Results 41 to 50 of about 16,901 (224)

Enhanced methods for unbiased deep sequencing of Lassa and Ebola RNA viruses from clinical and biological samples [PDF]

, 2015
We have developed a robust RNA sequencing method for generating complete de novo assemblies with intra-host variant calls of Lassa and Ebola virus genomes in clinical and biological samples.
Andersen, Kristian G, Berlin, Aaron, Birren, Bruce W, Busby, Michele, Ehiane, Philomena E, England, Eleina, Folarin, Onikepe, Garry, Robert F, Gire, Stephen K, Gladden, Adrianne D, Gnirke, Andreas, Goba, Augustine, Grant, Donald S, Happi, Christian, Hensley, Lisa, Honko, Anna, Kahn, S Humarr, Levin, Joshua Z, Malboeuf, Christine M, Matranga, Christian B, Mikkelsen, Tarjei S, Moses, Lina M, Odia, Ikponmwonsa, Sabeti, Pardis C, Stremlau, Matthew, Tewhey, Ryan, Winnicki, Sarah   +26 more
core   +1 more source

Genetic Diversity among Lassa Virus Strains [PDF]

Journal of Virology, 2000
ABSTRACT The arenavirus Lassa virus causes Lassa fever, a viral hemorrhagic fever that is endemic in the countries of Nigeria, Sierra Leone, Liberia, and Guinea and perhaps elsewhere in West Africa. To determine the degree of genetic diversity among Lassa virus strains, partial nucleoprotein (NP) gene sequences were obtained from 54 strains ...
M D, Bowen, P E, Rollin, T G, Ksiazek, H L, Hustad, D G, Bausch, A H, Demby, M D, Bajani, C J, Peters, S T, Nichol   +8 more
openaire   +2 more sources

Molecular confirmation of Lassa fever imported into Ghana

African Journal of Laboratory Medicine, 2016
Background: Recent reports have shown an expansion of Lassa virus from the area where it was first isolated in Nigeria to other areas of West Africa.
Joseph H.K. Bonney, Edward O. Nyarko, Sally-Ann Ohene, Joseph Amankwa, Ralph K. Ametepi, Shirley C. Nimo-Paintsil, Badu Sarkodie, Prince Agbenohevi, Michael Adjabeng, Nicholas N.A. Kyei, Samuel Bel-Nono, William K. Ampofo   +11 more
doaj   +1 more source

Diversity in responses to oncolytic Lassa-vesicular stomatitis virus in patient-derived glioblastoma cells

Molecular Therapy: Oncolytics, 2021
The difficulty of glioblastoma treatment makes it a good candidate for novel therapies, such as oncolytic viruses. Vesicular stomatitis virus expressing Lassa virus glycoprotein (Lassa-VSV) showed significant promise in animal models using established ...
Teddy E. Kim, Shelby Puckett, Kailong Zhang, Denise M. Herpai, David A. Ornelles, John N. Davis, Anthony N. van den Pol, Waldemar Debinski, Douglas S. Lyles   +8 more
doaj   +1 more source

Human platelets and their capacity of binding viruses: Meaning and challenges? [PDF]

, 2015
Blood platelets are first aimed at ensuring primary hemostasis. Beyond this role, they have been acknowledged as having functions in the maintenance of the vascular arborescence and, more recently, as being also innate immune cells, devoted notably to ...
Chabert, Adrien, Cognasse, Fabrice, Garraud, Olivier, Gomez, Ricardo Martin, Hamzeh Cognasse, Hind, Pozzetto, Bruno, Schattner, Mirta Ana   +6 more
core   +2 more sources

Phylogeography of Lassa Virus in Nigeria [PDF]

Journal of Virology, 2019
Lassa virus is the causative agent of Lassa fever, a viral hemorrhagic fever with a case fatality rate of approximately 30% in Africa. Previous studies disclosed a geographical pattern in the distribution of Lassa virus strains and a westward movement of the virus across West Africa during evolution.
Ehichioya, Deborah U., Dellicour, Simon, Pahlmann, Meike, Rieger, Toni, Oestereich, Lisa, Becker-Ziaja, Beate, Cadar, Daniel, Ighodalo, Yemisi, Olokor, Thomas, Omomoh, Emmanuel, Oyakhilome, Jennifer, Omiunu, Racheal, Agbukor, Jacqueline, Ebo, Benevolence, Aiyepada, John, Ebhodaghe, Paulson, Osiemi, Blessing, Ehikhametalor, Solomon, Akhilomen, Patience, Airende, Michael, Esumeh, Rita, Muoebonam, Ekene, Giwa, Rosemary, Ekanem, Anieno, Igenegbale, Ganiyu, Odigie, George, Okonofua, Grace, Enigbe, Racheal, Yerumoh, Edna Omonegho, Pallasch, Elisa, Bockholt, Sabrina, Kafetzopoulou, Liana E., Duraffour, Sophie, Okokhere, Peter O., Akpede, George O., Okogbenin, Sylvanus A., Odia, Ikponmwosa, Aire, Chris, Akpede, Nosa, Tobin, Ekaete, Ogbaini-Emovon, Ephraim, Lemey, Philippe, Adomeh, Donatus, Asogun, Danny A., Guenther, Stephan   +44 more
openaire   +4 more sources

New Hosts of The Lassa Virus [PDF]

Scientific Reports, 2016
Abstract Lassa virus (LASV) causes a deadly haemorrhagic fever in humans, killing several thousand people in West Africa annually. For 40 years, the Natal multimammate rat, Mastomys natalensis , has been assumed to be the sole host of LASV.
Olayemi, Ayodeji, Cadar, Daniel, Magassouba, N. Faly, Obadare, Adeoba, Kourouma, Fode, Oyeyiola, Akinlabi, Fasogbon, Samuel, Igbokwe, Joseph, Rieger, Toni, Bockholt, Sabrina, Jerome, Hanna, Schmidt-Chanasit, Jonas, Garigliany, Mutien-Marie, Lorenzen, Stephan, Igbahenah, Felix, Fichet, Jean-Nicolas, Ortsega, Daniel, Omilabu, Sunday, Gunther, Stephan, Fichet-Calvet, Elisabeth   +19 more
openaire   +3 more sources

Bayesian estimation of Lassa virus epidemiological parameters: Implications for spillover prevention using wildlife vaccination.

PLoS Neglected Tropical Diseases, 2020
Lassa virus is a significant burden on human health throughout its endemic region in West Africa, with most human infections the result of spillover from the primary rodent reservoir of the virus, the natal multimammate mouse, M. natalensis.
Scott L Nuismer, Christopher H Remien, Andrew J Basinski, Tanner Varrelman, Nathan Layman, Kyle Rosenke, Brian Bird, Michael Jarvis, Peter Barry, Patrick W Hanley, Elisabeth Fichet-Calvet   +10 more
doaj   +1 more source

Immunogenesis in Lassa fever and prospects for vaccine development

Журнал микробиологии, эпидемиологии и иммунобиологии, 2023
Analysis of literature data on the structure of the Lassa virus genome and its strain diversity has shown that the molecular heterogeneity of strains is essential in the design of vaccines and evaluation of their efficacy, which is determined by the ...
Vladimir A. Markin
doaj   +1 more source

The role of the gut microbiome in the regulation of high‐altitude adaptation

iMeta, EarlyView.
This study is the first to elucidate mechanisms of high‐altitude adaptation from the perspective of the rumen ecosystem by using indigenous yaks and Holstein cows that have lived at high altitude since birth as comparative models. Through a systematic comparison of their rumen ecology using multi‐omics approaches—including rumen metagenomics ...
Xinyu Zhang, Senlin Zhu, Michael Kreuzer, Shoukun Ji, Wei Wang, Yanliang Bi, Shengli Li   +6 more
wiley   +1 more source