Identification and Characterization of Endogenous Langerin Ligands in Murine Extracellular Matrix [PDF]
Journal of Investigative Dermatology, 2006 Langerin is a C-type lectin that is expressed by Langerhans cells (LC) and related immune cells, and believed to play an important role in antigen recognition and uptake. To determine if Langerin has endogenous ligands, we generated S protein binding, bacterial recombinant, mouse soluble Langerin, and utilized it as a probe.
Tada, Yayoi +6 more
openaire +2 more sources
Role of langerin+ cells in skin pathologies
, 2021 Langerhans cells (LCs) are epidermal immune cells that express C-type lectin receptor langerin along with a subset of dermal dendritic cells. Langerin+ cells play a pivotal role in skin immunity. Previous research has suggested that LC may be involved in
Rajesh, Aarthi
core +1 more source
Blood-derived dermal langerin+ dendritic cells survey the skin in the steady state. [PDF]
, 2007 International audienceLangerin is a C-type lectin receptor that recognizes glycosylated patterns on pathogens. Langerin is used to identify human and mouse epidermal Langerhans cells (LCs), as well as migratory LCs in the dermis and the skin draining ...
Leboeuf, Marylene +25 more
core +1 more source
Batf3-dependent CD11b(low/-) peripheral dendritic cells are GM-CSF-independent and are not required for Th cell priming after subcutaneous immunization. [PDF]
PLoS ONE, 2011 Dendritic cells (DCs) subsets differ in precursor cell of origin, functional properties, requirements for growth factors, and dependence on transcription factors.
Brian T Edelson +9 more
doaj +1 more source
Hepatic Langerhans cell histiocytosis: Report of a rare case
Human Pathology Reports, 2023 Langerhans cell histiocytosis (LCH) is a rare neoplastic disease characterized by abnormal proliferation of Langerhans cells infiltrating various organs, resulting in organ dysfunction.
Renling Yao, Jun Chen, Jie Li
doaj +1 more source
Langerin, the “Catcher in the Rye”: An important receptor for pathogens on Langerhans cells [PDF]
European Journal of Immunology, 2011 AbstractLangerhans cells (LCs) are a distinct subset of DCs that resides in the epidermis and other epithelia. They are potent antigen‐presenting cells and strong inducers of T‐cell responses. Like other DC types, LCs express C‐type lectins that serve as antigen/pathogen uptake receptors, with Langerin/CD207 being the characteristic LC C‐type lectin ...
Patrizia, Stoitzner, Nikolaus, Romani
openaire +2 more sources
The Essential Role of anxA2 in Langerhans Cell Birbeck Granules Formation
Cells, 2020 Langerhans cells (LC) are the resident antigen presenting cells of the mucosal epithelium and play an essential role in initiating immune responses.
Shantae M. Thornton +7 more
doaj +1 more source
Activin A induces Langerhans cell differentiation in vitro and in human skin explants. [PDF]
PLoS ONE, 2008 Langerhans cells (LC) represent a well characterized subset of dendritic cells located in the epidermis of skin and mucosae. In vivo, they originate from resident and blood-borne precursors in the presence of keratinocyte-derived TGFbeta.
Tiziana Musso +14 more
doaj +1 more source
Identification and Characterization of an Alternatively Spliced Isoform of Mouse Langerin/CD207 [PDF]
Journal of Investigative Dermatology, 2004 The mouse homologue of human Langerin (CD207), a novel Langerhans cells (LC)-restricted C-type lectin that likely participates in antigen recognition and uptake, has been recently identified. In this study, we isolated the mouse Langerin cDNA from murine fetal skin-derived dendritic cells (FSDDC) by subtractive cloning and rapid amplification of cDNA ...
Riedl, Elisabeth +2 more
openaire +3 more sources
Frontiers in Immunology, 2018 Peri-implantitis is a destructive inflammatory process affecting tissues surrounding dental implants and it is considered a new global health concern.
Oded Heyman +10 more
doaj +1 more source