Results 31 to 40 of about 8,253 (208)

Lipo-Based Vaccines as an Approach to Target Dendritic Cells for Induction of T- and iNKT Cell Responses

Frontiers in Immunology, 2020
In this study we developed a liposome-based vaccine containing palmitoylated synthetic long peptides (SLP) and alpha galactosylceramide (αGC) to specifically target dendritic cells (DC) for activation of both innate (invariant natural killer T-cells ...
Dorian A. Stolk, Aram de Haas, Jana Vree, Jana Vree, Sanne Duinkerken, Joyce Lübbers, Rieneke van de Ven, Rieneke van de Ven, Martino Ambrosini, Hakan Kalay, Sven Bruijns, Hans J. van der Vliet, Hans J. van der Vliet, Tanja D. de Gruijl, Yvette van Kooyk   +14 more
doaj   +1 more source

Polymorphisms in Human Langerin Affect Stability and Sugar Binding Activity [PDF]

Journal of Biological Chemistry, 2006
Langerhans cells are specialized skin dendritic cells that take up and degrade antigens for presentation to the immune system. Langerin, a cell surface C-type lectin of Langerhans cells, can be internalized and accumulates in Birbeck granules, subdomains of the endosomal recycling compartment that are specific to Langerhans cells.
Eliot M, Ward, Nicola S, Stambach, Kurt, Drickamer, Maureen E, Taylor   +3 more
openaire   +2 more sources

Rational Design of a DNA‐Scaffolded High‐Affinity Binder for Langerin [PDF]

Angewandte Chemie International Edition, 2020
AbstractBinders of langerin could target vaccines to Langerhans cells for improved therapeutic effect. Since langerin has low affinity for monovalent glycan ligands, highly multivalent presentation has previously been key for targeting. Aiming to reduce the amount of ligand required, we rationally designed molecularly defined high‐affinity binders ...
Bachem, Gunnar, Wamhoff, Eike-Christian, Silberreis, Kim, Kim, Dongyoon, Baukmann, Hannes, Fuchsberger, Felix F., Dernedde, Jens, Rademacher, Christoph, Seitz, Oliver, Fuchsberger, Felix   +9 more
openaire   +3 more sources

Effect of ultrasound treatment of the skin on activation of Langerhans cells and antibody production in rodents

Journal of Advanced Pharmaceutical Technology & Research, 2023
In this study, we investigated whether stimulating the skin with ultrasound (US) could activate Langerhans cells (LCs) – antigen-presenting cells in the epidermis and stimulate antibody production following the subcutaneous and intradermal injection of ...
Satoko Enjo, Yutaro Hazama, Soichiro Kimura, Yasunori Morimoto, Hideo Ueda   +4 more
doaj   +1 more source

Flt3L-dependence helps define an uncharacterized subset of murine cutaneous dendritic cells [PDF]

, 2014
Skin-derived dendritic cells (DC) are potent antigen presenting cells with critical roles in both adaptive immunity and tolerance to self. Skin DC carry antigens and constitutively migrate to the skin draining lymph nodes (LN).
Anandasabapathy, Niroshana, Cheong, Cheolho, Dobrin, Joseph, Feder, Rachel, Matos, Ines, Mollah, Shamim, Steinman, Ralph M., Tse, Sze-Wah   +7 more
core   +1 more source

Mafb lineage tracing to distinguish macrophages from other immune lineages reveals dual identity of Langerhans cells [PDF]

, 2016
Current systems for conditional gene deletion within mouse macrophage lineages are limited by ectopic activity or low efficiency. In this study, we generated a Mafb-driven Cre strain to determine whether any dendritic cells (DCs) identified by Zbtb46-GFP
Abram, Anguille, Artner, Artyomov, Bain, Bakri, Bursch, Cain, Carlos G. Briseño, Cassado, Caton, Cheong, Chow, Clausen, Cordes, Croxford, Franklin, Gautier, Ginhoux, Ginhoux, Ginhoux, Ginhoux, Gorman, Greter, Guilliams, Gwendalyn J. Randolph, Helft, Henri, Hertwig, Hoeffel, Hume, Iiizumi, Inaba, Jakubzick, Jakubzick, Jovanovic, Jörn C. Albring, Kaplan, Kelly, Kenneth M. Murphy, Ki-Wook Kim, Kingston, Kissenpfennig, Langlet, Lee, Li, Malay Haldar, Merad, Merad, Meredith, Miller, Mollah, Moriguchi, Plantinga, Poulin, Prachi Bagadia, Randolph, Ranganath, Ryan, Sallusto, Sarrazin, Sato-Nishiwaki, Satpathy, Satpathy, Schaller, Schlitzer, Schwanhäusser, Seré, Silberberg-Sinakin, Soucie, Srinivas, Sultana, Szymczak-Workman, Tamoutounour, Theresa L. Murphy, Vivek Durai, Wang, Xiaodi Wu, Zigmond   +78 more
core   +2 more sources

CD1a and langerin: acting as more than Langerhans cell markers [PDF]

Journal of Clinical Investigation, 2004
Langerhans cells (LCs) represent a unique DC subset populating the outermost body surface, i.e., the epidermis. Although CD1a and langerin (CD207) are used as specific markers to distinguish LCs from other DC subsets, their immunological functions have remained mostly unknown.
Norikatsu, Mizumoto, Akira, Takashima
openaire   +2 more sources

Murine Langerin+ dermal dendritic cells prime CD8+ T cells while Langerhans cells induce cross‐tolerance

EMBO Molecular Medicine, 2014
Skin dendritic cells (DCs) control the immunogenicity of cutaneously administered vaccines. Antigens targeted to DCs via the C‐type lectin Langerin/CD207 are cross‐presented to CD8+ T cells in vivo. We investigated the relative roles of Langerhans cells (
Vincent Flacher, Christoph H Tripp, David G Mairhofer, Ralph M Steinman, Patrizia Stoitzner, Juliana Idoyaga, Nikolaus Romani   +6 more
doaj   +1 more source

Genetic characterisation of Langerin gene in human immunodeficiency virus-1-infected women from Bahia, Brazil

Memorias do Instituto Oswaldo Cruz, 2014
Studies on human genetic variations are a useful source of knowledge about human immunodeficiency virus (HIV)-1 infection. The Langerin protein, found at the surface of Langerhans cells, has an important protective role in HIV-1 infection. Differences in
Giselle Calasans de Souza Costa, Jaqueline Goes Jesus, Filipe Ferreira de Almeida Rego, Edson Souza Santos, Bernardo Galvão-Castro, Marilda de Souza Gonçalves, Luiz Carlos Júnior Alcantara   +6 more
doaj   +1 more source

Identification and expression of mouse Langerin (CD207) in dendritic cells [PDF]

International Immunology, 2002
We have cloned the mouse homologue of human Langerin (h-Langerin), a type II transmembrane protein with a single external C-type lectin domain. Mouse Langerin (m-Langerin) displays 65 and 74% homologies in total amino acid and lectin domains with those of h-Langerin. The cognate mouse and rat genes were assigned to chromosome 6D1-D2 and chromosome 4q33
Takahara, Kazuhiko, Omatsu, Yoshiki, Yashima, Yusuke, Maeda, Yasuhiro, Tanaka, Shusaku, Iyoda, Tomonori, Clausen, Björn E., Matsubara, Kazumi, Letterio, John, Steinman, Ralph M., Matsuda, Yoichi, Inaba, Kayo, Clusen, Bjöern   +12 more
openaire   +3 more sources