Results 171 to 180 of about 2,855 (207)

Lathosterol side chain amides—A new class of human lathosterol oxidase inhibitors

Steroids, 2008
Inhibition of cholesterol biosynthesis offers the opportunity for treatment of cardiovascular diseases. Numerous enzymes are involved in the post-squalene part of this biosynthesis, and selective inhibitors for almost all of the enzymes involved there have been described in literature. The only exception is the enzyme lathosterol oxidase (EC 1.14.21.6),
Martin, Giera, Delphine, Renard, Florian, Plössl, Franz, Bracher   +3 more
openaire   +2 more sources

Metabolism of lathosterol byDrosophila pachea

Lipids, 1971
AbstractDrosophila pachea is a Sonoran Desert cactiphilic species unable to utilize cholesterol or cholestanol for larval growth and maturation. Lathosterol (7‐cholesten‐3β‐ol) was added to a sterol deficient medium on which an axenic culture ofD. pachea was maintained.
K C, Goodnight, H W, Kircher
openaire   +2 more sources

Plasma Lathosterol and Campesterol in Detection of Ileal Dysfunction

Scandinavian Journal of Gastroenterology, 1988
Plasma lathosterol levels reflect cholesterol synthesis, especially that induced by bile acid malabsorption, whereas plasma plant sterol contents change in parallel with cholesterol and fat absorption. The significance of lathosterols and plant sterols (campesterol and sitosterol) was therefore studied in detection of ileal dysfunction in 29 patients ...
M A, Färkkilä, T A, Miettinen
openaire   +2 more sources

Lophenol and lathosterol from resin of Commiphora kua possess hepatoprotective effects in vivo

Journal of Ethnopharmacology, 2020
Drug induced liver damage remains a prevalent concern in healthcare and may reduce the effectiveness of therapy by compromising therapeutic regimens. Many Commiphora species are known for their medicinal properties, and some of them are used traditionally for hepatoprotective effect.
Ullah, Hammad, Khan, Ajmal, Rehman, Najeeb Ur, Halim, Sobia Ahsan, Khan, Haroon, Khan, Imran, Csuk, Rene, Al-Rawahi, Ahmed, Al-Hatmi, Saif, Al-Harrasi, Ahmed   +9 more
openaire   +3 more sources

Determination of changes in serum lathosterol during treatment with simvastatin to evaluate the role of lathosterol as a parameter for whole body cholesterol synthesis

Clinica Chimica Acta, 1993
Serum levels of cholesterol and the cholesterol precursor lathosterol were determined in five healthy volunteers who took 20 mg simvastatin daily during 1 week. During this period and for the following 5 days blood samples were collected. Five days after ingestion of simvastatin, serum lathosterol had already reached a steady-state level and its ...
De Cuyper, I, Wolthers, B G, van Doormaal, J J, Wijnandts, P N   +3 more
openaire   +3 more sources

Cholesterol and Lathosterol in Sebum of X-Irradiated Rats

Radiation Research, 1961
to x irradiation might be detected by analysis of the skin surface fat for products of sebaceous activity. Rats were exposed to 520 r in a single dose or 200 r weekly for 6 weeks and during the eighth week. In general, the level of cholesterol and lathosterol did not differ from that in nonirradiated animals.
Harry Sobel, Yvonne Matesich
openaire   +1 more source

Serum plant sterols and lathosterol related to cholesterol absorption in coeliac disease

Clinica Chimica Acta, 1988
The concentrations of the plant sterols, campesterol and beta-sitosterol in serum, normally correlate with the efficiency of cholesterol absorption, whereas the concentration of lathosterol, a cholesterol precursor sterol, closely parallels changes in cholesterol synthesis.
M, Vuoristo, R, Tilvis, T A, Miettinen
openaire   +2 more sources