Results 11 to 20 of about 5,193 (199)

Langerin is a natural barrier to HIV-1 transmission by Langerhans cells

Nature Medicine, 2007
Human immunodeficiency virus-1 (HIV-1) is primarily transmitted sexually. Dendritic cells (DCs) in the subepithelium transmit HIV-1 to T cells through the C-type lectin DC-specific intercellular adhesion molecule (ICAM)-3-grabbing nonintegrin (DC-SIGN ...
Lot De Witte, Alexey A Nabatov, Marjorie Pion   +2 more
exaly   +7 more sources

Identification and expression of mouse Langerin (CD207) in dendritic cells [PDF]

International Immunology, 2002
We have cloned the mouse homologue of human Langerin (h-Langerin), a type II transmembrane protein with a single external C-type lectin domain. Mouse Langerin (m-Langerin) displays 65 and 74% homologies in total amino acid and lectin domains with those ...
Matsuda, Yoichi, Inaba, Kayo, Omatsu, Yoshiki, Letterio, John, Matsubara, Kazumi, Iyoda, Tomonori, Clausen, Björn E., Tanaka, Shusaku, Clusen, Bjöern, Yashima, Yusuke, Steinman, Ralph M., Maeda, Yasuhiro, Takahara, Kazuhiko   +12 more
core   +5 more sources

Ontogeny of Langerin/CD207 Expression in the Epidermis of Mice [PDF]

Journal of Investigative Dermatology, 2004
C-type lectin receptors help Langerhans cells (LC) to take up and process pathogens. Langerin/CD207 is a mannose-binding C-type lectin that is specifically expressed by LC.
Adelheid Elbe-Bürger, Koch, Franz, Souyet Chang-Rodriguez, Patrizia Stoitzner, Sandra Holzmann, Holzmann, Sandra, Christoph H. Tripp, Nikolaus Romani, Sem Saeland, Chang-Rodriguez, Souyet, Franz Koch, Douillard, Patrice, Patrice Douillard, Hella Stössel, Stoitzner, Patrizia, Stössel, Hella, Saeland, Sem, Romani, Nikolaus, Tripp, Christoph H., Elbe-Bürger, Adelheid   +19 more
core   +3 more sources

Identification of a novel population of Langerin+ dendritic cells. [PDF]

The Journal of Experimental Medicine, 2007
International audienceLangerhans cells (LCs) are antigen-presenting cells that reside in the epidermis of the skin and traffic to lymph nodes (LNs).
Bernard Malissen, Kristin A. Hogquist, Malissen, Bernard, Liangchun Wang, Wang, Liangchun, Kaplan, Daniel H, Adrien Kissenpfennig, Botond Igyarto, Daniel H. Kaplan, Laura S. Bursch, Igyarto, Botond, Bursch, Laura S, Kissenpfennig, Adrien, Hogquist, Kristin A   +13 more
core   +3 more sources

Langerin-Heparin Interaction: Analysis of the Binding to the Non-Lectin Site [PDF]

Natural Product Communications, 2019
Langerin is a C-type lectin involved in the immune response that forms a trimer in its active form. It can interact with carbohydrates using 2 sites with different selectivity, the C-lectin site, a Ca 2+ -mediated binding, and the cleft between chains ...
M. José García-Jiménez, Francisco Corzana, José L. De Paz, Pedro M. Nieto   +3 more
doaj   +3 more sources

Asymmetrically Branched Precision Glycooligomers Targeting Langerin

Biomacromolecules, 2019
Asymmetrically branched precision glycooligomers are synthesized by solid-phase polymer synthesis for studying multivalent carbohydrate–protein interactions.
Christoph Rademacher, Andrea Grafmüller, Christoph Rademacher (1819219), Kira Neuhaus, Andrea Grafmüller (1372380), Laura Hartmann (1554037), Laura Hartmann, Eike-Christian Wamhoff (2902202), Eike-Christian Wamhoff, Tanja Freichel, Kira Neuhaus (7542077), Tanja Freichel (3727873)   +11 more
core   +4 more sources

Reproduction of Langerin/CD207 Traffic and Birbeck Granule Formation in a Human Cell Line Model

Journal of Investigative Dermatology, 2004
Birbeck granules (BG) are organelles specific to Langerhans cells (LCs), which form where the C-type lectin Langerin accumulates. Their function remains obscure due to morphologic and dynamic alterations induced by maturation of isolated LC.
Ray Mcdermott, Huguette Bausinger, Daniele Spehner   +2 more
exaly   +2 more sources

Identification and Characterization of an Alternatively Spliced Isoform of Mouse Langerin/CD207 [PDF]

Journal of Investigative Dermatology, 2004
The mouse homologue of human Langerin (CD207), a novel Langerhans cells (LC)-restricted C-type lectin that likely participates in antigen recognition and uptake, has been recently identified. In this study, we isolated the mouse Langerin cDNA from murine
Tada, Yayoi, Yayoi Tada, Mark C. Udey, Elisabeth Riedl, Riedl, Elisabeth, Udey, Mark C.   +5 more
core   +3 more sources

A common genetic variation in Langerin (CD207) compromises cellular uptake of Staphylococcus aureus [PDF]

Journal of Biological Chemistry, 2020
Langerhans cells are key sentinel cells of the skin and mucosal lining. They sense microorganisms through their repertoire of pattern-recognition receptors to mount and direct appropriate immune responses.
van Strijp, J., Fuchsberger, Felix F., Rademacher, Christoph, van Sorge, Nina M., Rademacher, C., van Strijp, Jos A. G., van Dalen, Rob, Fuchsberger, F., van Sorge, N., van Dalen, R.   +9 more
core   +5 more sources

Murine Intestinal Neonatal and Adult Dendritic Cell Subset Migration and Activation Characteristics in Response to Toll-Like Receptor Stimulation Through MyD88. [PDF]

Scand J Immunol
Despite their importance, dendritic cell subsets are not well characterised in neonates. We here provide fundamental information on the abundance and phenotype of small‐intestinal neonatal DCs and assess the role of MyD88 in neonatal and adult DC migration in response to several toll‐like receptor ligands.
Muleta KG, Holst S, Garcias López A, Chakraborty S, da Silva C, Cunningham AF, Ulmert I, Nakawesi J, Hütter J, Lahl K.   +9 more
europepmc   +2 more sources