MedComm, Volume 7, Issue 7, July 2026.Under physiological conditions, pathogenic stimuli activate TLR/IL1‐R signaling, triggering TOLLIP dissociation from IRAK1 and subsequent IRAK1 phosphorylation, TRAF6 ubiquitination, and NF‐κB activation. During SARS‐CoV‐2 infection, viral M protein binds TOLLIP and stabilizes the TOLLIP–IRAK1 complex, thereby suppressing NF‐κB signaling, impairing ...
Yabin Zhang +10 more
wiley +1 more source
Copper Overload Affects α-Synuclein Clearance Mechanisms in a Parkinson's Disease In Vitro Model. [PDF]
Adv Biol (Weinh)Musarò D +4 more
europepmc +1 more source
Ischemia–Reperfusion Injury: Molecular Mechanisms and Therapeutic Interventions
MedComm, Volume 7, Issue 7, July 2026.Multiorgan ischemia–reperfusion injury begins with ischemia‐induced ATP depletion and ionic imbalance, followed by reperfusion‐triggered mitochondrial ROS/RNS bursts, regulated cell death, and DAMP release. Sterile inflammation converges on endothelial–immune–coagulation crosstalk, where NETs drive immunothrombosis, no‐reflow, and remote organ injury ...
Peng An +4 more
wiley +1 more source
ADAR1-circRAB5A-BIP axis governs radiotherapy resistance in colorectal cancer through coordinating protective autophagy and apoptosis. [PDF]
Cancer Biol TherChen W +5 more
europepmc +1 more source
Urologic Bacteriome: The Hero or the Villain in Prostate Cancer Onset, Progression, and Treatment?
Medicinal Research Reviews, Volume 46, Issue 4, Page 1111-1151, July 2026.ABSTRACT Prostate cancer (PCa) is the second most frequently diagnosed cancer in men worldwide and the fifth leading cause of cancer‐related mortality, presenting urgent unmet clinical needs in diagnosis and treatment. The recognition of the microbiome as a key factor in human health has prompted numerous studies, revealing an exciting new approach to ...
Lara R. S. Fonseca +6 more
wiley +1 more source
Oxidative Stress-Induced Age-Related Bullous Keratopathy in Corneal Endothelial Cells With Lipid Droplets and Vacuoles. [PDF]
Invest Ophthalmol Vis SciOnouchi H +7 more
europepmc +1 more source
Humanin Mitigates Aβ‐Induced Retinal Pigment Epithelium Injury via AMPK‐Beclin1‐Dependent Mitophagy
Aging Cell, Volume 25, Issue 7, July 2026.Humanin (HN) enhanced the clearance of Aβ‐accumulated mitochondria in the RPE while preserving retinal function and RPE barrier integrity. HN activated AMP‐activated protein kinase (AMPK), leading to phosphorylation of ULK1 and Beclin1, which promoted the interaction between Beclin1 and Parkin and their translocation to mitochondria.
Ha Young Jang +7 more
wiley +1 more source
ULK1 mediated autophagy in airway cells during <i>Aspergillus</i> infection. [PDF]
Front MicrobiolChen F +10 more
europepmc +1 more source
Aging Cell, Volume 25, Issue 7, July 2026.This review systematically elucidates the multifactorial anti‐aging mechanisms of extracellular vesicles (EVs). By bridging fundamental biology with advanced bioengineering, scalable manufacturing, and clinical translation, it establishes a comprehensive framework for developing next‐generation EVs‐based precision nanotherapeutics to combat systemic ...
Xian Huang +6 more
wiley +1 more source
Tissue Factor-inhibited Beclin1-autophagy via BCL2 overexpression suppresses the differentiation of human monocytes into mature osteoclasts. [PDF]
Genet Mol BiolWu L, Gao T, Ke D, Liu G.
europepmc +1 more source