Results 71 to 80 of about 16,901 (224)

Lassa Virus Infection: a Summary for Clinicians

International Journal of Infectious Diseases, 2022
This summary on Lassa virus (LASV) infection and Lassa fever disease (LF) was developed from a clinical perspective to provide clinicians with a condensed, accessible understanding of the current literature. The information provided highlights pathogenesis, clinical features, and diagnostics emphasizing therapies and vaccines that have demonstrated ...
Vanessa Raabe, Aneesh K Mehta, Jared D. Evans, Adam Beitscher, Nahid Bhadelia, David Brett-Major, Theodore J Cieslak, Richard T Davey, Jared D Evans, Maria G Frank, Peter Iwen, Mark G Kortepeter, Corri Levine, Susan McLellan, Aneesh K Mehta, Lauren Sauer, Erica S Shenoy, Kimon Zachary   +17 more
openaire   +3 more sources

ZNRD2 Mediated Nucleoprotein Aggregation Impairs Respiratory Syncytial Virus Replication

Advanced Science, Volume 13, Issue 12, 27 February 2026.
During RSV infection, nucleoprotein (N) forms RNA‐bound oligomers. The host protein ZNRD2 binds to these oligomers, promoting their transition into insoluble aggregates. These aggregates simultaneously sequester functional N to restrict viral production and disrupt chaperonin assembly quality control by interfering with ZNRD2's role as an adaptor ...
Haiwu Zhou, Mingbin He, Jinhong Du, Cong Liu, Weiwei Wang, Yuewen Han, Zhifei Li, Yali Qin, Mingzhou Chen   +8 more
wiley   +1 more source

New Lineage of Lassa Virus, Togo, 2016

Emerging Infectious Diseases, 2018
We describe a strain of Lassa virus representing a putative new lineage that was isolated from a cluster of human infections with an epidemiologic link to Togo. This finding extends the known range of Lassa virus to Togo.
Shannon L.M. Whitmer, Thomas Strecker, Daniel Cadar, Hans-Peter Dienes, Kelly Faber, Ketan Patel, Shelley M. Brown, William G. Davis, John D. Klena, Pierre E. Rollin, Jonas Schmidt-Chanasit, Elisabeth Fichet-Calvet, Bernd Noack, Petra Emmerich, Toni Rieger, Svenja Wolff, Sarah Katharina Fehling, Markus Eickmann, Jan Philipp Mengel, Tilman Schultze, Torsten Hain, William Ampofo, Kofi Bonney, Juliana Naa Dedei Aryeequaye, Bruce Ribner, Jay B. Varkey, Aneesh K. Mehta, G. Marshall Lyon, Gerrit Kann, Philipp De Leuw, Gundolf Schuettfort, Christoph Stephan, Ulrike Wieland, Jochen W.U. Fries, Matthias Kochanek, Colleen S. Kraft, Timo Wolf, Stuart T. Nichol, Stephan Becker, Ute Ströher, Stephan Günther   +40 more
doaj   +1 more source

Systematics, Ecology, and Host Switching: Attributes Affecting Emergence of the Lassa Virus in Rodents across Western Africa

Viruses, 2020
Ever since it was established that rodents serve as reservoirs of the zoonotic Lassa virus (LASV), scientists have sought to answer the questions: which populations of rodents carry the virus?
Ayodeji Olayemi, Elisabeth Fichet-Calvet
doaj   +1 more source

Review of candidate vaccines for the prevention of Lassa fever

Вопросы вирусологии, 2021
The Lassa virus one of the main etiological agent of hemorrhagic fevers in the world: according to WHO estimates, it affects 100,000 to 300,000 people annually, which results in up to 10,000 deaths [1].
O. D. Popova, O. V. Zubkova, T. A. Ozharovskaia, D. I. Zrelkin, D. V. Voronina, I. V. Dolzhikova, D. V. Shcheblyakov, B. S. Naroditsky, D. Yu. Logunov, A. L. Gintsburg   +9 more
doaj   +1 more source

Cellular Factors Required for Lassa Virus Budding [PDF]

Journal of Virology, 2006
ABSTRACT It is known that Lassa virus Z protein is sufficient for the release of virus-like particles (VLPs) and that it has two L domains, PTAP and PPPY, in its C terminus. However, little is known about the cellular factor for Lassa virus budding. We examined which cellular factors are used in Lassa virus Z budding.
Shuzo, Urata, Takeshi, Noda, Yoshihiro, Kawaoka, Hideyoshi, Yokosawa, Jiro, Yasuda   +4 more
openaire   +2 more sources

Land use gradients drive spatial variation in Lassa fever host communities in the Eastern Province of Sierra Leone

Journal of Animal Ecology, Volume 95, Issue 2, Page 296-312, February 2026.
As West Africa urbanises, the risk of Lassa fever may paradoxically decrease. We found the invasive house mouse, a dominant urban species, outcompetes and displaces the primary Lassa virus host. Considering these species interactions is critical for accurately predicting future zoonotic disease patterns.
David Simons, Rory Gibb, Umaru Bangura, Dianah Sondufu, Joyce Lamin, James Koninga, Momoh Foday, Mike Dawson, Joseph Lahai, Rashid Ansumana, Elisabeth Fichet‐Calvet, Deborah Watson‐Jones, Richard Kock, Kate E. Jones   +13 more
wiley   +1 more source

Detection of Antibody and Antigen for Lassa Virus Nucleoprotein in Monkeys from Southern Nigeria

Journal of Epidemiology and Global Health, 2019
Lassa fever is a deadly viral haemorrhagic fever caused by Lassa Virus (LASV). Rodents, especially, Mystomys natalensis, are the known reservoirs of LASV and humans are the defined hosts.
Bamidele Nyemike Ogunro, Babasola Oluseyi Olugasa, Adeyemi Kayode, Olayinka Olabisi Ishola, Oluseyi Noah Kolawole, Eugene Amiewanlen Odigie, Christian Happi   +6 more
doaj   +1 more source

High crossreactivity of human T cell responses between Lassa virus lineages.

PLoS Pathogens, 2020
Lassa virus infects hundreds of thousands of people each year across rural West Africa, resulting in a high number of cases of Lassa fever (LF), a febrile disease associated with high morbidity and significant mortality.
Brian M Sullivan, Saori Sakabe, Jessica N Hartnett, Nhi Ngo, Augustine Goba, Mambu Momoh, John Demby Sandi, Lansana Kanneh, Beatrice Cubitt, Selma D Garcia, Brian C Ware, Dylan Kotliar, Refugio Robles-Sikisaka, Karthik Gangavarapu, Luis Branco, Philomena Eromon, Ikponmwosa Odia, Ephraim Ogbaini-Emovon, Onikepe Folarin, Sylvanus Okogbenin, Peter O Okokhere, Christian Happi, Juan Carlos de la Torre, Pardis C Sabeti, Kristian G Andersen, Robert F Garry, Donald S Grant, John S Schieffelin, Michael B A Oldstone   +28 more
doaj   +1 more source

Ebola virus disease epidemic in West Africa: Lessons learned and issues arising from West African countries [PDF]

, 2015
© Royal College of Physicians 2015. All rights reserved.The current Ebola virus disease (EVD) outbreak ravaging three nations in West Africa has affected more than 14,000 persons and killed over 5,000.
Akpalu, AK, Foster, M, Ka, MM, McConnochie, M, Oleribe, OO, Salako, BL, Taylor-Robinson, SD   +6 more
core   +1 more source