Results 1 to 10 of about 8,253 (208)

CD11b+ migratory dendritic cells mediate CD8 T cell cross-priming and cutaneous imprinting after topical immunization. [PDF]

PLoS ONE, 2014
Topical antigen application is a focus of current vaccine research. This immunization route mimics natural antigen exposure across a barrier tissue and generates T cells imprinted for skin-selective homing.
Suzanne T Nizza, James J Campbell
doaj   +20 more sources

A population of dermal Langerin+ dendritic cells promote the inflammation in mouse model of atopic dermatitis

Frontiers in Immunology, 2022
Cutaneous dendritic cells (DCs) have been implicated in the pathogenesis of atopic dermatitis (AD). However, the specific role of different subsets of DCs has not been well defined.
Wei Li, Chunying Xiao, JiXin Gao
exaly   +3 more sources

Langerin–Heparin Interaction: Two Binding Sites for Small and Large Ligands As Revealed by a Combination of NMR Spectroscopy and Cross-Linking Mapping Experiments [PDF]

Journal of the American Chemical Society, 2015
Langerin is a C-type lectin present on Langerhans cells that mediates capture of pathogens in a carbohydrate-dependent manner, leading to subsequent internalization and elimination in the cellular organelles called Birbeck granules.
Juan C Muñoz-García, Romain R Vivès, José L De Paz   +2 more
exaly   +8 more sources

Computational and experimental prediction of human C-type lectin receptor druggability [PDF]

Frontiers in Immunology, 2014
Mammalian C-type lectin receptors are involved in many aspects of immune cell regulation such as pathogen recognition, clearance of apoptotic bodies and lymphocyte homing.
Jonas eAretz, Jonas eAretz, Eike-Christian eWamhoff, Eike-Christian eWamhoff, Jonas eHanske, Jonas eHanske, Dario eHeymann, Christoph eRademacher, Christoph eRademacher   +8 more
doaj   +3 more sources

Recognition of Staphylococcus aureus by the pattern recognition molecules langerin, mannan-binding lectin, and surfactant protein D: the influence of capsular polysaccharides and wall teichoic acid [PDF]

Frontiers in Immunology
The innate immune system plays a critical role in the rapid recognition and elimination of pathogens through pattern recognition receptors (PRRs). Among these PRRs are the C-type lectins (CTLs) langerin, mannan-binding lectin (MBL), and surfactant ...
Kirstine Mejlstrup Hymøller, Kirstine Mejlstrup Hymøller, Stig Hill Christiansen, Stig Hill Christiansen, Anders Grønnegaard Schlosser, Uffe B. Skov Sørensen, Jean C. Lee, Steffen Thiel, Steffen Thiel   +8 more
doaj   +2 more sources

Langerhans Cells: Sensing the Environment in Health and Disease [PDF]

Frontiers in Immunology, 2018
In the last few decades, our understanding of Langerhans cells (LCs) has drastically changed based on novel findings regarding the developmental origin and biological functions of these epidermis-specific resident immune cells.
Julie Deckers, Julie Deckers, Hamida Hammad, Hamida Hammad, Esther Hoste, Esther Hoste   +5 more
doaj   +3 more sources

Targeting Langerhans cells via skin delivery of HIV Envelope enhances the antibody response to vaccination [PDF]

npj Vaccines
Targeting dendritic cells (DCs) with antigens is a promising approach to modulating T follicular helper (Tfh) cells and germinal center (GC) reactions, enhancing vaccine-induced adaptive immune responses, with preclinical studies highlighting a key role ...
Juliane S. Lanza, Adele Hammoudi, Joanna De Chiara, Mathieu Surenaud, Anaïs Kembou, Michela Esposito, Sandra Zurawski, Gerard Zurawski, Mireille Centlivre, Bernard Malissen, Véronique Godot, Yves Lévy, Sandrine Henri, Sylvain Cardinaud   +13 more
doaj   +2 more sources

Unraveling cutaneous histiocytosis: insights into histology, pathogenesis, diagnosis, and treatment pitfalls [PDF]

Frontiers in Medicine
Histiocytoses represent a group of diverse rare disorders characterized by the abnormal accumulation of cells derived from the mononuclear phagocyte system in various tissues and organs.
Lucian G. Scurtu, Lucian G. Scurtu, Francesca Scurtu, Francesca Scurtu, Olga Simionescu, Olga Simionescu   +5 more
doaj   +2 more sources

Peritumoural and Intratumoural Distribution of Langerhan Cell in Oral Squamous Cell Carcinoma and its Association with Known Prognostic Factors [PDF]

Journal of Clinical and Diagnostic Research, 2023
Introduction: Oral Squamous Cell Carcinoma (OSCC) accounts for about 2/3rd of the Head and Neck Squamous Cell Carcinomas (HNSCC). It is the sixth most common cancer worldwide and the third most common cancer in developing countries including India.
Sandhra Papparath Usman, Deepti Ramakrishnan, S Divya   +2 more
doaj   +1 more source

Glycosaminoglycans are interactants of Langerin: comparison with gp120 highlights an unexpected calcium-independent binding mode. [PDF]

PLoS ONE, 2012
Langerin is a C-type lectin specifically expressed in Langerhans cells. As recently shown for HIV, Langerin is thought to capture pathogens and mediate their internalisation into Birbeck Granules for elimination.
Eric Chabrol, Alessandra Nurisso, Antoine Daina, Emilie Vassal-Stermann, Michel Thepaut, Eric Girard, Romain R Vivès, Franck Fieschi   +7 more
doaj   +1 more source