Bioengineering lantibiotics for therapeutic success [PDF]
Frontiers in Microbiology, 2015 Several examples of highly modified antimicrobial peptides have been described. While many such peptides are non-ribosomally synthesized, ribosomally synthesised equivalents are being discovered with increased frequency.
Des eField +6 more
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Synthesis of a Novel Lantibiotic Using Mutacin II Biosynthesis Apparatus [PDF]
Microbiology Spectrum, 2023 Owing to extensive metagenomic studies, we now have access to numerous sequences of novel bacteriocin-like antimicrobial peptides encoded by various cultivable and noncultivable bacteria.
Saswati Biswas
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BMC Genomics, 2010 Background Lantibiotics are lanthionine-containing, post-translationally modified antimicrobial peptides. These peptides have significant, but largely untapped, potential as preservatives and chemotherapeutic agents.
Ross R Paul +4 more
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Structural insights into the substrate binding mechanism of the class I dehydratase MadB [PDF]
Communications BiologyIn the battle against antimicrobial resistance, lantibiotics have emerged as promising new sources for antimicrobial drugs. Their exceptional stability is due to characteristic modifications termed (methyl-)lanthionine rings.
C. Vivien Knospe +6 more
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Structure, Organization, and Expression of the lct Gene for Lacticin 481, a Novel Lantibiotic Produced by Lactococcus lactis [PDF]
, 1993 The structural gene for the lactococcal lantibiotic lacticin 481 (lct) has been identified and cloned using a degenerated 20-mer DNA oligonucleotide based on the amino-terminal 7 amino acid residues of the purified protein.
Desmazeaud, Michel J., +4 more
core +2 more sources
Specificity and Application of the Lantibiotic Protease NisP [PDF]
Frontiers in Microbiology, 2018 Lantibiotics are ribosomally produced and posttranslationally modified peptides containing several lanthionine residues. They exhibit substantial antimicrobial activity against Gram-positive bacteria, including relevant pathogens.
Manuel Montalbán-López +3 more
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Bioengineered Nisin A Derivatives with Enhanced Activity against Both Gram Positive and Gram Negative Pathogens [PDF]
, 2012 peer-reviewedNisin is a bacteriocin widely utilized in more than 50 countries as a safe and natural antibacterial food preservative. It is the most extensively studied bacteriocin, having undergone decades of bioengineering with a view to improving ...
Begley, Maire +7 more
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Insights into the production and evolution of lantibiotics from a computational analysis of peptides associated with the lanthipeptide cyclase domain. [PDF]
R Soc Open SciMaheshwari N +4 more
europepmc +2 more sources
Bovicin HJ50-like lantibiotics, a novel subgroup of lantibiotics featured by an indispensable disulfide bridge. [PDF]
PLoS ONE, 2014 Lantibiotics are ribosomally-synthesized and posttranslationally modified peptides with potent antimicrobial activities. Discovery of novel lantibiotics has been greatly accelerated with the soaring release of genomic information of microorganisms.
Jian Wang +6 more
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Frontiers in Microbiology, 2023 The rapid emergence of microbial multi-resistance against antibiotics has led to intense search for alternatives. One of these alternatives are ribosomally synthesized and post-translationally modified peptides (RiPPs), especially lantibiotics.
C. Vivien Knospe +9 more
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