Results 71 to 80 of about 307,788 (176)

Characterization, Composition, and Bioactive Potential of Assa-Peixe (Vernonia sp.) Honey

Journal of Food Quality
In this study, pollen content, physicochemical parameters, quantification of phenolics and flavonoids, antioxidant capacity, UV spectrum scan, and substance identification by LC-HRMS were evaluated in Assa-peixe honey.
Pedro Henrique Fonseca Veloso, Lilianny Mendes Soares Araújo, Veronica de Melo Sacramento, Dario Alves de Oliveira, Luciano Fernandes de Souza, Nathália da Costa Pires, Carlos Leomar Zani, Tânia Maria de Almeida Alves, Vanessa de Andrade Royo   +8 more
doaj   +1 more source

Isolation and Characterization of [D-Leu¹]microcystin-LY from Microcystis aeruginosa CPCC-464

Toxins, 2020
[D-Leu1]MC-LY (1) ([M + H]+ m/z 1044.5673, Δ 2.0 ppm), a new microcystin, was isolated from Microcystis aeruginosa strain CPCC-464. The compound was characterized by 1H and 13C NMR spectroscopy, liquid chromatography−high resolution tandem ...
Patricia LeBlanc, Nadine Merkley, Krista Thomas, Nancy I. Lewis, Khalida Békri, Susan LeBlanc Renaud, Frances R. Pick, Pearse McCarron, Christopher O. Miles, Michael A. Quilliam   +9 more
doaj   +1 more source

Hederagenin Attenuates Morphine Addiction via GABAA1‐Mediated Modulation of Ca2+–CaMK–CREB Signaling in Ventral Tegmental Dopaminergic Neurons

Advanced Science, EarlyView.
Hederagenin is identified as a GABAA1‐targeting natural compound that suppresses morphine‐associated reward by restraining Ca2+–CaMK–cAMP–CREB signaling in ventral tegmental dopaminergic neurons. RVG29‐modified liposomal delivery further enhances brain accumulation and behavioral efficacy, providing a mechanistically defined strategy for natural ...
Hongyang Jiang, Ziting Zhou, Nannan Xue, Jiasi Deng, Yuanyuan Zhou, Xinying Lv, Yuxuan Wang, Yi Zhang, Haotian Pan, Geyan Xu, Yinkun Tao, Mengran Li, Xin Cui, Hongyue Ma, Qian Wang, Zhigang Lu   +15 more
wiley   +1 more source

Substrate‐Dependent Crosslinking by the Cytochrome P450 From Aminopyruvatide Biosynthesis

Angewandte Chemie, EarlyView.
Substitutions in the aminopyruvatide precursor peptide altered the C─C linkage formed from a YLY motif by the P450 ApyO to a N─C linkage in a WLY motif. Moreover, constitutional isomers crosslinked by C─C and C─O linkages were formed from YYY or YWY motifs. ABSTRACT Cytochrome P450s catalyze an array of reactions including crosslinking of aromatic side
Chandrashekhar Padhi, Dinh T. Nguyen, Lingyang Zhu, Lide Cha, Jesse W. Wald, Douglas A. Mitchell, Wilfred A. van der Donk   +6 more
wiley   +2 more sources

Combining LC-HRMS and LC-HRMS/MS data to explore a cereal food processed under different conditions

International audienceCharacterizing the chemical fingerprint of a processed food is a major challenge to advance food quality. New untargeted approaches based on LC-HRMS analysis can unlock the potential to increase our understanding on how chemical ...
Camel, Valérie, Rega, Barbara, Ramos, Mélina, Le Roux, Even, Farah, Soha, Cladière, Mathieu   +5 more
core   +4 more sources

Quantification Approaches in Non-Target LC/ESI/HRMS Analysis:An Interlaboratory Comparison [PDF]

Nontargeted screening (NTS) utilizing liquid chromatography electrospray ionization high-resolution mass spectrometry (LC/ESI/HRMS) is increasingly used to identify environmental contaminants.
Malm, Louise, Chrastina, David, Luckute, Austeja, Caupos, Emilie, van der Neut-Marchand, Carla, Roscioli, Claudio, Valdecanas, Belinda, Abis, Pier Paolo, Arturi, Katarzyna, Frigerio, Gianfranco, Fildier, Aurélie, Joerss, Hanna, Peruzzo, Massimo, Garcia-Vara, Manuel, Soulier, Coralie, Christensen, Jan, H, Rostkowski, Pawel, Davis, W. Clay, Mazzetti, Michele, Coppola, Gianluca, Thomaidis, Nikolaos, S, Kochmann, Sven, Aalizadeh, Reza, Wiest, Laure, Thomaidis, Nikolaos S., Verwoert, Milan, Steininger-Mairinger, Teresa, Haelewyck, Niels, Pieke, Eelco, N, SCHYMANSKI, Emma, Plassmann, Merle, Vulliet, Emmanuelle, Nanusha, Mulatu Yohannes, Mebold, Emmanuelle, Christensen, Jan H., Pijnappels, Martijn, Nanusha, Mulatu, Yohannes, Fro̷kjær, Emil Egede, Tisler, Selina, Hollender, Juliane, Talavera Andújar, Begoña, Kunkel, Uwe, Hansen, Martin, Le Roux, Julien, Esperanza, Mar, Kruve, Anneli, Pieke, Eelco N., Davis, W Clay, Fro̷kjær, Emil, Egede, Kumari, Sangeeta, Covaci, Adrian, Letzel, Thomas, Bieber, Stefan, Balest, Lydia, Belova, Lidia, López de Alda, Miren, Gundersen, Hans, Macan Schönleben, Alicia, Helmus, Rick, Murgolo, Sapia, Celma, Alberto, Bijlsma, Lubertus, Davis, W, Clay, Alygizakis, Nikiforos, Schymanski, Emma, L, Valsecchi, Sara, Liigand, Jaanus, Kaserzon, Sarit, Gago-Ferrero, Pablo, Fro Kjær, Emil Egede, Kasprzyk-Hordern, Barbara, Troia, Eugenie, Licul-Kucera, Viktória, Ng, Kelsey, Gil-Solsona, Ruben, Leroy, Gaëla, Vughs, Dennis, Bader, Tobias, Aurich, Dagny, Macherius, André, Pieke, Eelco N, Meekel, Nienke, de Rijke, Eva, Thomaidis, Nikolaos S, Mascolo, Giuseppe, Schulze, Bastian, Abis, Pier, Paolo, Ceolotto, Nicola, Hann, Stephan, Christensen, Jan H, Schymanski, Emma L, Schymanski, Emma L.   +91 more
core   +1 more source

Supramolecular Chiral Assemblies from Benzoselenadiazole‐Alanine‐Acylhydrazone Conjugates Enable Cardioprotection

Advanced Science, EarlyView.
The C3‐symmetric conjugate TASe, which integrates benzoselenadiazole, alanine, and acylhydrazone modules, self‐assembles into a chalcogen‐/hydrogen‐bonded porous framework in the solid state and uniform chiral nanospheres in aqueous media. These assemblies protect cardiomyocytes from doxorubicin‐induced oxidative injury by scavenging intracellular ...
Jinkui Teng, Renjing Yang, Yu Du, Jingzhong Duan, Yiming Xu, Zhihua He, Guanghui Wang, Wenjing Tian, Aijie Liu, Haifeng Chen, Yun‐Bao Jiang, Xiaosheng Yan   +11 more
wiley   +1 more source

Synthesis of Ladder and Flexible Polysulfonimides Directly From Anionic Monomers: Investigating Structure–Property Convergence in Succinonitrile–Polymer Electrolyte Blends

Angewandte Chemie, EarlyView.
Direct synthesis of sulfonimide‐based polymers of intrinsic microporosity enables comparison with compositionally similar flexible analogs. Incorporation of a common pore‐filling transport medium drives these fundamentally different polymer architectures toward similar bulk conductivity and mechanical properties while revealing distinct microscopic ion‐
Abraham Herzog‐Arbeitman, Pablo Leon, Benedikt S. Schreib, KyuJung Jun, Jurgis Ruza, Vanesa Munoz Perales, Yang Shao‐Horn, Rafael Gomez‐Bombarelli, Jeremiah A. Johnson   +8 more
wiley   +2 more sources

HRMS-ESI data of the identified secoiridoids compounds in the EVOO samples.

, 2021
HRMS-ESI data of the identified secoiridoids compounds in the EVOO samples.
Mohamed Seghir Daas (11714538), Laëtitia Fougere (11714541), Massinissa Faci (11714532), Eric Lesellier (11714544), Malika Douzane (5852345), Mariem Hedjal (11714535)   +5 more
core   +1 more source

Adenylation Domain Engineering Enables Biosynthesis of an Improved Polymyxin Antibiotic

Angewandte Chemie, EarlyView.
To enable incorporation of l‐2‐aminodecanoic acid into polymyxin by fermentation, a single Trp‐to‐Ala substitution is rationally introduced into the adenylation‐domain residue of its nonribosomal peptide synthetase (NRPS) and efficiently switches substrate selectivity. The engineered strain produces biologically active Ada‐polymyxin, demonstrating that
Maximilian Müll, Pia Lanvers, Giulia Ravagnan, Kilian Klaus, Olena Nosovska, Ivan Vilotijevic, Jochen Schmid, Hajo Kries   +7 more
wiley   +2 more sources