Results 71 to 80 of about 4,141,686 (289)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Contribution of domain wall networks to the CMB power spectrum

open access: yesPhysics Letters B, 2015
We use three domain wall simulations from the radiation era to the late-time dark energy domination era based on the PRS algorithm to calculate the energy–momentum tensor components of domain wall networks in an expanding universe.
A. Lazanu   +2 more
doaj   +1 more source

Improved frequency-domain analysis of ventricular late potentials [PDF]

open access: yesComputers in Cardiology, 2005, 2005
Many methods of segment selection of various lengths and locations in the high-frequency spectral analysis of ventricular late potentials (VLPs) in signal-averaged electrocardiograms (SAECGs) have been demonstrated to yield conflicting results in clinical applications.
openaire   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Maternal and child health care: adequacy index in public health services [PDF]

open access: yesRevista Brasileira de Enfermagem
Objectives: to analyze the adequacy of maternal and child-care in prenatal care, childbirth and the puerperal period, in the public health service.
Flávia Françoso Genovesi   +5 more
doaj   +4 more sources

Positive Effect of Cognitive Reserve on Episodic Memory, Executive and Attentional Functions Taking Into Account Amyloid-Beta, Tau, and Apolipoprotein E Status

open access: yesFrontiers in Aging Neuroscience, 2021
Studies exploring the simultaneous influence of several physiological and environmental factors on domain-specific cognition in late middle-age remain scarce.
Justinas Narbutas   +22 more
doaj   +1 more source

Late Replication Domains in Polytene and Non-Polytene Cells of Drosophila melanogaster

open access: yesPLoS ONE, 2012
In D. melanogaster polytene chromosomes, intercalary heterochromatin (IH) appears as large dense bands scattered in euchromatin and comprises clusters of repressed genes. IH displays distinctly low gene density, indicative of their particular regulation. Genes embedded in IH replicate late in the S phase and become underreplicated.
Elena S Belyaeva   +6 more
openaire   +4 more sources

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Late universe expansion dominated by domain walls and dissipative dark matter

open access: yesPhysical Review D, 2004
15 pages, 2 eps figures, uses revtex4, to be published in Physical Review ...
del Campo, S, Herrera, R, Pavon, D
openaire   +6 more sources

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

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