Results 31 to 40 of about 5,672 (207)
Computational and experimental prediction of human C-type lectin receptor druggability
Frontiers in Immunology, 2014 Mammalian C-type lectin receptors are involved in many aspects of immune cell regulation such as pathogen recognition, clearance of apoptotic bodies and lymphocyte homing.
Jonas eAretz +8 more
doaj +1 more source
Carbohydrate-Dependent Binding of Langerin to SodC, a Cell Wall Glycoprotein of Mycobacterium leprae [PDF]
, 2014 Langerhans cells participate in the immune response in leprosy by their ability to activate T cells that recognize the pathogen, Mycobacterium leprae, in a langerin-dependent manner.
Robert L. Modlin +11 more
core +1 more source
Memorias do Instituto Oswaldo Cruz, 2014 Studies on human genetic variations are a useful source of knowledge about human immunodeficiency virus (HIV)-1 infection. The Langerin protein, found at the surface of Langerhans cells, has an important protective role in HIV-1 infection. Differences in
Giselle Calasans de Souza Costa +6 more
doaj +1 more source
Frontiers in Immunology, 2018 Bloodstream infections induce considerable morbidity, high mortality, and represent a significant burden of cost in health care; however, our understanding of the immune response to bacteremia is incomplete.
Kelly A. Prendergast +8 more
doaj +1 more source
Frontiers in Immunology, 2020 Sexually transmitted Hepatitis C virus (HCV) infections and high reinfections are a major concern amongst men who have sex with men (MSM) living with HIV-1 and HIV-negative MSM.
Bernadien M. Nijmeijer +8 more
doaj +1 more source
Alteration of the Langerin Oligomerization State Affects Birbeck Granule Formation [PDF]
Biophysical Journal, 2015 Langerin, a trimeric C-type lectin specifically expressed in Langerhans cells, has been reported to be a pathogen receptor through the recognition of glycan motifs by its three carbohydrate recognition domains (CRD). In the context of HIV-1 (human immunodeficiency virus-1) transmission, Langerhans cells of genital mucosa play a protective role by ...
Chabrol, Eric +9 more
openaire +3 more sources
Depletion of langerin+ cells enhances cutaneous wound healing [PDF]
Immunology, 2020 SummaryLangerin is a C‐type lectin receptor that is expressed on Langerhans cells and langerin‐positive dermal dendritic cells in the skin. Little is known about the function of langerin+ cells in wound healing. In this study, the effects of ablation of langerin+ cells on healing of a full‐thickness excision wound were investigated using the langerin ...
Aarthi Rajesh +6 more
openaire +2 more sources
mBio, 2019 Staphylococcus aureus is a major cause of skin and soft tissue infections and aggravator of the inflammatory skin disease atopic dermatitis (AD [eczema]). Epicutaneous exposure to S.
Rob van Dalen +12 more
doaj +1 more source
A population of Langerin-positive dendritic cells in murine Peyer's patches involved in sampling β-glucan microparticles. [PDF]
PLoS ONE, 2014 Glucan particles (GPs) are 2-4 μm hollow, porous shells composed of 1,3-β-D-glucan that have been effectively used for oral targeted-delivery of a wide range of payloads, including small molecules, siRNA, DNA, and protein antigens.
Magdia De Jesus +4 more
doaj +1 more source
CD1a and langerin: acting as more than Langerhans cell markers [PDF]
Journal of Clinical Investigation, 2004 Langerhans cells (LCs) represent a unique DC subset populating the outermost body surface, i.e., the epidermis. Although CD1a and langerin (CD207) are used as specific markers to distinguish LCs from other DC subsets, their immunological functions have remained mostly unknown.
Norikatsu, Mizumoto, Akira, Takashima
openaire +2 more sources