Results 21 to 30 of about 5,672 (207)

Ontogeny of Langerin/CD207 Expression in the Epidermis of Mice [PDF]

Journal of Investigative Dermatology, 2004
C-type lectin receptors help Langerhans cells (LC) to take up and process pathogens. Langerin/CD207 is a mannose-binding C-type lectin that is specifically expressed by LC. It is involved in antigen uptake in an as yet poorly defined way, and it is a major molecular constituent of Birbeck granules.
Tripp, Christoph H., Chang-Rodriguez, Souyet, Stoitzner, Patrizia, Holzmann, Sandra, Stössel, Hella, Douillard, Patrice, Saeland, Sem, Koch, Franz, Elbe-Bürger, Adelheid, Romani, Nikolaus   +9 more
openaire   +2 more sources

Rational Design of a DNA‐Scaffolded High‐Affinity Binder for Langerin [PDF]

Angewandte Chemie International Edition, 2020
AbstractBinders of langerin could target vaccines to Langerhans cells for improved therapeutic effect. Since langerin has low affinity for monovalent glycan ligands, highly multivalent presentation has previously been key for targeting. Aiming to reduce the amount of ligand required, we rationally designed molecularly defined high‐affinity binders ...
Bachem, Gunnar, Wamhoff, Eike-Christian, Silberreis, Kim, Kim, Dongyoon, Baukmann, Hannes, Fuchsberger, Felix F., Dernedde, Jens, Rademacher, Christoph, Seitz, Oliver, Fuchsberger, Felix   +9 more
openaire   +3 more sources

Image_2_A population of dermal Langerin+ dendritic cells promote the inflammation in mouse model of atopic dermatitis.tif

, 2022
Cutaneous dendritic cells (DCs) have been implicated in the pathogenesis of atopic dermatitis (AD). However, the specific role of different subsets of DCs has not been well defined.
Wei Li (7081), Chen Zhang (66790), Chunying Xiao (8612091), Jixin Gao (741196), Zhenlai Zhu (11936732), Yixin Luo (712865), Hui Fang (177012), Hongjiang Qiao (6558884), Gang Wang (36685), Meng Fu (307487)   +9 more
core   +1 more source

Image_1_A population of dermal Langerin+ dendritic cells promote the inflammation in mouse model of atopic dermatitis.tif

, 2022
Cutaneous dendritic cells (DCs) have been implicated in the pathogenesis of atopic dermatitis (AD). However, the specific role of different subsets of DCs has not been well defined.
Wei Li (7081), Chen Zhang (66790), Chunying Xiao (8612091), Jixin Gao (741196), Zhenlai Zhu (11936732), Yixin Luo (712865), Hui Fang (177012), Hongjiang Qiao (6558884), Gang Wang (36685), Meng Fu (307487)   +9 more
core   +1 more source

Usutu virus escapes langerin-induced restriction to productively infect human Langerhans cells, unlike West Nile virus

Emerging Microbes and Infections, 2022
Usutu virus (USUV) and West Nile virus (WNV) are phylogenetically close emerging arboviruses transmitted by mosquitoes, and constitute a global public health threat.
Marie-France Martin, Ghizlane Maarifi, Hervé Abiven, Marine Seffals, Nicolas Mouchet, Cécile Beck, Charles Bodet, Nicolas Lévèque, Nathalie J. Arhel, Fabien P. Blanchet, Yannick Simonin, Sébastien Nisole   +11 more
doaj   +1 more source

Adult-onset of Langerhans cell histiocytosis: a clinical case

Alʹmanah Kliničeskoj Mediciny, 2021
Langerhans cell histiocytosis is mainly diagnosed in children, and its manifestation in adult age is quite uncommon. Skin rashes may be non-specific and mimic a number of dermatoses.
Olga V. Chernysheva, Olga V. Dorokhina, Albina N. Khlebnikova, Elena V. Selezneva   +3 more
doaj   +1 more source

Host Langerin (CD207) is a receptor for Yersinia pestis phagocytosis and promotes dissemination [PDF]

, 2015
Yersinia pestis is a Gram-negative bacterium that causes plague. After Y. pestis overcomes the skin barrier, it encounters antigen-presenting cells (APCs), such as Langerhans and dendritic cells.
박채규
core   +3 more sources

Lipo-Based Vaccines as an Approach to Target Dendritic Cells for Induction of T- and iNKT Cell Responses

Frontiers in Immunology, 2020
In this study we developed a liposome-based vaccine containing palmitoylated synthetic long peptides (SLP) and alpha galactosylceramide (αGC) to specifically target dendritic cells (DC) for activation of both innate (invariant natural killer T-cells ...
Dorian A. Stolk, Aram de Haas, Jana Vree, Jana Vree, Sanne Duinkerken, Joyce Lübbers, Rieneke van de Ven, Rieneke van de Ven, Martino Ambrosini, Hakan Kalay, Sven Bruijns, Hans J. van der Vliet, Hans J. van der Vliet, Tanja D. de Gruijl, Yvette van Kooyk   +14 more
doaj   +1 more source

Effect of ultrasound treatment of the skin on activation of Langerhans cells and antibody production in rodents

Journal of Advanced Pharmaceutical Technology & Research, 2023
In this study, we investigated whether stimulating the skin with ultrasound (US) could activate Langerhans cells (LCs) – antigen-presenting cells in the epidermis and stimulate antibody production following the subcutaneous and intradermal injection of ...
Satoko Enjo, Yutaro Hazama, Soichiro Kimura, Yasunori Morimoto, Hideo Ueda   +4 more
doaj   +1 more source

Molecular mechanism of the pH-dependent calcium affinity in langerin [PDF]

, 2020
Abstract The C-type lectin receptor langerin plays a vital role in the mammalian defense against invading pathogens. Its function hinges on the affinity to its co-factor Ca 2+ which in turn is regulated by the pH.
Joswig, Jan-O., Anders, Jennifer, Zhang, Hengxi, Rademacher, Christoph, Keller, Bettina G.   +4 more
openaire   +1 more source