Results 51 to 60 of about 1,753,266 (286)
Overexpression of the N-terminal domain of TSG101 inhibits HIV-1 budding by blocking late domain function [PDF]
Proceedings of the National Academy of Sciences, 2002 Efficient budding of HIV-1 from the plasma membrane of infected cells requires the function of a 6-kDa protein known as p6. A highly conserved Pro-Thr-Ala-Pro (PTAP) motif (the “late” or “L” domain), is critical for the virus-budding activity of p6. Recently, it was demonstrated that the product of tumor susceptibility gene 101 (TSG101), which contains
Dimiter G, Demirov +3 more
openaire +2 more sources
PLoS Pathogens, 2019 Viral late domains are used by many viruses to recruit the cellular endosomal sorting complex required for transport (ESCRT) to mediate membrane scission during viral budding.
Christopher M Ziegler +12 more
doaj +1 more source
mBio, 2016 Enveloped viruses commonly utilize late-domain motifs, sometimes cooperatively with ubiquitin, to hijack the endosomal sorting complex required for transport (ESCRT) machinery for budding at the plasma membrane. However, the mechanisms underlying budding
Rina Barouch-Bentov +11 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski +9 more
wiley +1 more source
Rivista Italiana di Paleontologia e Stratigrafia, 2007 The Trucco Formation and the Nummulitic Limestone (Dauphinois Domain, Maritime Alps) are characterized by abundant larger foraminifera, specifically nummulitids, orthophragminids and encrusting foraminifera. In the Maritime Alps, previous studies suggest
DARIO VARRONE, DANIELLE DECROUEZ
doaj +1 more source
Late time tails from momentarily stationary, compact initial data in Schwarzschild spacetimes
, 2004 An L-pole perturbation in Schwarzschild spacetime generally falls off at late times t as t^{-2L-3}. It has recently been pointed out by Karkowski, Swierczynski and Malec, that for initial data that is of compact support, and is initially momentarily ...
C. T. Cunningham +2 more
core +1 more source
Hamiltonian Reduction of Diffeomorphism Invariant Field [PDF]
, 1996 For a variety of diffeomorphism-invariant field theories describing hypersurface motions (such as relativistic M-branes in space-time dimension M+2) we perform a Hamiltonian reduction ``at level 0'', showing that a simple algebraic function of the normal
Hoppe, Jens, Ratiu, Tudor
core +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Purpose Although not always achieved, complete chemotherapy‐induced nausea and vomiting (CINV) control is the conventional goal of CINV prophylaxis. In this two‐center, mixed‐methods study, we sought to understand the preferences of adolescent patients and family caregivers for CINV control endpoints.
Haley Newman +8 more
wiley +1 more source
Refined study of the interaction between HIV-1 p6 late domain and ALIX
Retrovirology, 2008 The interaction between the HIV-1 p6 late budding domain and ALIX, a class E vacuolar protein sorting factor, was explored by using the yeast two-hybrid approach. We refined the ALIX binding site of p6 as being the leucine triplet repeat sequence (Lxx)4 (
Gerlier Denis +4 more
doaj +1 more source
Prevalence and Trajectory of Household Material Hardship Among Children With Advanced Cancer
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background/Objectives Families of children with advanced cancer living in poverty experience inferior outcomes including poor parent mental health and worse child quality of life. Household material hardship (HMH: food, housing, transportation, and/or utility insecurity) is a modifiable poverty exposure—and potential intervention target—that ...
Sarah Wright +13 more
wiley +1 more source