Results 131 to 140 of about 100,610 (290)

Lactylation Reprogramming in the Bone Infection Microenvironment Identifies PGK1 K361 as a Potential Therapeutic Target for Osteogenic Dysfunction

Advanced Science, EarlyView.
Staphylococcus aureus (S. aureus) infection creates a high‐lactate microenvironment, promoting p300‐mediated lactylation of PGK1 at lysine 361 (K361). Lactylated PGK1 translocates to the mitochondrial outer membrane and interacts with VDAC3. This interaction triggers FtMt downregulation, iron accumulation, and excessive PINK1/Parkin‐mediated mitophagy,
Han‐jun Qin, Si‐ying He, Ting‐hui Xiao, Da‐mao Dai, Xin‐jia Hu, Nan Jiang   +5 more
wiley   +1 more source

The autophagy-related protein LC3 is processed in stallion spermatozoa during short-and long-term storage and the related stressful conditions

Animal, 2016
Use of cooled and frozen semen is becoming increasingly prevalent in the equine industry. However, these procedures cause harmful effects in the sperm cell resulting in reduced cell lifespan and fertility rates.
I.M. Aparicio, P. Martin Muñoz, G.M. Salido, F.J. Peña, J.A. Tapia   +4 more
doaj   +1 more source

Design and Verification of LC3 Microcontroller

International Journal for Research in Applied Science and Engineering Technology, 2022
Abstract: The main focus of the work is on utilising System Verilog to verify and debug the LC-3 Microcontroller, a 16-bit RISC processor. The utilised LC-3 Design Under Test (DUT) contains numerous flaws in the Fetch, Decode, Execute, and Controller sub-design units as well as flaws throughout.
openaire   +1 more source

Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets [PDF]

Nature Communications
AbstractRecent successes in developing small molecule degraders that act through the ubiquitin system have spurred efforts to extend this technology to other mechanisms, including the autophagosomal-lysosomal pathway. Therefore, reports of autophagosome tethering compounds (ATTECs) have received considerable attention from the drug development ...
Martin P. Schwalm, Johannes Dopfer, Adarsh Kumar, Francesco A. Greco, Nicolas Bauer, Frank Löhr, Jan Heering, Sara Cano-Franco, Severin Lechner, Thomas Hanke, Ivana Jaser, Viktoria Morasch, Christopher Lenz, Daren Fearon, Peter G. Marples, Charles W. E. Tomlinson, Lorene Brunello, Krishna Saxena, Nathan B. P. Adams, Frank von Delft, Susanne Müller, Alexandra Stolz, Ewgenij Proschak, Bernhard Kuster, Stefan Knapp, Vladimir V. Rogov   +25 more
openaire   +4 more sources

Mezclas de hormigón sustentable con puzolanas naturales: perspectiva global, escenarios sudamericanos y casos en Ecuador

NOVASINERGIA
El propósito de esta investigación es determinar si las mezclas de cemento de bajo carbono producidas con puzolanas naturales de Ecuador, como la ceniza volcánica y la arcilla calcinada, constituyen una opción técnica y ecológicamente eficiente en ...
Henry Ramos, Andrés Bastidas, Heraldo Mosquera, Julián Quishpe   +3 more
doaj   +1 more source

Bacterial Pigments as Potential Antitumor Agents Against Gastrointestinal Cancers: A Comprehensive Systematic Review

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Gastrointestinal cancers (GICs) constitute one of the leading causes of cancer‐related morbidity and mortality worldwide. Despite currently available therapeutic strategies, new approaches and procedures are needed for their prevention and treatment.
Raúl Vergara, Ricardo F. S. Pereira, Carla C. C. R. de Carvalho, Jose Prados, Consolación Melguizo, Raul Ortiz   +5 more
wiley   +1 more source

The dynamics of biomarkers of autophagy and neuroinflammation in the acute period of atherothrombotic ischemic stroke

Медицинская иммунология
Postischemic neuroinflammation is a critical pathophysiological process within the entire pattern of cerebral ischemia. It is characterized by microglial and astroglial activation and is accompanied by disturbances in the innate and adaptive immune ...
A. V. Lugovaya, N. M. Kalinina, A. M. Ivanov, Yu. V. Nikitin, I. A. Sukhina, V. P. Mitreikin, S. Sh. Zabirov, G. E. Kirilkin   +7 more
doaj   +1 more source

La phagocytose associée à LC3 (LAP) LC3-Associated Phagocytosis (LAP) - Phagocytosis or Autophagy?

, 2019
Phagocytose et macroautophagie, appelée ici autophagie, sont deux mécanismes essentiels de dégradation lysosomale de divers cargos englobés dans des structures membranaires. Ils sont tous deux impliqués dans la régulation du système immunitaire et la survie cellulaire. Cependant, la phagocytose permet l’ingestion de matériel extracellulaire alors que l’
Galais, Mathilde, Pradel, Baptiste, Vergne, Isabelle, Robert-Hebmann, Véronique, Espert, Lucile, Biard-Piechaczyk, Martine   +5 more
openaire   +1 more source

Multifunctional H2S‐activated metal‐organic framework systems for targeted colorectal cancer imaging and synergistic copper‐induced tumor regression

BMEMat, EarlyView.
The in situ reaction of Cu‐MOFs with endogenous H2S enabled PA imaging and facilitated combined PTT/chemotherapy for colorectal cancer therapy. Abstract Stimuli‐responsive nanomaterials offer significant potential for enhancing diagnostic accuracy, optimizing therapeutic efficacy, and advancing precision theranostics.
Nannan Zheng, Qinghui Wang, Zhiyue Cao, Chao Yu, Renkai Zhang, Kaiyan Xiang, Haoguang Wu, Kai Li, Qianqian Ni, Qiuyue Ma, Jing Mu, Xiaoyuan Chen, Liangcan He, Shaoqin Liu   +13 more
wiley   +1 more source

Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment

BMEMat, EarlyView.
Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan, Qiujie Fang, Cao Fei, Ziyuan Wang, Zhaowei Chen, Guojun Chen, Zhiming Xu, Shu Xu, Zhitong Chen   +8 more
wiley   +1 more source