Youichi Ogawa, Tatsuyoshi Kawamura   +4 more
doaj   +1 more source

CD11b+ migratory dendritic cells mediate CD8 T cell cross-priming and cutaneous imprinting after topical immunization. [PDF]

PLoS ONE, 2014
Topical antigen application is a focus of current vaccine research. This immunization route mimics natural antigen exposure across a barrier tissue and generates T cells imprinted for skin-selective homing.
Suzanne T Nizza, James J Campbell
doaj   +1 more source

Expansion of Phenotypically Altered Dendritic Cell Populations in the Small Airways and Alveolar Parenchyma in Patients with Chronic Obstructive Pulmonary Disease

Journal of Innate Immunity, 2022
Contrasting the antigen-presenting dendritic cells (DCs) in the conducting airways, the alveolar DC populations in human lungs have remained poorly investigated. Consequently, little is known about how alveolar DCs are altered in diseases such as chronic
Michiko Mori, Carl-Magnus Clausson, Caroline Sanden, Jimmie Jönsson, Cecilia K. Andersson, Premkumar Siddhuraj, Medya Shikhagaie, Karolina Åkesson, Anders Bergqvist, Claes-Göran Löfdahl, Jonas S. Erjefält   +10 more
doaj   +1 more source

Usutu virus escapes langerin-induced restriction to productively infect human Langerhans cells, unlike West Nile virus

Emerging Microbes and Infections, 2022
Usutu virus (USUV) and West Nile virus (WNV) are phylogenetically close emerging arboviruses transmitted by mosquitoes, and constitute a global public health threat.
Marie-France Martin, Ghizlane Maarifi, Hervé Abiven, Marine Seffals, Nicolas Mouchet, Cécile Beck, Charles Bodet, Nicolas Lévèque, Nathalie J. Arhel, Fabien P. Blanchet, Yannick Simonin, Sébastien Nisole   +11 more
doaj   +1 more source

Adult-onset of Langerhans cell histiocytosis: a clinical case

Alʹmanah Kliničeskoj Mediciny, 2021
Langerhans cell histiocytosis is mainly diagnosed in children, and its manifestation in adult age is quite uncommon. Skin rashes may be non-specific and mimic a number of dermatoses.
Olga V. Chernysheva, Olga V. Dorokhina, Albina N. Khlebnikova, Elena V. Selezneva   +3 more
doaj   +1 more source

Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity [PDF]

, 2005
Langerhans cells (LC) form a unique subset of dendritic cells ( DC) in the epidermis but so far their in vivo functions in skin immunity and tolerance could not be determined, in particular in relation to dermal DC ( dDC).
Clausen, B.E., Inaba, K, Jung, S, Erwin van Rijn, van Rijn, E., Ralph M. Steinman, Clausen, Björn E., Inaba, K., Jung, S., van Rijn, Erwin, Steffen Jung, Clausen, BE, Kapsenberg, Martien L., Kayo Inaba, Inaba, Kayo, van Rijn, E, Bennett, CL, Kapsenberg, ML, Kapsenberg, M.L., Björn E. Clausen, Martien L. Kapsenberg, Jung, Steffen, Steinman, RM, Bennett, C., Steinman, R.M., Bennett, Clare L., Steinman, Ralph M., Clare L. Bennett   +27 more
core   +1 more source

Molecular mechanism of the pH-dependent calcium affinity in langerin [PDF]

, 2020
Abstract The C-type lectin receptor langerin plays a vital role in the mammalian defense against invading pathogens. Its function hinges on the affinity to its co-factor Ca 2+ which in turn is regulated by the pH.
Joswig, Jan-O., Anders, Jennifer, Zhang, Hengxi, Rademacher, Christoph, Keller, Bettina G.   +4 more
openaire   +1 more source

Lipo-Based Vaccines as an Approach to Target Dendritic Cells for Induction of T- and iNKT Cell Responses

Frontiers in Immunology, 2020
In this study we developed a liposome-based vaccine containing palmitoylated synthetic long peptides (SLP) and alpha galactosylceramide (αGC) to specifically target dendritic cells (DC) for activation of both innate (invariant natural killer T-cells ...
Dorian A. Stolk, Aram de Haas, Jana Vree, Jana Vree, Sanne Duinkerken, Joyce Lübbers, Rieneke van de Ven, Rieneke van de Ven, Martino Ambrosini, Hakan Kalay, Sven Bruijns, Hans J. van der Vliet, Hans J. van der Vliet, Tanja D. de Gruijl, Yvette van Kooyk   +14 more
doaj   +1 more source