Results 111 to 120 of about 1,753,266 (286)

Anti-bis(monoacylglycero)phosphate antibody accumulates acetylated LDL-derived cholesterol in cultured macrophages

Journal of Lipid Research, 2007
Bis(monoacylglycero)phosphate (BMP), also called lysobisphosphatidic acid, is a phospholipid highly enriched in the internal membranes of multivesicular late endosomes, in which it forms specialized lipid domains.
Isabelle Delton-Vandenbroucke, Jerome Bouvier, Asami Makino, Nelly Besson, Jean-François Pageaux, Michel Lagarde, Toshihide Kobayashi   +6 more
doaj   +1 more source

Time Evolution of Temperature and Entropy of Various Collapsing Domain Walls

, 2012
We investigate the time evolution of the temperature and entropy of gravitationally collapsing domain walls as seen by an asymptotic observer. In particular, we seek to understand how topology and the addition of a cosmological constant affect the ...
E. Greenwood, E. Greenwood, E. Greenwood, Evan Halstead, H. Goldstein, I. Arraut, J.L. Said   +6 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Spreading of Block Copolymer Films and Domain Alignment at Moving Terrace Steps

, 2003
We investigate spreading of phase separated copolymer films, where domain walls and thickness steps influence polymer flow. We show that at early stages of spreading its rate is determined by slow activated flow at terrace steps (i.e.
de Gennes P. G., Semenov A. N., Thomas A. Witten, Turner M. S., Vladimir A. Belyi   +4 more
core   +1 more source

Functional domains of the 50S subunit mature late in the assembly process

Nucleic Acids Research, 2013
AbstractDespite the identification of many factors that facilitate ribosome assembly, the molecular mechanisms by which they drive ribosome biogenesis are poorly understood. Here, we analyze the late stages of assembly of the 50S subunit using Bacillus subtilis cells depleted of RbgA, a highly conserved GTPase.
Jomaa, Ahmad, Jain, Nikhil, Davis, Joseph H., Williamson, James R., Britton, Robert A., Ortega, Joaquin   +5 more
openaire   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

BIOSTRATIGRAPHIC STUDY OF THE ILAM AND GURPI FORMATIONS BASED ON PLANKTONIC FORAMINIFERA IN SE OF SHIRAZ, IRAN [PDF]

Journal of Sciences, Islamic Republic of Iran, 2002
The study of planktonic foraminifera of the Ilam and Gurpi formations at Sarvestan area (SE of Shiraz) enables me to find the most standard biozones defined in mediterranean regions, especially Tethysian domain. Seven biozones were determined. Biozones I
doaj  

Non-Abelian Vortices in Supersymmetric Gauge Field Theory via Direct Methods

, 2011
Vortices in supersymmetric gauge field theory are important constructs in a basic conceptual phenomenon commonly referred to as the dual Meissner effect which is responsible for color confinement.
A. Actor, A. Gorsky, A. Gustavsson, A. Hanany, A. Hanany, A. Hanany, A. Jaffe, A. Marshakov, A.A. Abrikosov, A.M. Polyakov, A.S. Kronfeld, C.H. Taubes, C.H. Taubes, C.S. Lin, C.S. Lin, E.B. Bogomol’nyi, Elliott H. Lieb, G. Dunne, G. Dunne, G. ’t Hooft, G. ’t Hooft, G. ’t Hooft, G. ’t Hooft, H.B. Nielsen, J. Gomis, J. Greensite, J. Hong, K. Konishi, L. Del Debbio, L. Fontana, M. Benna, M. Eto, M. Eto, M. Eto, M. Eto, M. Noguchi, M. Shifman, M. Shifman, M. Shifman, M. Shifman, M. Shifman, M.K. Prasad, O. Aharony, P. Goddard, P.A. Horvathy, R. Auzzi, R. Auzzi, R. Jackiw, S. Gustafson, S. Mandelstam, S. Mandelstam, S. Terashima, S. Wang, S.B. Gudnason, T. Aubin, T. Suyama, T. Suzuki, Y. Nambu, Y. Yang, Yisong Yang   +59 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source