Results 41 to 50 of about 8,253 (208)

Langerin+ CD8α+ Dendritic Cells Drive Early CD8+ T Cell Activation and IL-12 Production During Systemic Bacterial Infection

Frontiers in Immunology, 2018
Bloodstream infections induce considerable morbidity, high mortality, and represent a significant burden of cost in health care; however, our understanding of the immune response to bacteremia is incomplete.
Kelly A. Prendergast, Kelly A. Prendergast, Naomi J. Daniels, Troels R. Petersen, Ian F. Hermans, Ian F. Hermans, Ian F. Hermans, Joanna R. Kirman, Joanna R. Kirman   +8 more
doaj   +1 more source

Syndecan 4 Upregulation on Activated Langerhans Cells Counteracts Langerin Restriction to Facilitate Hepatitis C Virus Transmission

Frontiers in Immunology, 2020
Sexually transmitted Hepatitis C virus (HCV) infections and high reinfections are a major concern amongst men who have sex with men (MSM) living with HIV-1 and HIV-negative MSM.
Bernadien M. Nijmeijer, Julia Eder, Catharina J. M. Langedijk, Tanja M. Kaptein, Sofie Meeussen, Pascale Zimmermann, Pascale Zimmermann, Carla M. S. Ribeiro, Teunis B. H. Geijtenbeek   +8 more
doaj   +1 more source

Host Langerin (CD207) is a receptor for Yersinia pestis phagocytosis and promotes dissemination [PDF]

, 2015
Yersinia pestis is a Gram-negative bacterium that causes plague. After Y. pestis overcomes the skin barrier, it encounters antigen-presenting cells (APCs), such as Langerhans and dendritic cells.
Anyi Li, Chae G Park, Cheolho Cheong, Gottfried RS., Gregory V Plano, Honghui Ding, Hongping Huang, John D Klena, Kun Yang, Lianxu Xia, Lin Zhang, Lingyu Jiang, Mikael Skurnik, Pei Zhang, Sara S Bartra, Shaogang Wang, Shusheng Zhang, Silvia Bulgheresi, Tie Chen, Yingxia He, Yiping Wu   +20 more
core   +1 more source

Langerin Expressing Cells Promote Skin Immune Responses under Defined Conditions [PDF]

The Journal of Immunology, 2008
Abstract There are conflicting data in the literature regarding the role of epidermal Langerhans cells (LC) in promoting skin immune responses. On one hand, LC can be extremely potent APCs in vitro, and are thought to be involved in contact hypersensitivity (CHS).
Wang, Liangchun, Bursch, Laura S, Kissenpfennig, Adrien, Malissen, Bernard, Jameson, Stephen C, Hogquist, Kristin A   +5 more
openaire   +3 more sources

Molecular mechanism of the pH-dependent calcium affinity in langerin [PDF]

, 2020
AbstractThe C-type lectin receptor langerin plays a vital role in the mammalian defense against invading pathogens. Its function hinges on the affinity to its co-factor Ca2+which in turn is regulated by the pH. We studied the structural consequences of protonating the allosteric pH-sensor histidine H294 by molecular dynamics simulations (total ...
Joswig, Jan-O., Anders, Jennifer, Zhang, Hengxi, Rademacher, Christoph, Keller, Bettina G.   +4 more
openaire   +1 more source

Langerhans Cells Sense Staphylococcus aureus Wall Teichoic Acid through Langerin To Induce Inflammatory Responses

mBio, 2019
Staphylococcus aureus is a major cause of skin and soft tissue infections and aggravator of the inflammatory skin disease atopic dermatitis (AD [eczema]). Epicutaneous exposure to S.
Rob van Dalen, Jacinto S. De La Cruz Diaz, Matevž Rumpret, Felix F. Fuchsberger, Nienke H. van Teijlingen, Jonas Hanske, Christoph Rademacher, Teunis B. H. Geijtenbeek, Jos A. G. van Strijp, Christopher Weidenmaier, Andreas Peschel, Daniel H. Kaplan, Nina M. van Sorge   +12 more
doaj   +1 more source

A population of Langerin-positive dendritic cells in murine Peyer's patches involved in sampling β-glucan microparticles. [PDF]

PLoS ONE, 2014
Glucan particles (GPs) are 2-4 μm hollow, porous shells composed of 1,3-β-D-glucan that have been effectively used for oral targeted-delivery of a wide range of payloads, including small molecules, siRNA, DNA, and protein antigens.
Magdia De Jesus, Gary R Ostroff, Stuart M Levitz, Toni R Bartling, Nicholas J Mantis   +4 more
doaj   +1 more source

Hypomorphic mutation in the RAG2 gene affects dendritic cell distribution and migration. [PDF]

, 2013
In Omenn syndrome, altered dendritic cell distribution and impaired migration represent an additional level of immune dysregulation, contributing to the pathogenesis of autoimmunity. OS is a severe combined immunodeficiency characterized by erythrodermia
Anselmo A, Cassani B, Del Prete A, Fontana E, Maina V, Mantero S, Marrella V, Poliani PL, Sozzani S, Vezzoni P, Villa A.   +10 more
core   +1 more source

HIV target cells and innate immune factors in the human female genital tract [PDF]

, 2011
World-wide, human immunodeficiency virus (HIV) transmission most often takes place in the genital tract during heterosexual intercourse, but the site where HIV most commonly establishes primary infection in the female genital tract remains unknown ...
Kaldensjö, Tove
core   +1 more source

Increase of DC-LAMP+ mature dendritic cell subsets in dermatopathic lymphadenitis of mycosis fungoides [PDF]

, 2014
Background: Little is known about the immunological milieu of the skin-draining lymph nodes (LNs) in mycosis fungoides (MF). Objectives: We studied dendritic cell (DC) subsets in the dermatopathic lymphadenitis of MF patients.
Aoyama, Yumi, Asagoe, Kenji, Hamada, Toshihisa, Iwatsuki, Keiji, Mizuno-Ikeda, Kazuko, Otsuka, Masaki, Tada, Kotaro, Umemura, Hiroshi, Yamasaki, Osamu   +8 more
core   +1 more source