Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
South Bohemian sacral architecture of the late Gothic 1450 - 1550 in the Rosenberg domain [PDF]
, 2012 South Bohemian sacral architecture of the late Gothic1450 - 1550 in the Rosenberg domain Mgr. Roman Lavička A group of late-Gothic churches, which keeps attracting our attention, was built in the Rosenberg domain during the reign of the Jagiellon dynasty.
Lavička, Roman
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Shifting expectations: when knowledge-based predictions and linguistic context collide
Frontiers in Language SciencesTo cope with the demands of language comprehension, young adults often actively engage in prediction of upcoming information—which may be more or less successful depending on each individual's specific knowledge.
Melissa Troyer +3 more
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
South Bohemian sacral architecture of the late Gothic 1450 - 1550 in the Rosenberg domain [PDF]
, 2014 South Bohemian sacral architecture of the late Gothic1450 - 1550 in the Rosenberg domain Mgr. Roman Lavička A group of late-Gothic churches, which keeps attracting our attention, was built in the Rosenberg domain during the reign of the Jagiellon dynasty.
Lavička, Roman
core
The Late Domain of Prototype Foamy Virus Gag Facilitates Autophagic Clearance of Stress Granules by Promoting Amphisome Formation. [PDF]
J Virol, 2020 Zheng Y +8 more
europepmc +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Perbandingan Metode Penyelesaian Permasalahan Optimasi Lintas Domain dengan Pendekatan Hyper-heuristic Menggunakan Algoritma Reinforcement Learning-Late Acceptance [PDF]
, 2019 Sebuah organisasi terkadang membutuhkan solusi untuk permasalahan optimasi lintas domain. Permasalahan optimasi lintas domain merupakan permasalahan yang memiliki karakteristik berbeda, misalnya antar domain optimasi penjadwalan, rute kendaraan, bin ...
Firdaus, Anang
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