Results 11 to 20 of about 8,253 (208)

Langerin-expressing dendritic cells in pulmonary immune-related diseases

Frontiers in Medicine, 2022
Dendritic cells (DCs) are “frontline” immune cells dedicated to antigen presentation. They serve as an important bridge connecting innate and adaptive immunity, and express various receptors for antigen capture.
Shurui Xuan, Yuebei Li, Yunhui Wu, Ian M. Adcock, Xiaoning Zeng, Xin Yao   +5 more
doaj   +5 more sources

Common Polymorphisms in Human Langerin Change Specificity for Glycan Ligands [PDF]

Journal of Biological Chemistry, 2013
Langerin, a C-type lectin on Langerhans cells, mediates carbohydrate-dependent uptake of pathogens in the first step of antigen presentation to the adaptive immune system. Langerin binds a diverse range of carbohydrates including high mannose structures,
Drickamer, K, Feinberg, H, Rowntree, TJW, Tan, SLW, Taylor, ME, Weis, WI   +5 more
core   +6 more sources

Targeting human langerin promotes HIV-1 specific humoral immune responses.

PLoS Pathogens, 2021
The main avenue for the development of an HIV-1 vaccine remains the induction of protective antibodies. A rationale approach is to target antigen to specific receptors on dendritic cells (DC) via fused monoclonal antibodies (mAb).
Jérôme Kervevan, Aurélie Bouteau, Juliane S Lanza, Adele Hammoudi, Sandra Zurawski, Mathieu Surenaud, Lydie Dieudonné, Marion Bonnet, Cécile Lefebvre, Hakim Hocini, Romain Marlin, Aurélie Guguin, Barbara Hersant, Oana Hermeziu, Elisabeth Menu, Christine Lacabaratz, Jean-Daniel Lelièvre, Gerard Zurawski, Véronique Godot, Sandrine Henri, Botond Z Igyártó, Yves Levy, Sylvain Cardinaud   +22 more
doaj   +5 more sources

Langerin-Heparin Interaction: Analysis of the Binding to the Non-Lectin Site [PDF]

Natural Product Communications, 2019
Langerin is a C-type lectin involved in the immune response that forms a trimer in its active form. It can interact with carbohydrates using 2 sites with different selectivity, the C-lectin site, a Ca 2+ -mediated binding, and the cleft between chains ...
M. José García-Jiménez, Francisco Corzana, José L. De Paz, Pedro M. Nieto   +3 more
doaj   +3 more sources

Calcium Competitive Inhibition of Langerin by Thiazolopyrimidinones. [PDF]

J Med Chem
Raw data associated with Ning Y. et al. 2025 J Med Chem.
Ning Y, Efrém NL, Amoussa M, Turhan E, Zheng D, Lefèbre J, Ruwolt M, Neu U, Besch M, Loll B, Kurzbach D, Köhnke J, Nazaré M, Rademacher C.   +13 more
europepmc   +4 more sources

Pheochromocytoma With Langerhans Cell Histiocytosis: A Rare Tumor-in-Tumor Case. [PDF]

Clin Case Rep
ABSTRACT Langerhans cell histiocytosis (LCH) occurring in a Pheochromocytoma in the adrenal gland is exceptionally rare and prone to misdiagnosis. The special coexistent tumors harbor distinct genetic mutations. This uncommon case could introduce novel considerations and a strong teaching message to all the clinicians and pathologists.
Lei C, Guo Y, Luo Y, Liang Q, Luo J.
europepmc   +2 more sources

Trimeric Structure of Langerin [PDF]

Journal of Biological Chemistry, 2010
Langerin, an endocytic receptor of Langerhans cells, binds pathogens such as human immunodeficiency virus by recognition of surface glycoconjugates and mediates their internalization into Birbeck granules. Langerin has an extracellular region consisting of a C-type carbohydrate-recognition domain (CRD) and a neck region that stabilizes formation of ...
Feinberg, H, Powlesland, AS, Taylor, ME, Weis, WI   +3 more
openaire   +4 more sources

Depletion of langerin⁺ cells enhances cutaneous wound healing [PDF]

Immunology, 2020
SummaryLangerin is a C‐type lectin receptor that is expressed on Langerhans cells and langerin‐positive dermal dendritic cells in the skin. Little is known about the function of langerin+ cells in wound healing. In this study, the effects of ablation of langerin+ cells on healing of a full‐thickness excision wound were investigated using the langerin ...
Aarthi Rajesh, Gabriella Stuart, Nicola Real, Jenny Ahn, Allison Tschirley, Lyn Wise, Merilyn Hibma   +6 more
openaire   +2 more sources

Birbeck granule-like "organized smooth endoplasmic reticulum" resulting from the expression of a cytoplasmic YFP-tagged langerin. [PDF]

PLoS ONE, 2013
Langerin is required for the biogenesis of Birbeck granules (BGs), the characteristic organelles of Langerhans cells. We previously used a Langerin-YFP fusion protein having a C-terminal luminal YFP tag to dynamically decipher the molecular and cellular ...
Cédric Lenormand, Coralie Spiegelhalter, Bertrand Cinquin, Sabine Bardin, Huguette Bausinger, Catherine Angénieux, Anita Eckly, Fabienne Proamer, David Wall, Ben Lich, Sylvie Tourne, Daniel Hanau, Yannick Schwab, Jean Salamero, Henri de la Salle   +14 more
doaj   +1 more source

Murine Intestinal Neonatal and Adult Dendritic Cell Subset Migration and Activation Characteristics in Response to Toll-Like Receptor Stimulation Through MyD88. [PDF]

Scand J Immunol
Despite their importance, dendritic cell subsets are not well characterised in neonates. We here provide fundamental information on the abundance and phenotype of small‐intestinal neonatal DCs and assess the role of MyD88 in neonatal and adult DC migration in response to several toll‐like receptor ligands.
Muleta KG, Holst S, Garcias López A, Chakraborty S, da Silva C, Cunningham AF, Ulmert I, Nakawesi J, Hütter J, Lahl K.   +9 more
europepmc   +2 more sources