Results 81 to 90 of about 4,141,686 (289)
Rivista Italiana di Paleontologia e Stratigrafia, 1997 The Fraele Formation crops out in the Ortles Nappe (upper Valtellina, Northern Italy), structurally part of the Central Austroalpine Domain. It consists of fine siliciclastics alternating with carbonates, mostly limestones,rare dolostones and marls.
FABRIZIO BERRA, SIMONETTA CIRILLI
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The Size of the EU Public Domain [PDF]
, 2012 This paper reports results from a large recent study of the public domain in the European Union. Based on a combination of catalogue and survey data our figures for the number of items (and works) in the public domain extend across a variety of media and
core +3 more sources
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Geology of the Central Sivas Basin (Turkey)
Journal of Maps, 2019 This paper presents a revised geological map at the 1/50,000 scale of the Central Sivas Basin together with a synthetic stratigraphic chart and cross-sections. The map covers an area of approximately 9840 km² within the Eastern Anatolian orogen.
Etienne Legeay +12 more
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Cell Reports, 2019 Summary: Toll-like receptors (TLRs) activate innate immunity via interactions between their Toll/interleukin-1 (IL-1) receptor (TIR) domain and downstream adaptor proteins.
Dan Xiong +11 more
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Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Human cytomegalovirus pUL79 is an elongation factor of RNA polymerase II for viral gene transcription. [PDF]
PLoS Pathogens, 2014 In this study, we have identified a unique mechanism in which human cytomegalovirus (HCMV) protein pUL79 acts as an elongation factor to direct cellular RNA polymerase II for viral transcription during late times of infection.
Yi-Chieh Perng +3 more
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Issues in Planning Domain Model Engineering [PDF]
The paper raises some issues relating to the engineering of domain models for automated planning. It studies the idea of a domain model as a formal specification of a domain, and considers properties of that specification.
Vallati, Mauro +2 more
core +3 more sources