Results 211 to 220 of about 21,610 (241)
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Untargeted LC-HRMS metabolomics reveals candidate biomarkers for mucopolysaccharidoses
Clinica Chimica Acta, 2023Mucopolysaccharidoses (MPSs) are inherited genetic diseases caused by an absence or deficiency of lysosomal enzymes responsible for catabolizing glycosaminoglycans (GAGs). Undiagnosed patients, or those without adequate treatment in early life, can be severely and irreversibly affected by the disease.
Clarisse L, Torres +4 more
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Steroid profile analysis by LC-HRMS in human seminal fluid
Journal of Chromatography B, 2020Steroids are essential hormones that play a crucial role in homeostasis of many biological processes including sexual development, spermatogenesis, sperm physiology and fertility. Although steroids have been largely studied in many biological matrices (such as urine and plasma), there is very limited information of the steroid content and their study ...
Olesti, Eulalia +7 more
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Identification of etazene (etodesnitazene) metabolites in human urine by LC‐HRMS
Drug Testing and Analysis, 2022AbstractEtazene (or etodesnitazene) is a novel and highly active synthetic opioid belonging to the rapidly evolving and emerging group of “nitazenes.” Etazene metabolites were identified through analysis of a human urine sample. The sample was obtained from a 25‐year‐old man who attempted suicide by taking a new psychoactive substances (NPS) cocktail ...
Nick Verougstraete +4 more
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Detection of secondary cyanobacterial metabolites using LC-HRMS in Lake Karaoun
Science of The Total Environment, 2023Harmful algal blooms events have been reported worldwide and during the last decades are occurred with increasing frequency and intensity due to the climate change and the high inputs of nutrients in freshwaters from anthropogenic activities. During blooms cyanobacteria release in water their toxic secondary metabolites, known as cyanotoxins, along ...
Sevasti-Kiriaki, Zervou +5 more
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Lipidomic analysis of geopropolis of Brazilian stingless bees by LC-HRMS
Food Research International, 2023Stingless bees (Meliponini) represent over than 500 species, found in tropical and sub-tropical regions of the world. They produce geopropolis, a resinous natural product containing bioactive compounds, which is commonly used in folk medicine. In the current study, LC-HRMS and bioinformatic tools were used to carry out for the first time the lipidomic ...
João, Fabio Turco +2 more
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Characterization of Phlorotannins from Brown Algae by LC-HRMS
2015Phlorotannins are a class of polyphenols found in brown seaweeds that have significant potential for use as therapeutics, owing to their wide range of bioactivities. Molecular characterization of phlorotannin-enriched extracts is challenging due to the extreme sample complexity and the wide range of molecular weights observed.
Melanson, Jeremy E. +1 more
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Simultaneous LC-HRMS determination of 28 benzodiazepines and metabolites in hair
Analytical and Bioanalytical Chemistry, 2011A liquid chromatography-high resolution mass spectrometry (LC-HRMS) method for the simultaneous identification and quantification of 28 benzodiazepines, including 6 metabolites, in 50 mg of hair has been validated. Positive ion electrospray ionization and HRMS determination in full-scan mode were realized on an Orbitrap mass spectrometer at a nominal ...
VOGLIARDI, SUSANNA +4 more
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Human plasma ricinine quantification by LC–HRMS after micro‐solid‐phase elution
Biomedical Chromatography, 2023AbstractA rapid, sensitive and specific method for ricinine identification and quantification in plasma has been developed by LC–HRMS. Deuterated ricinine was used as the internal standard. From 100 μL of plasma, ricinine was extracted using micro‐solid‐phase elution, which allows a reduced extraction time, by eliminating the evaporation step.
Pauline Thiebot +8 more
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A sensitive method detecting trace levels of levonorgestrel using LC-HRMS
Contraception, 2019To develop a high resolution mass spectrometry (HRMS) method to quantify levonorgestrel (LNG) in serum.Levonorgestrel was extracted using solid phase extraction and measured using liquid chromatography (LC) HRMS.Low limit of quantification (LLOQ) was 25 pg/mL and low limit of detection (LLOD) was 12.5 pg/mL. Precision and accuracy bias were
Sandy, Abujrais +6 more
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LC-HRMS studies on ruxolitinib degradation: a comprehensive approach during drug development
Analytical Methods, 2022Ruxolitinib degrdation products and their elution behaviour for impurity profilling.
Harsh Thakkar +3 more
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