Results 121 to 130 of about 1,753,266 (286)

Deletion of a Cys–His motif from the Alpharetrovirus nucleocapsid domain reveals late domain mutant-like budding defects

Virology, 2006
The Rous sarcoma virus (RSV) Gag polyprotein is the only protein required for virus assembly and release. We previously found that deletion of either one of the two Cys-His (CH) motifs in the RSV nucleocapsid (NC) protein did not abrogate Gag-Gag interactions, RNA binding, or packaging but greatly reduced virus production (E-G. Lee, A.
Lee, Eun-Gyung, Linial, Maxine L.
openaire   +2 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Self-organization of (001) cubic crystal surfaces

, 2001
Self-organization on crystal surface is studied as a two dimensional spinodal decomposition in presence of a surface stress. The elastic Green function is calculated for a $(001)$ cubic crystal surface taking into account the crystal anisotropy ...
A. G. Khachaturyan, A. Karma, A. Zangwill, C. Wagner, F.M. Leibsle, H. Ellmer, H.E. Cook, I.M. Lifshitz, J. Tersoff, J. Villain, K. Kassner, Klaus Kern, Kwok-On Ng, L.Q. Chen, Laurent Proville, M. Pinczolits, M. Sotto, O.L. Alerhand, S. Narasimhan, S. Song, T.W. Fishlock, V. Repain, V.I. Marchenko   +22 more
core   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

The neural signature of self-concept development in adolescence: The role of domain and valence distinctions

Developmental Cognitive Neuroscience, 2018
Neuroimaging studies in adults showed that cortical midline regions including medial prefrontal cortex (mPFC) and posterior parietal cortex (PPC) are important in self-evaluations.
R. van der Cruijsen, S. Peters, L.P.E. van der Aar, E.A. Crone   +3 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Late Quaternary climate variability in the Indian monsoon domain

, 2015
Der Indische Subkontinent ist charakterisiert durch eine Vielzahl an Klimazonen, welche von alpinem Klima im Himalaya über tropisches Klima in Zentralindien bis zu ariden Regionen in NW-Indien reichen. Eine Vielzahl an Niederschlagsregimes (der SW- und NO-Monsun sowie die winterliche Westwinddrift) und glaziale Schmelzwasser tragen zum regionalen ...
openaire   +4 more sources

Late-time entropy production due to the decay of domain walls

Physics Letters B, 2005
It is shown that late-time decay of domain walls can dilute unwanted relics such as moduli, if the universe was dominated by frustrated domain walls with tension $ = (1 - 100 TeV)^3$. Since energy density of the frustrated domain walls decreases as slow as the inverse of the scale factor, an overclosure limit on the axion decay constant $f_a$ is also ...
Kawasaki, Masahiro, Takahashi, Fuminobu
openaire   +2 more sources