Results 21 to 30 of about 5,193 (199)

Mouse Lymphoid Tissue Contains Distinct Subsets of Langerin/CD207+ Dendritic Cells, Only One of Which Represents Epidermal-Derived Langerhans Cells

Journal of Investigative Dermatology, 2005
Langerin/CD207 is a C-type lectin associated with formation of Birbeck granules (BG) in Langerhans cells (LC). Here, we describe a monoclonal antibody (mAb 205C1) recognizing the extracellular domain of mouse langerin.
Patrizia Stoitzner, Christoph H Tripp, Nikolaus Romani   +2 more
exaly   +2 more sources

Targeting Langerhans cells via skin delivery of HIV Envelope enhances the antibody response to vaccination [PDF]

npj Vaccines
Targeting dendritic cells (DCs) with antigens is a promising approach to modulating T follicular helper (Tfh) cells and germinal center (GC) reactions, enhancing vaccine-induced adaptive immune responses, with preclinical studies highlighting a key role ...
Juliane S. Lanza, Adele Hammoudi, Joanna De Chiara, Mathieu Surenaud, Anaïs Kembou, Michela Esposito, Sandra Zurawski, Gerard Zurawski, Mireille Centlivre, Bernard Malissen, Véronique Godot, Yves Lévy, Sandrine Henri, Sylvain Cardinaud   +13 more
doaj   +2 more sources

A Specific, Glycomimetic Langerin Ligand for Human Langerhans Cell Targeting [PDF]

ACS Central Science, 2018
Langerhans cells are a subset of dendritic cells residing in the epidermis of the human skin. As such, they are key mediators of immune regulation and have emerged as prime targets for novel transcutaneous cancer vaccines.
Rentzsch, M., Bachem, G., Christoph Rademacher, Barbara Del Frari (2511379), Seitz, O., Hartmann, D., Oliver Seitz, Hermann, M., Fuchsberger, F., Felix F. Fuchsberger, van Sorge, Nina M, David Hartmann, Gunnar Bachem, Eike-Christian Wamhoff (2902202), Rentzsch, Mareike, Bellmann, L., Martin Hermann (614673), Hartmann, David, Martin Hermann, Schulze, Jessica, Schulze, J., Rob van Dalen (6689249), Fuchsberger, Felix F, Juliane Rademacher (6689246), Del Frari, Barbara, Barbara Del Frari, Wamhoff, Eike-Christian, van Dalen, Rob, Seitz, Oliver, Stoitzner, Patrizia, Eike-Christian Wamhoff, Jessica Schulze (6037745), David Hartmann (2256202), Rademacher, Juliane, Del Frari, B., Christoph Rademacher (1819219), Lydia Bellmann (6689237), Nina M. van Sorge (270975), Mareike Rentzsch (6689240), van Sorge, N., Bachem, Gunnar, Felix F. Fuchsberger (5883413), Bellmann, Lydia, Stoitzner, P., Gunnar Bachem (6689243), Rademacher, J., Nina M. van Sorge, Patrizia Stoitzner, Lydia Bellmann, Hermann, Martin, Rademacher, Christoph, Jessica Schulze, Rademacher, C., Rob van Dalen, van Dalen, R., Oliver Seitz (1504699), Patrizia Stoitzner (228449), Wamhoff, E., Juliane Rademacher   +58 more
core   +6 more sources

Identification and Characterization of Endogenous Langerin Ligands in Murine Extracellular Matrix [PDF]

Journal of Investigative Dermatology, 2006
Langerin is a C-type lectin that is expressed by Langerhans cells (LC) and related immune cells, and believed to play an important role in antigen recognition and uptake.
Tada, Yayoi, Lance A. Liotta, Liotta, Lance A., Riedl, Elisabeth, Lowenthal, Mark S., Crouch, Erika C., Briner, David M., Yayoi Tada, Mark S. Lowenthal, Erika C. Crouch, Mark C. Udey, David M. Briner, Elisabeth Riedl, Udey, Mark C.   +13 more
core   +3 more sources

Characterization of Langerin-Expressing Dendritic Cell Subsets in the Normal Cornea [PDF]

Investigative Opthalmology & Visual Science, 2011
Purpose. In addition to Langerhans cells (LCs), other dendritic cells (CD11c+) have recently been shown to express Langerin (c-type lectin). In skin, (non-LC) Langerin+ dendritic cells initiate adaptive immunity. However, whether such dendritic cells (
Takaaki Hattori, Hyunsoo Lee, Daniel R. Saban, Ueno, Hiroki, Chauhan, Sunil, Hattori, Takaaki, Saban, Daniel R., Lee, Hyunsoo, Sunil K. Chauhan, Dana, Reza, Hiroki Ueno, Reza Dana, Daniel H. Kaplan, Kaplan, Daniel H.   +13 more
core   +5 more sources

Calcium Competitive Inhibition of Langerin by Thiazolopyrimidinones. [PDF]

J Med Chem
C-Type lectins are a large family of carbohydrate-binding proteins. Langerin is a member of this family and is expressed by Langerhans cells, involved in pathogen recognition and innate immune activation, making it a target for small-molecule modulation in immunology and infectious diseases. We previously identified thiazolopyrimidinones as a series of
Ning Y, Efrém NL, Amoussa M, Turhan E, Zheng D, Lefèbre J, Ruwolt M, Neu U, Besch M, Loll B, Kurzbach D, Köhnke J, Nazaré M, Rademacher C.   +13 more
europepmc   +8 more sources

RARα supports the development of Langerhans cells and langerin-expressing conventional dendritic cells

Nature Communications, 2018
Langerhans cells (LC) and langerin-expressing conventional dendritic cells are made from distinct progenitors and enriched in the distinct microenvironments of the skin.
Seika Hashimoto-Hill, Leon Friesen, Sungtae Park, Suji Im, Mark H. Kaplan, Chang H. Kim   +5 more
doaj   +2 more sources

Peritumoural and Intratumoural Distribution of Langerhan Cell in Oral Squamous Cell Carcinoma and its Association with Known Prognostic Factors [PDF]

Journal of Clinical and Diagnostic Research, 2023
Introduction: Oral Squamous Cell Carcinoma (OSCC) accounts for about 2/3rd of the Head and Neck Squamous Cell Carcinomas (HNSCC). It is the sixth most common cancer worldwide and the third most common cancer in developing countries including India.
Sandhra Papparath Usman, Deepti Ramakrishnan, S Divya   +2 more
doaj   +1 more source

Trimeric Structure of Langerin [PDF]

Journal of Biological Chemistry, 2010
Langerin, an endocytic receptor of Langerhans cells, binds pathogens such as human immunodeficiency virus by recognition of surface glycoconjugates and mediates their internalization into Birbeck granules. Langerin has an extracellular region consisting of a C-type carbohydrate-recognition domain (CRD) and a neck region that stabilizes formation of ...
Feinberg, H, Powlesland, AS, Taylor, ME, Weis, WI   +3 more
openaire   +3 more sources

Rational Design of a DNA‐Scaffolded High‐Affinity Binder for Langerin [PDF]

Angewandte Chemie International Edition, 2020
AbstractBinders of langerin could target vaccines to Langerhans cells for improved therapeutic effect. Since langerin has low affinity for monovalent glycan ligands, highly multivalent presentation has previously been key for targeting. Aiming to reduce the amount of ligand required, we rationally designed molecularly defined high‐affinity binders ...
Bachem, Gunnar, Wamhoff, Eike-Christian, Silberreis, Kim, Kim, Dongyoon, Baukmann, Hannes, Fuchsberger, Felix F., Dernedde, Jens, Rademacher, Christoph, Seitz, Oliver, Fuchsberger, Felix   +9 more
openaire   +3 more sources