Results 11 to 20 of about 5,672 (207)

Identification and expression of mouse Langerin (CD207) in dendritic cells [PDF]

International Immunology, 2002
We have cloned the mouse homologue of human Langerin (h-Langerin), a type II transmembrane protein with a single external C-type lectin domain. Mouse Langerin (m-Langerin) displays 65 and 74% homologies in total amino acid and lectin domains with those of h-Langerin. The cognate mouse and rat genes were assigned to chromosome 6D1-D2 and chromosome 4q33
Takahara, Kazuhiko, Omatsu, Yoshiki, Yashima, Yusuke, Maeda, Yasuhiro, Tanaka, Shusaku, Iyoda, Tomonori, Clausen, Björn E., Matsubara, Kazumi, Letterio, John, Steinman, Ralph M., Matsuda, Yoichi, Inaba, Kayo, Clusen, Bjöern   +12 more
openaire   +4 more sources

Murine Langerin+ dermal dendritic cells prime CD8+ T cells while Langerhans cells induce cross‐tolerance [PDF]

EMBO Molecular Medicine, 2014
Skin dendritic cells (DCs) control the immunogenicity of cutaneously administered vaccines. Antigens targeted to DCs via the C‐type lectin Langerin/CD207 are cross‐presented to CD8+ T cells in vivo. We investigated the relative roles of Langerhans cells (
Vincent Flacher, Christoph H Tripp, David G Mairhofer, Ralph M Steinman, Patrizia Stoitzner, Juliana Idoyaga, Nikolaus Romani   +6 more
doaj   +2 more sources

Characterization of Langerin-Expressing Dendritic Cell Subsets in the Normal Cornea [PDF]

Investigative Opthalmology & Visual Science, 2011
In addition to Langerhans cells (LCs), other dendritic cells (CD11c(+)) have recently been shown to express Langerin (c-type lectin). In skin, (non-LC) Langerin+ dendritic cells initiate adaptive immunity. However, whether such dendritic cells (DC) reside in the cornea, an immune-privileged tissue, is unknown.Normal C57BL/6 corneas were harvested for ...
Hattori, Takaaki, Chauhan, Sunil, Lee, Hyunsoo, Ueno, Hiroki, Dana, Reza, Kaplan, Daniel H., Saban, Daniel R.   +6 more
openaire   +5 more sources

A Specific, Glycomimetic Langerin Ligand for Human Langerhans Cell Targeting [PDF]

ACS Central Science, 2019
Langerhans cells are a subset of dendritic cells residing in the epidermis of the human skin. As such, they are key mediators of immune regulation and have emerged as prime targets for novel transcutaneous cancer vaccines. Importantly, the induction of protective T cell immunity by these vaccines requires the efficient and specific delivery of both ...
Eike-Christian Wamhoff, Jessica Schulze, Lydia Bellmann, Mareike Rentzsch, Gunnar Bachem, Felix F. Fuchsberger, Juliane Rademacher, Martin Hermann, Barbara Del Frari, Rob van Dalen, David Hartmann, Nina M. van Sorge, Oliver Seitz, Patrizia Stoitzner, Christoph Rademacher   +14 more
core   +11 more sources

Langerin-Heparin Interaction: Analysis of the Binding to the Non-Lectin Site [PDF]

Natural Product Communications, 2019
Langerin is a C-type lectin involved in the immune response that forms a trimer in its active form. It can interact with carbohydrates using 2 sites with different selectivity, the C-lectin site, a Ca 2+ -mediated binding, and the cleft between chains ...
M. José García-Jiménez, Francisco Corzana, José L. De Paz, Pedro M. Nieto   +3 more
doaj   +3 more sources

Asymmetrically Branched Precision Glycooligomers Targeting Langerin

Biomacromolecules, 2019
Asymmetrically branched precision glycooligomers are synthesized by solid-phase polymer synthesis for studying multivalent carbohydrate-protein interactions. Through the stepwise assembly of Fmoc-protected oligo(amidoamine) building blocks and Fmoc/Dde-protected lysine, straightforward variation of structural parameters such as the number and length of
Kira Neuhaus, Eike-Christian Wamhoff, Tanja Freichel, Andrea Grafmüller, Christoph Rademacher, Laura Hartmann   +5 more
openaire   +4 more sources

RARα supports the development of Langerhans cells and langerin-expressing conventional dendritic cells

Nature Communications, 2018
Langerhans cells (LC) and langerin-expressing conventional dendritic cells are made from distinct progenitors and enriched in the distinct microenvironments of the skin.
Seika Hashimoto-Hill, Leon Friesen, Sungtae Park, Suji Im, Mark H. Kaplan, Chang H. Kim   +5 more
doaj   +2 more sources

Calcium Competitive Inhibition of Langerin by Thiazolopyrimidinones. [PDF]

J Med Chem
Abstract C-Type lectins are a large family of carbohydrate-binding proteins. Langerin is a member of this family and is expressed by Langerhans cells, involved in pathogen recognition and innate immune activation, making it a target for small-molecule modulation in immunology and infectious diseases.
Ning Y, Efrém NL, Amoussa M, Turhan E, Zheng D, Lefèbre J, Ruwolt M, Neu U, Besch M, Loll B, Kurzbach D, Köhnke J, Nazaré M, Rademacher C.   +13 more
europepmc   +8 more sources

Trimeric Structure of Langerin [PDF]

Journal of Biological Chemistry, 2010
Langerin, an endocytic receptor of Langerhans cells, binds pathogens such as human immunodeficiency virus by recognition of surface glycoconjugates and mediates their internalization into Birbeck granules. Langerin has an extracellular region consisting of a C-type carbohydrate-recognition domain (CRD) and a neck region that stabilizes formation of ...
Feinberg, H, Powlesland, AS, Taylor, ME, Weis, WI   +3 more
openaire   +3 more sources

Identification of a novel population of Langerin+ dendritic cells [PDF]

The Journal of Experimental Medicine, 2007
Langerhans cells (LCs) are antigen-presenting cells that reside in the epidermis of the skin and traffic to lymph nodes (LNs). The general role of these cells in skin immune responses is not clear because distinct models of LC depletion resulted in opposite conclusions about their role in contact hypersensitivity (CHS) responses.
Bursch, Laura S, Wang, Liangchun, Igyarto, Botond, Kissenpfennig, Adrien, Malissen, Bernard, Kaplan, Daniel H, Hogquist, Kristin A   +6 more
openaire   +2 more sources