Results 141 to 150 of about 4,141,686 (289)

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Identifying modifiable factors and their joint associations on late-onset schizophrenia risk in the UK Biobank: a prospective exposure-wide association study

BMJ Mental Health
Background One in four cases of schizophrenia begins in late life, resulting in high unemployment and reduced life expectancy. However, knowledge of the modifiable risk factors for late-onset schizophrenia and their combined effects is limited.Aims To ...
Haibo Wang, Lei Xu, Fan Jiang, Shanquan Chen, Emilio Fernandez-Egea, Xinyu Li, Wenbo Song, Alimu Dayimu, Qiuyue Dong, Rudolf N. Cardinal, Huizhi Liang   +10 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Experiments on domain adaptation for English-Hindi SMT [PDF]

, 2009
Statistical Machine Translation (SMT) systems are usually trained on large amounts of bilingual text and monolingual target language text. If a significant amount of out-of-domain data is added to the training data, the quality of translation can drop ...
Way, Andy, Naskar, Sudip Kumar, van Genabith, Josef, Haque, Rejwanul   +3 more
core   +2 more sources

Age predominates as associate than reproductive health stage for 5 min heart rate variability in middle aged women- a cross-sectional study from Gujarat, India

Journal of Family Medicine and Primary Care
Introduction: Cardiovascular health is adversely affected by menopausal transition with reduced heart rate variability (HRV) as a manifest. Electrocardiogram (ECG) based 5 min HRV has worsening trend from premenopausal to postmenopausal stage, but age is
Jayesh Dalpatbhai Solanki, Divyang Rajeshkumar Joshi, Krina Ashish Atodaria, Chhaya Maheshbhai Ghodadara   +3 more
doaj   +1 more source

Late modern English: novel encounters/ edited by Merja Kytö, Erik Smitterberg.

, 2020
Includes bibliographical references and index."The past few decades have witnessed an unprecedented surge of interest in the language of the Late Modern English period.
Kytö Merja, Smitterberg Erik
core  

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Studies in Late Antiquity

Studies in Late Antiquity (SLA) is a forum for innovation and reflection on global Late Antiquity (150 - 750 CE) which questions and expands on received models and methods. Primary points of interest include interconnections between the Mediterranean and
Roberta Mazza
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source