Results 151 to 160 of about 672,964 (288)
Extended defects in curved spacetimes [PDF]
, 1999 This Thesis is concerned with three particular aspects of extended cosmic strings and domain walls in cosmology: their dynamics, gravitation and interaction with a black hole. In Chapter 3, we study the dynamics of an abelian-Higgs cosmic string. We find
Bonjour, F., Bonjour, Filipe
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Fundamental magnetic properties of Greigite (Fe3S4) [PDF]
, 2009 Over the last twenty years, greigite (Fe3S4), an authigenic magnetic iron sulphide mineral, has been increasingly identified in sulphate-reducing marine and lacustrine sedimentary systems.
Chang, Liao
core
SNARE mimicry by the CD225 domain of IFITM3 enables regulation of homotypic late endosome fusion
The EMBO JournalThe CD225/Dispanin superfamily contains membrane proteins that regulate vesicular transport and membrane fusion events required for neurotransmission, glucose transport, and antiviral immunity.
Kazi Rahman +5 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Early Media Effects Theory & the Suggestion Doctrine [PDF]
While much has been written on the history of media effects research in the United States, a casual review of the literature could reasonably lead one to believe that little if any such work was conducted until the 1940s.
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
PYRE insertion within HIV-1 subtype C p6-Gag functions as an ALIX-dependent late domain. [PDF]
Sci Rep, 2018 Chaturbhuj D, Patil A, Gangakhedkar R.
europepmc +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Redundant Late Domain Functions of Tandem VP2 YPX<sub>3</sub>L Motifs in Nonlytic Cellular Egress of Quasi-enveloped Hepatitis A Virus. [PDF]
J Virol, 2018 González-López O +8 more
europepmc +1 more source