Results 81 to 90 of about 17,586 (206)

Impaired hepatic drug and steroid metabolism in congenital adrenal hyperplasia due to P450 oxidoreductase deficiency [PDF]

, 2010
Objective: Patients with congenital adrenal hyperplasia due to P450 oxidoreductase (POR) deficiency(ORD) present with disordered sex development and glucocorticoid deficiency.
Arlt, Bebia, Chang, de Morais, Dominique Maiter, Dorota Tomalik-Scharte, Fl  ck, Fuhr, Gomes, Hannah E Ivison, Henderson, Jetter, Julia Kirchheiner, Kelley, Kirchheiner, Kranendonk, Nebert, Nicolo, Parkinson, Porter, Ribes, Sachse, Tantcheva-Po  r, Tomalik-Scharte, Uwe Fuhr, Wiebke Arlt   +25 more
core   +2 more sources

In silico prediction of ATTAF-1 and ATTAF-2 selectivity towards human/fungal lanosterol 14α-demethylase using molecular dynamic simulation and docking approaches

Informatics in Medicine Unlocked, 2020
The emergence of resistance to azole drugs, presented significant problems for medicine that could be overcome by advances in antifungal design. We convinced that the crystal structures of fungal and host lanosterol-14α-demethylases in complex with a ...
Hamid Irannejad, Saeed Emami, Hassan Mirzaei, Seyedeh Mahdieh Hashemi   +3 more
doaj   +1 more source

A conserved amino acid residue critical for product and substrate specificity in plant triterpene synthases [PDF]

, 2016
Triterpenes are structurally complex plant natural products with numerous medicinal applications. They are synthesized through an origami-like process that involves cyclization of the linear 30 carbon precursor 2,3-oxidosqualene into different triterpene
Al-Qurainy, Andrew M. Hemmings, Anne Osbourn, Kushiro, Melissa Salmon, Paul E. O’Maille, Rachel E. Melton, Racolta, Ramesha B. Thimmappa, Richard K. Hughes, Robert E. Minto, Wiederstein, Wu   +12 more
core   +1 more source

Mutations in the _SC4MOL_ gene encoding a novel methyl sterol oxidase cause autosomal recessive psoriasisiform dermatitis, microcephaly and developmental delay [PDF]

, 2008
Disorders of cholesterol biosynthesis have clinical manifestations involving skeleton, eyes, neurologic development, and skin. We describe a patient with congenital cataracts, developmental delay, microcephaly, and low serum cholesterol who developed ...
Abbe Vallejo, Gerard Vockley, Jacqueline Hoover, Jushua Michel, Laura Ferris, Lisa Kratz, Miao He, Michael Gibson, Richard Kelley   +8 more
core   +1 more source

The Investigational Drug VT-1129 Is a Highly Potent Inhibitor of Cryptococcus Species CYP51 but Only Weakly Inhibits the Human Enzyme [PDF]

, 2016
Cryptococcosis is a life-threatening disease often associated with HIV infection. Three Cryptococcus species CYP51 enzymes were purified and catalyzed the 14α-demethylation of lanosterol, eburicol, and obtusifoliol.
Garvey, Edward P., Hoekstra, William J., Kelly, Diane E., Kelly, Steven L., Nes, W. David, Parker, Josie E., Price, Claire L., Schotzinger, Robert J., Warrilow, Andrew G. S.   +8 more
core   +1 more source

Does litomosoides sigmodontis synthesize dimethylethanolamine from choline? [PDF]

, 2008
Juvenile female Litomosoides sigmodontis secrete a protein (Juv-p120) highly modified with dimethylethanolamine (DMAE). In an attempt to establish the source of this decoration worms were pulsed with [3H]-choline and [3H]-ethanolamine and the radio ...
Allen, J E, Allen, Judith, Babayan, S A, Harnett, W, Houston, K M   +4 more
core   +2 more sources

Cytotoxic and Antileishmanial Potential of Pilocarpus microphyllus Essential Oil: In Vitro and In Silico Study

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
Jaborandi (Pilocarpus microphyllus) essential oil is obtained by removal and characterization using GC‐MS, revealing γ‐cadinene and trans‐caryophyllene as major constituents. The oil exhibits biological activity, with antifungal action against Candida spp.
Juniel Cruz Silva, Maria Gabriela Araújo Mendes, Paulo Sérgio de Araujo Sousa, Alyne Rodrigues de Araújo Nobre, Michel Muálem de Moraes Alves, Fernando Aécio de Amorim Carvalho, Tatiane Caroline Daboit, José de Sousa Lima Neto, Ygor Victor Ferreira Pinheiro, Ytallo da Costa Sousa, Edymilaís da Silva Sousa, José Delano Barreto Marinho Filho, Ana Jérsia Araújo, Francisco Artur Silva Filho, Sidney Gonçalo de Lima, Leiz Maria Costa Véras   +15 more
wiley   +1 more source

FoxO4 interacts with the sterol regulatory factor SREBP2 and the hypoxia inducible factor HIF2α at the CYP51 promoter

Journal of Lipid Research, 2014
The late steps of cholesterol biosynthesis are oxygen demanding, requiring eleven oxygen molecules per synthesized cholesterol molecule. A key enzymatic reaction, which occurs at the top of the Bloch and Kandutsch-Russell pathways, is the demethylation ...
Jun Zhu, Xiangning Jiang, Farid F. Chehab   +2 more
doaj   +1 more source

Metabolic and pathologic profiles of human LSS deficiency recapitulated in mice.

PLoS Genetics, 2020
Skin lesions, cataracts, and congenital anomalies have been frequently associated with inherited deficiencies in enzymes that synthesize cholesterol. Lanosterol synthase (LSS) converts (S)-2,3-epoxysqualene to lanosterol in the cholesterol biosynthesis ...
Yoichi Wada, Atsuo Kikuchi, Akimune Kaga, Naoki Shimizu, Junya Ito, Ryo Onuma, Fumiyoshi Fujishima, Eriko Totsune, Ryo Sato, Tetsuya Niihori, Matsuyuki Shirota, Ryo Funayama, Kota Sato, Toru Nakazawa, Keiko Nakayama, Yoko Aoki, Setsuya Aiba, Kiyotaka Nakagawa, Shigeo Kure   +18 more
doaj   +1 more source

Genetic engineering and molecular characterization of yeast strain expressing hybrid human-yeast squalene synthase as a tool for anti-cholesterol drug assessment [PDF]

, 2016
AIMS: The main objective of the study is molecular and biological characterization of the human-yeast hybrid squalene synthase (SQS), as a promising target for treatment of hypercholesterolaemia.
Burzynska, Beata, Danikiewicz, Witold, Gora, Monika, Kapur, S., Komaszylo, Joanna, Leszczynska, Agata, Maciejak, Agata, Plochocka, Danuta, Sojka, M., Swiezewska, Ewa, Tułacz, Dorota, Warchol, I., Wysocka-Kapcinska, Monika   +12 more
core   +1 more source