Results 41 to 50 of about 7,170 (173)

Latent autoimmune diabetes in adults phenotype with recurrent hypoglycemia as diagnostic challenge (case report)

Mìžnarodnij Endokrinologìčnij Žurnal
Latent autoimmune diabetes in adults (LADA) represents a hybrid form of diabetes characterized by autoimmune destruction of β-cells, clinical features of type 2 diabetes, and a slow progression to insulin dependence.
Teuta Mulla Goga, Afrim Zeqiraj
doaj   +1 more source

GAD65 Antibody Epitopes and Genetic Background in Latent Autoimmune Diabetes in Youth (LADY)

Frontiers in Immunology, 2022
Epitope-specific GAD65Abs and HLA-DR-DQ gene assays help improve the value of risk stratification in autoimmune diabetes mellitus and protect islet function.
Yiman Peng, Xia Li, Yufei Xiang, Xiang Yan, Houde Zhou, Xiaohan Tang, Jin Cheng, Xiaohong Niu, Jing Liu, Qiuhe Ji, Linong Ji, Gan Huang, Zhiguang Zhou   +12 more
doaj   +1 more source

Aniridia‐associated keratopathy: Clinical and molecular mechanisms of disease progression and emerging therapeutic targets

Acta Ophthalmologica, EarlyView.
Abstract Congenital aniridia is a rare genetic disorder primarily caused by pathogenic variants of the PAX6 gene. It leads to various panocular anomalies, including aniridia‐associated keratopathy (AAK). This review highlights recent insights into its pathogenesis, focusing on clinical staging, microstructural changes in the cornea and molecular ...
N. Szentmáry, S. Suiwal, M. Amini, F. N. Fries, A. Náray, L. Latta, Z. Li, S. Li, S. Liu, S. L. Hsu, S. Kundu, G. Tóth, S. Trusen, J. Zimmermann, B. Seitz, B. Käsmann‐Kellner, Z. Hoxha, A. Langenbucher, O. Stachs, M. Cortón‐Perez, K. Tory, A. Csorba, Z. Z. Nagy, M. C. Acosta, J. Gallar, M. Csidey, E. Maka, T. Stachon   +27 more
wiley   +1 more source

The relationship between the cannabinoids and cardiac remodelling: A comprehensive review of pivotal mechanisms and emerging evidence

British Journal of Pharmacology, EarlyView.
Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska, Marta Baranowska‐Kuczko, Hanna Kozłowska   +2 more
wiley   +1 more source

Exogenous Insulin Injection-Induced Stiff-Person Syndrome in a Patient With Latent Autoimmune Diabetes: A Case Report and Literature Review

Frontiers in Endocrinology, 2020
Stiff-person syndrome (SPS) is highly associated with anti-glutamic acid decarboxylase (GAD) antibody. However, GAD antibodies alone appear to be insufficient to cause SPS, and they possibly are involved in only part of its pathophysiology.
Yi-Yin Lee, Cheng-Wei Lin, I-Wen Chen
doaj   +1 more source

Peri‐Implant Crevicular Fluid Analysis by Mid‐Infrared Spectroscopy in Peri‐Implantitis—A Pilot Study

Clinical Oral Implants Research, EarlyView.
ABSTRACT Objectives This study aimed to assess biochemical differences in peri‐implant crevicular fluid (PICF) using ATR‐FTIR spectroscopy and multivariate analysis, through a between‐participant comparison of healthy and peri‐implantitis (PI) sites, and a within‐participant comparison of PI‐PICF and GCF from contralateral periodontal healthy teeth ...
Francisco Maligno, Ricardo N. M. J. Páscoa, Pedro S. Gomes   +2 more
wiley   +1 more source

An international consensus on screening and monitoring early‐stage type 1 diabetes: A roadmap to European implementation

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Type 1 diabetes (T1D) is a chronic autoimmune disease that results in loss of insulin‐secreting pancreatic β‐cells in the islets of Langerhans. A diagnosis of T1D is typically associated with children and adolescents, yet half of all diagnoses of T1D are made in adults.
Sufyan Hussain, Timothy Tree, Chantal Mathieu, Tomasz Klupa, Anna‐Kaisa Tuomaala, Maartje de Wit, Olga Kordonouri, Katarina Braune, Jaivir Pall, Luis Castano, Rachel E. J. Besser, Júlia Galhardo, Francesca Ulivi, Emanuele Bosi, Uroš Bogdanovic, Coralie Alabert, Tadej Battelino   +16 more
wiley   +1 more source

Insulin Autoimmune Syndrome as Part of Pre-Clinical LADA

Diabetes, Metabolic Syndrome and Obesity, 2021
Edyta Sutkowska,1 Malgorzata Ostrowska,2 Magdalena Sutkowska3 1Medical Division, Department and Division of Medical Rehabilitation, Wroclaw Medical University, Wroclaw, Poland; 2Clinical Department of Nephrology and Dialysis Station, Karol Marcinkowski ...
Sutkowska E, Ostrowska M, Sutkowska M
doaj  

Teplizumab in Stage 2 Type 1 Diabetes: Clinical Practice Experience on Feasibility in 3 Adult Patients

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim To describe the first Italian experience with teplizumab administered under a compassionate use programme for adults with Stage 2 type 1 diabetes (T1D), and to evaluate its feasibility, safety and early metabolic outcomes in a real‐life clinical setting outside formal clinical trials.
V. Guarnotta, F. Pantò, E. Vigneri, G. Piombo, M. I. Mineo, L. Tomasello, G. Arnaldi   +6 more
wiley   +1 more source

Glycemic Variability Bridges Time in Range and Time in Tight Range: A Unified Equation for Both Type 1 and Type 2 Diabetes Based on Large‐Scale Continuous Glucose Monitoring Data

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims This study aimed to establish a regression model for the relationship between time in range (TIR) and time in tight range (TITR) in individuals with type 1 diabetes (T1D) and type 2 diabetes (T2D) based on real‐world continuous glucose monitoring (CGM) data.
Yuan Yao, Zhigang Hu, Yifei Mo, Mingsong Han, Li Cao, Jinghao Cai, Xiaojing Ma, Jingyi Lu, Xiaobing Wu, Jian Zhou   +9 more
wiley   +1 more source