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Detection of secondary cyanobacterial metabolites using LC-HRMS in Lake Karaoun

Science of The Total Environment, 2023
Harmful algal blooms events have been reported worldwide and during the last decades are occurred with increasing frequency and intensity due to the climate change and the high inputs of nutrients in freshwaters from anthropogenic activities. During blooms cyanobacteria release in water their toxic secondary metabolites, known as cyanotoxins, along ...
Sevasti-Kiriaki, Zervou   +5 more
openaire   +2 more sources

Characterization of Phlorotannins from Brown Algae by LC-HRMS

2015
Phlorotannins are a class of polyphenols found in brown seaweeds that have significant potential for use as therapeutics, owing to their wide range of bioactivities. Molecular characterization of phlorotannin-enriched extracts is challenging due to the extreme sample complexity and the wide range of molecular weights observed.
Melanson, Jeremy E.   +1 more
openaire   +3 more sources

Modular, Scalable, and Customizable LC-HRMS for Exposomics

In this chapter, we describe a multi-purpose, reversed-phase liquid chromatography-high-resolution mass spectrometry (LC-HRMS) workflow for acquiring high-quality, non-targeted exposomics data utilizing data-dependent acquisition (DDA) combined with the use of toxicant inclusion lists for semi-targeted analysis.
Vinicius Verri, Hernandes   +1 more
openaire   +2 more sources

Suzetrigine in Equestrian Sports: Optimized Extraction and LC-HRMS Detection Strategies

Rapid Communications in Mass Spectrometry
ABSTRACT Rationale Suzetrigine, a recently approved Na V 1.8 sodium channel blocker, shows strong potential in the treatment of neurological, psychiatric, and pain‐related conditions. Its peripheral selectivity enables effective
Meleparappil Muhammed Ajeebsanu   +5 more
openaire   +2 more sources

LC-HRMS- and TLC-based metabolomics for the identification and authentication of Sida rhombifolia

Journal of Chromatography B
Ensuring the authenticity and quality of Sida rhombifolia raw materials is crucial for its herbal medicinal product's consistent efficacy, quality, and safety. In this study, we developed an identification and authentication method for identifying and authenticating S. rhombifolia from Turnera subulata. T.
Uswatun, Hasanah   +7 more
openaire   +2 more sources

Quantification of Efavirenz Hydroxymetabolites in Human Plasma Using LC-HRMS/MS

Therapeutic Drug Monitoring
Background: Efavirenz (EFV) is a drug used to treat HIV. Low plasma concentrations of EFV result in suboptimal viral suppression, whereas high concentrations can cause adverse neuropsychiatric side reactions. Some studies have identified a correlation between the plasma concentrations of EFV metabolites and neurotoxicity.
Madeleine, Pettersson Bergstrand   +6 more
openaire   +2 more sources

Identification of etazene metabolites in human urine by LC-HRMS

Toxicologie Analytique et Clinique, 2022
Nick Verougstraete, Alain Verstraete
openaire   +1 more source

The Application of UHPLC-HRMS for Quality Control of Traditional Chinese Medicine

Frontiers in Pharmacology, 2022
Kailin Li, Lianghong Liu, Li Kailin
exaly  

2D LC HRMS analysis of bivalirudin and its degradation products

2019
Bivalirudin is a direct thrombin inhibitor which is used as anticoagulant for patients with acute coronary syndromes or patients undergoing percutaneous coronary intervention [1]. It is a synthetic oligopeptide, consists of 20 amino acids (D-Phe-Pro-Arg-Pro-Gly-Gly-Gly-Gly-Asn-Gly- Asp- Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu), and specifically binds to ...
Vukoja, Andreja   +2 more
openaire   +2 more sources

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