Langerin-expressing dendritic cells in pulmonary immune-related diseases [PDF]
Frontiers in Medicine, 2022 Dendritic cells (DCs) are “frontline” immune cells dedicated to antigen presentation. They serve as an important bridge connecting innate and adaptive immunity, and express various receptors for antigen capture.
Shurui Xuan +5 more
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Frontiers in Immunology, 2022 Cutaneous dendritic cells (DCs) have been implicated in the pathogenesis of atopic dermatitis (AD). However, the specific role of different subsets of DCs has not been well defined.
Chunying Xiao, Zhaohua Zhu, Jixin Gao
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Glycosaminoglycans are interactants of Langerin: comparison with gp120 highlights an unexpected calcium-independent binding mode. [PDF]
PLoS ONE, 2012 Langerin is a C-type lectin specifically expressed in Langerhans cells. As recently shown for HIV, Langerin is thought to capture pathogens and mediate their internalisation into Birbeck Granules for elimination.
Eric Chabrol +7 more
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Murine Langerin+ dermal dendritic cells prime CD8+ T cells while Langerhans cells induce cross‐tolerance [PDF]
EMBO Molecular Medicine, 2014 Skin dendritic cells (DCs) control the immunogenicity of cutaneously administered vaccines. Antigens targeted to DCs via the C‐type lectin Langerin/CD207 are cross‐presented to CD8+ T cells in vivo. We investigated the relative roles of Langerhans cells (
Vincent Flacher +6 more
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ERDHEIM-Chester Disease: Two Fatal Cases With Unusual Presentations. [PDF]
Clin Case RepFluorodeoxyglucose positron emission tomography‐computed tomography (FDG PET‐CT) demonstrated markedly increased metabolic activity in serosal surfaces including pericardium, pleura, and renal fascia, as well as diffuse uptake along vascular walls, particularly the entire aorta.
Daniel Andres RV +2 more
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Genetic characterisation of Langerin gene in human immunodeficiency virus-1-infected women from Bahia, Brazil [PDF]
Memorias do Instituto Oswaldo Cruz, 2014 Studies on human genetic variations are a useful source of knowledge about human immunodeficiency virus (HIV)-1 infection. The Langerin protein, found at the surface of Langerhans cells, has an important protective role in HIV-1 infection. Differences in
Giselle Calasans de Souza Costa +6 more
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Targeting of the C-Type Lectin Receptor Langerin Using Bifunctional Mannosylated Antigens
Frontiers in Cell and Developmental Biology, 2020 Langerhans cells (LCs) are antigen-presenting cells that reside in the skin. They uniquely express high levels of the C-type lectin receptor Langerin (CD207), which is an attractive target for antigen delivery in immunotherapeutic vaccination strategies ...
R J Eveline Li +2 more
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Pulmonary Langerhans Cell Histiocytosis Presenting as Multiple Obstructing Bronchial Lesions and Pulmonary Masses. [PDF]
Clin Respir JWe describe a case of PLCH presenting as multiple obstructing bronchial lesions and pulmonary masses in a 36‐year‐old man. To our knowledge, this is the first report of PLCH presenting as bilateral hilar masses and airway obstructive lesions. ABSTRACT Pulmonary Langerhans cell histiocytosis is a rare lung disease, which was previously classified as ...
Fan J, Liu C, Yang Z, Sun D.
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Proceedings of the National Academy of Sciences of the United States of America, 2009 A new langerin(+) DC subset has recently been identified in murine dermis (langerin(+) dDC), but the lineage and functional relationships between these cells and langerin(+) epidermal Langerhans cells (LC) are incompletely characterized.
Keisuke Nagao +2 more
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Recognition of Staphylococcus aureus by the pattern recognition molecules langerin, mannan-binding lectin, and surfactant protein D: the influence of capsular polysaccharides and wall teichoic acid [PDF]
Frontiers in ImmunologyThe innate immune system plays a critical role in the rapid recognition and elimination of pathogens through pattern recognition receptors (PRRs). Among these PRRs are the C-type lectins (CTLs) langerin, mannan-binding lectin (MBL), and surfactant ...
Kirstine Mejlstrup Hymøller +8 more
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