Results 61 to 70 of about 16,901 (224)

The Current Landscape and Future Prospects of Vaccine Manufacturing in Africa: Challenges, Innovations, and Opportunities: A Narrative Review

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background and Aims Africa has significant challenges in meeting its vaccination needs, including inadequate manufacturing capacity, infrastructure deficiencies, a scarcity of experienced personnel, regulatory hurdles, restricted access to technology and intellectual property.
Courage Chandipwisa, Agness Shimilimo, Olivier Uwishema, Helen Onyeaka   +3 more
wiley   +1 more source

Mapping of the Lassa virus LAMP1 binding site reveals unique determinants not shared by other old world arenaviruses.

PLoS Pathogens, 2017
Cell entry of many enveloped viruses occurs by engagement with cellular receptors, followed by internalization into endocytic compartments and pH-induced membrane fusion.
Hadar Israeli, Hadas Cohen-Dvashi, Anastasiya Shulman, Amir Shimon, Ron Diskin   +4 more
doaj   +1 more source

Lassa Virus in Pygmy Mice, Benin, 2016–2017

Emerging Infectious Diseases, 2019
Lassa virus has been identified in 3 pygmy mice, Mus baoulei, in central Benin. The glycoprotein and nucleoprotein sequences cluster with the Togo strain. These mice may be a new reservoir for Lassa virus in Ghana, Togo, and Benin.
Anges Yadouleton, Achaz Agolinou, Fodé Kourouma, Raoul Saizonou, Meike Pahlmann, Sonia Kossou Bedié, Honoré Bankolé, Beate Becker-Ziaja, Fernand Gbaguidi, Anke Thielebein, N’Faly Magassouba, Sophie Duraffour, Jean-Pierre Baptiste, Stephan Günther, Elisabeth Fichet-Calvet   +14 more
doaj   +1 more source

Comparative Genomic Characterization of the Multimammate Mouse Mastomys coucha. [PDF]

, 2019
Mastomys are the most widespread African rodent and carriers of various diseases such as the plague or Lassa virus. In addition, mastomys have rapidly gained a large number of mammary glands.
Aaron Hardin, Andersen, Bao, Besemer, Bickhart, Blanchette, Bolger, Bonwitt, Booker, Bourque, Camacho, Capra, Chapman, Chen, Chikhi, Chu, Colangelo, Dewey, Dierckxsens, Eblaghie, Grabherr, Hayssen, Heinz, Helfrich, Holloway, Holt, Jiang, Kannan, Kiełbasa, Kim, Kimberly A Nevonen, Kolmogorov, Korf, Krueger, Lecompte, Li, Li, Lok, Lowe, Lucia Carbone, MacManes, McLean, Modlin, Nadav Ahituv, Nagy, Nilsson, Närhi, Pennacchio, Pertea, Pimentel, Pollard, Sands, Schep, Scott, Siepel, Siepel, Simão, Smit, Snell, Song, Stanke, UniProt Consortium, Van der Auwera, Veltmaat, Veltmaat, Walter L Eckalbar   +65 more
core   +1 more source

Sex Differences in Response to Viral Vector Vaccines—Implications for Future Vaccine Design

Immunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT Vaccination represents one of the most impactful public health achievements, preventing 3.5 to 5 million deaths annually according to estimates of the World Health Organization. Yet, recent outbreaks of emerging and reemerging infectious diseases highlight the need for rapid and strategic vaccine development using vaccine platforms ...
Ilka Grewe, Tamara Zoran, Marylyn Martina Addo   +2 more
wiley   +1 more source

Improving the Breadth of the Host’s Immune Response to Lassa Virus

Pathogens, 2018
In 2017, the global Coalition for Epidemic Preparedness (CEPI) declared Lassa virus disease to be one of the world’s foremost biothreats. In January 2018, World Health Organization experts met to address the Lassa biothreat.
Juan Carlos Zapata, Sandra Medina-Moreno, Camila Guzmán-Cardozo, Maria S. Salvato   +3 more
doaj   +1 more source

Using modelling to disentangle the relative contributions of zoonotic and anthroponotic transmission: the case of lassa fever. [PDF]

, 2015
BACKGROUND: Zoonotic infections, which transmit from animals to humans, form the majority of new human pathogens. Following zoonotic transmission, the pathogen may already have, or may acquire, the ability to transmit from human to human. With infections
Cunningham, Andrew A, Fichet-Calvet, Elisabeth, Garry, Robert F, Grant, Donald S, Khan, Sheik Humarr, Leach, Melissa, Lo Iacono, Giovanni, Moses, Lina M, Schieffelin, John S, Shaffer, Jeffrey G, Webb, Colleen T, Wood, James LN   +11 more
core   +4 more sources

A novel single‐cell NAD‐ME C4 subtype integrated with CAM and bicarbonate use in an aquatic plant

New Phytologist, Volume 249, Issue 5, Page 2386-2401, March 2026.
Summary Many plants maximize photosynthesis by using a CO2‐concentrating mechanism (CCM). Based on physiology, the freshwater plant Ottelia alismoides has three CCMs: C4 metabolism (NAD‐malic enzyme (NAD‐ME) subtype) and bicarbonate‐use during the day plus crassulacean acid metabolism (CAM) at night and lacks Kranz anatomy. Here, we combined a range of
Hong Sheng Jiang, Wenmin Huang, Shijuan Han, Pengpeng Li, Zuying Liao, Liyuan Wei, Lei Zhao, Shuping Gu, Jun Ding, Brigitte Gontero, Stephen C. Maberly, Wei Li   +11 more
wiley   +1 more source

Treatment of Marburg and Ebola hemorrhagic fevers: A strategy for testing new drugs and vaccines under outbreak conditions. [PDF]

, 2008
The filoviruses, Marburg and Ebola, have the dubious distinction of being associated with some of the highest case-fatality rates of any known infectious disease-approaching 90% in many outbreaks.
A.G. Sprecher, Anon., Baize, Basler, Bausch, Bausch, Bausch, Bausch, Bausch, Bausch, Bausch, Bausch, Benjamin Jeffs, Bernard, Borchert, Bosio, Bosio, Boumandouki, Bray, Bray, Bray, Bray, Brummel-Ziedins, Bukreyev, Bwaka, CDC and WHO, Colebunders, Daddario-DiCaprio, Daniel G. Bausch, Dowell, Egbring, Emond, Enterlein, Feldmann, Formenty, Fourrier, Gear, Geisbert, Geisbert, Geisbert, Geisbert, Geisbert, Geisbert, Geisbert, Geisbert, Gibbs, Gupta, Hensley, Hensley, Hensley, Hewlett, Hewlett, Hoenen, Hotchkiss, Huggins, Jahrling, Jahrling, Jahrling, Jeffs, Johnson, Jones, Jones, Khan, Ksiazek, Kudoyarova-Zubavichene, Larkin, Leroy, Leroy, Mahanty, Mahanty, Martin, Martini, Martini, Monath, Mupapa, Mupapa, Nikiforov, Oswald, Parrino, Pattyn, Paul Boumandouki, Peters, Peterson, Peterson, Pourrut, Reid, Rivers, Roberts, Rollin, Sanchez, Schnittler, Schuler, Smith, Spurgers, Stille, Sullivan, Sullivan, Swanepoel, Takada, Todorovitch, Towner, Warfield, Warfield, Warfield, Wilson, Zaki   +105 more
core   +2 more sources

Domain Structure of Lassa Virus L Protein [PDF]

Journal of Virology, 2011
ABSTRACT The 200-kDa L protein of arenaviruses plays a central role in viral genome replication and transcription. This study aimed at providing evidence for the domain structure of L protein by combining bioinformatics with a stepwise mutagenesis approach using the Lassa virus minireplicon system.
Linda, Brunotte, Michaela, Lelke, Meike, Hass, Katja, Kleinsteuber, Beate, Becker-Ziaja, Stephan, Günther   +5 more
openaire   +2 more sources