Results 151 to 160 of about 63,437 (218)

STING Modulating ER-Phagy in the Prelimbic Cortex Neurons Contributed to Neuropathic Pain and Emotional Comorbidity. [PDF]

CNS Neurosci Ther
SNL induced ER‐phagy impairment and ER stress increase in the PrL neuron via STING and the STING pathway. Our data indicated that enhancing ER‐phagy in PrL neurons might provide analgesic and antidepressant effects through STING and its pathways in SNL mice. ABSTRACT Background Our previous data suggested that autophagy is crucial for neuropathic pain.
Liu Y, Yang X, Kuai S, Chen X, Wang Z, Yang Z, Guo X, He X, Zhao P.   +8 more
europepmc   +2 more sources

A Quarter Century of EHD Protein Research: From Endosomal Recycling to Ciliopathies

Traffic, Volume 27, Issue 3, September 2026.
Human EHD protein subcellular localization. ABSTRACT Eps15 homology domain‐containing proteins comprise a conserved family of membrane‐remodeling ATPases that regulate endocytic trafficking, membrane fission, receptor recycling, primary ciliogenesis and membrane dynamics across eukaryotes. Since the initial identification of EHD1 and its Caenorhabditis
Devin Frisby, Gunjan Misri, Naava Naslavsky, Steve Caplan   +3 more
wiley   +1 more source

The H3K9me2-FOXG1-microRNA axis reduces cochlear hair cells damage by modulating autophagy in age-related hearing loss. [PDF]

Front Mol Neurosci
Wen S, Huang Y, Mu Y, Li C, Xu B, Zou S, Wei C, Lin K, Wu T, Zhang P, He Z.   +10 more
europepmc   +1 more source

Unravelling the Significance of Cystatin C and Bunina Bodies in Amyotrophic Lateral Sclerosis Pathogenesis

Neuropathology and Applied Neurobiology, Volume 52, Issue 4, August 2026.
ABSTRACT Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND), is a fatal neurodegenerative disease primarily affecting motor neurons. Two key protein inclusions found in lower motor neurons serve as neuropathological hallmarks of the disease in human tissue: the TDP43‐positive inclusion and the cystatin C‐positive Bunina body.
Sarah M. Granger, Rosemary A. Staniforth, Asbjorg Osk Snorradottir, Johnathan Cooper‐Knock, Kurt J. De Vos, J. Robin Highley   +5 more
wiley   +1 more source

E2F4 Mediates Mitophagy to Inhibit Ferroptosis in Esophageal Cancer Cells by Activating GPR176. [PDF]

Hum Mutat
Xu W, Su F, Xie L, Ding T, Qi X, Chen P, Ye Z, Lin W.   +7 more
europepmc   +1 more source

Advances in the Neurotoxic Mechanisms of Acrylamide and Multitarget Intervention Strategies of Natural Products

Food Frontiers, Volume 7, Issue 4, July 2026.
This review summarizes recent advances in acrylamide neurotoxicity mechanisms and highlights the multitarget neuroprotective effects of diverse natural products while also addressing current challenges and future translational research directions.
Wen Du, Yifan Zhao, Li Dong, Chen Ma, Xiaosong Hu, Daotong Li, Fang Chen, Yinghua Luo   +7 more
wiley   +1 more source

Gambogic acid induces cell death via covalent binding with PRDX1 to regulate ER stress and autophagy. [PDF]

Chin Med
Wang J, Zhang W, Yang L, Zhong X, Ou J, Iyaswamy A, Gu X, Yang C, Guo B, Shi M, Wang J.   +10 more
europepmc   +1 more source

Exosome Secretion Drives Chemo‐Resistance of Temozolomide in Glioblastoma

Journal of Extracellular Biology, Volume 5, Issue 7, July 2026.
ABSTRACT Temozolomide (TMZ) is a first‐line chemotherapeutic agent for the treatment of glioblastoma (GBM), while a majority of patients do not effectively respond to TMZ owing to the multiple resistance mechanisms. In this study, we found that TMZ treatment substantially increased the exosome secretion from GBM cell line.
Wenpei Li, Shaoping Jiang, Kun Liu, Zhi Li, Jun Yang, Weimin Liu, Yuanyu Huang, Minghui Yang, Shuai Guo, Shaobo Ruan   +9 more
wiley   +1 more source

The Role of Sigmar1 in Autophagy Regulation and Disease Therapy. [PDF]

Int J Mol Sci
Ge H, Lin Y, Li J, Zhang R, Xu C.
europepmc   +1 more source