Results 11 to 20 of about 6,528 (248)
Lantibiotics:biosynthesis, mode of action and applications [PDF]
Natural product reports, 1999 The incorporation of non-canonical amino acids (ncAAs) into ribosomally synthesized and post-translationally modified peptides, e.g., nisin from the Gram-positive bacterium Lactococcus lactis, bears great potential to expand the chemical space of various
Cindy van Kraaij +6 more
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From Membrane Composition to Antimicrobial Strategies: Experimental and Computational Approaches to AMP Design and Selectivity. [PDF]
SmallAntimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Rossetti P +5 more
europepmc +2 more sources
Microbiology and Molecular Biology Reviews, 2015 SUMMARY The dramatic rise in the incidence of antibiotic resistance demands that new therapeutic options will have to be developed. One potentially interesting class of antimicrobials are the modified bacteriocins termed lantibiotics, which are bacterially produced, posttranslationally modified, lanthionine/methyllanthionine-containing ...
Lorraine A, Draper +3 more
openaire +2 more sources
Listeria monocytogenes-Can We Reduce or Eliminate It From Food Commodities? [PDF]
Mol Nutr Food ResListeria monocytogenes is a foodborne pathogen responsible for listeriosis. Traditional control methods include heat treatment, high‐pressure processing, irradiation, and acidification, all aimed at reducing bacterial load in foods. Emerging strategies include gene expression, CRISPR‐Cas9, bacteriophage, competitive exclusion via beneficial microbes ...
d'Ovidio L +5 more
europepmc +2 more sources
Micromachines, 2021 Lanthionine-containing peptides (lantibiotics) have been considered as pharmaceutical candidates for decades, although their clinical application has been restricted.
Irina Panina +3 more
doaj +1 more source
Engineering of Nisin as a Means for Improvement of Its Pharmacological Properties: A Review
Pharmaceuticals, 2023 Lantibiotics are believed to have a conceivable potential to be used as therapeutics, especially against clinically resistant bacterial strains. However, their low solubility and poor stability under physiological conditions limit their availability for ...
Mateusz Musiejuk, Paweł Kafarski
doaj +1 more source
Microorganisms, 2022 Anatomical and physiological considerations indicate that the oral cavity is a primary source of the lung microbiota community, and recent studies have shown that the microbiota in the lungs contributes to immunological homeostasis, potentially altering ...
Francesco Di Pierro +6 more
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Frontiers in Microbiology, 2020 Due to the rapid emergence of multi-resistant bacterial strains in recent decades, the commercially available effective antibiotics are becoming increasingly limited.
Hamid Reza Karbalaei-Heidari +3 more
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Microorganisms, 2021 Post-translationally modified, (methyl-)lanthionine-containing peptides are produced by several Gram-positive bacteria. These so-called lantibiotics have potent activity against various bacterial pathogens including multidrug-resistant strains and are ...
Oliver Goldbeck +3 more
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Frontiers in Microbiology, 2020 Coupling functional moieties to lantibiotics offers exciting opportunities to produce novel derivatives with desirable properties enabling new functions and applications.
Jingjing Deng +6 more
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