Results 61 to 70 of about 4,141,686 (289)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The Conserved YPX₃L Motif in the BK Polyomavirus VP1 Protein Is Important for Viral Particle Assembly but Not for Its Secretion into Extracellular Vesicles

Viruses
The BK polyomavirus (BKPyV) is a small DNA non-enveloped virus whose infection is asymptomatic in most of the world’s adult population. However, in cases of immunosuppression, the reactivation of the virus can cause various complications, and in ...
Marine Bentz, Louison Collet, Virginie Morel, Véronique Descamps, Emmanuelle Blanchard, Caroline Lambert, Baptiste Demey, Etienne Brochot, Francois Helle   +8 more
doaj   +1 more source

Overexpression of the N-terminal domain of TSG101 inhibits HIV-1 budding by blocking late domain function [PDF]

Proceedings of the National Academy of Sciences, 2002
Efficient budding of HIV-1 from the plasma membrane of infected cells requires the function of a 6-kDa protein known as p6. A highly conserved Pro-Thr-Ala-Pro (PTAP) motif (the “late” or “L” domain), is critical for the virus-budding activity of p6. Recently, it was demonstrated that the product of tumor susceptibility gene 101 (TSG101), which contains
Dimiter G, Demirov, Akira, Ono, Jan M, Orenstein, Eric O, Freed   +3 more
openaire   +2 more sources

Historical Reasoning: The Interplay of Domain-Specific and Domain-General Aspects

, 2018
In this chapter, we explore the question of domain-general and domain-specific aspects of reasoning in history. Historical reasoning is a form of informal reasoning. There are no single procedures to reach a conclusion and there is no single clear-cut or
van Drie, J., Osborne, J., Engelmann, K., Fischer, F., Chinn, C.A., van Boxtel, C.   +5 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

On Comparing Planning Domain Models [PDF]

, 2011
Whereas research into the characteristics and properties of AI planning algorithms is overwhelming, a similar science of domain model comparison and analysis is underdeveloped. It has long been acknowledged that there can be a range of di erent encodings
Shoeeb, S, McCluskey, T.L., University of Huddersfield   +2 more
core   +3 more sources

The Keivy Domain of the Kola Granulite–Gneiss Area on the Baltic Shield: Most Ancient Median Massif of the Continental Crust

Geosciences, 2023
Studies of lithotectonic formations within the Keivy domain of the NE Baltic Shield have shown that the domain was tectonically overlapped by adjacent microcontinents during regional collision processes in the Late Archean.
Nickolay Sorokhtin, Nikolay Kozlov, Igor Semiletov, Leopold Lobkovsky, Sergey Nikiforov, Dmitry Alekseev, Roman Ananiev   +6 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Paucity and preferential suppression of transgenes in late replication domains of the D. melanogaster genome [PDF]

BMC Genomics, 2010
Abstract Background Eukaryotic genomes are organized in extended domains with distinct features intimately linking genome structure, replication pattern and chromatin state. Recently we identified a set of long late replicating euchromatic regions that are underreplicated in salivary gland polytene chromosomes of D ...
Maroy Peter, Belyakin Stepan N, Maksimov Daniil A, Belyaeva Elena S, Brusentsova Irina V, Makunin Igor V, Babenko Vladimir N, Vasil'eva Lyubov A, Zhimulev Igor F   +8 more
openaire   +3 more sources