Results 161 to 170 of about 125,401 (357)

Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment

BMEMat, EarlyView.
Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan, Qiujie Fang, Cao Fei, Ziyuan Wang, Zhaowei Chen, Guojun Chen, Zhiming Xu, Shu Xu, Zhitong Chen   +8 more
wiley   +1 more source

Escape of Actively Secreting Shigella flexneri from ATG8/LC3-Positive Vacuoles Formed during Cell-To-Cell Spread Is Facilitated by IcsB and VirA

mBio, 2015
The enteropathogenic bacterium Shigella flexneri uses a type 3 secretion apparatus (T3SA) to transfer proteins dubbed translocators and effectors inside host cells, inducing bacterial uptake and subsequent lysis of the entry vacuole.
François-Xavier Campbell-Valois, Martin Sachse, Philippe J. Sansonetti, Claude Parsot   +3 more
doaj   +1 more source

Transient increases in intracellular calcium and reactive oxygen species levels in TCam-2 cells exposed to microgravity [PDF]

, 2017
The effects of microgravity on functions of the human body are well described, including alterations in the male and female reproductive systems. In the present study, TCam-2 cells, which are considered a good model of mitotically active male germ cells,
Catizone, A, Guarnieri, S, Mariggiò, M. A., Morabito, C, Ricci, G, Schiraldi, C   +5 more
core   +2 more sources

Design and Verification of LC3 Microcontroller

International Journal for Research in Applied Science and Engineering Technology, 2022
Abstract: The main focus of the work is on utilising System Verilog to verify and debug the LC-3 Microcontroller, a 16-bit RISC processor. The utilised LC-3 Design Under Test (DUT) contains numerous flaws in the Fetch, Decode, Execute, and Controller sub-design units as well as flaws throughout.
openaire   +1 more source

Nanomaterials‐mediated glycolysis rewriting to potentiate tumor immunotherapy

BMEMat, EarlyView.
This review systematically summarizes cutting‐edge advances in glycolysis‐rewiring nanomedicines, emphasizing their mechanisms in reversing immunosuppression and reinvigorating antitumor immune responses. Challenges in clinical translation and future directions for designing multifunctional metabolic‐immune modulators are also critically discussed ...
Zilin Ma, Songyan Li, Jie Yan, Xuechun Wang, Wen Zhao, Yunxuan Song, Dongdong Liu, Jianwei Jiao, Xiuying Duan, Guiqiang Zhang   +9 more
wiley   +1 more source

The autophagy-related protein LC3 is processed in stallion spermatozoa during short-and long-term storage and the related stressful conditions

Animal, 2016
Use of cooled and frozen semen is becoming increasingly prevalent in the equine industry. However, these procedures cause harmful effects in the sperm cell resulting in reduced cell lifespan and fertility rates.
I.M. Aparicio, P. Martin Muñoz, G.M. Salido, F.J. Peña, J.A. Tapia   +4 more
doaj   +1 more source

Ursolic acid enhances macrophage autophagy and attenuates atherogenesis [PDF]

, 2016
Macrophage autophagy has been shown to be protective against atherosclerosis. We previously discovered that ursolic acid (UA) promoted cancer cell autophagy.
Fan, Daping, Iwanowycz, Stephen, Leng, Shuilong, Razani, Babak, Saaoud, Fatma, Sergin, Ismail, Wang, Junfeng, Wang, Yuzhen   +7 more
core   +2 more sources

Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets [PDF]

Nature Communications
AbstractRecent successes in developing small molecule degraders that act through the ubiquitin system have spurred efforts to extend this technology to other mechanisms, including the autophagosomal-lysosomal pathway. Therefore, reports of autophagosome tethering compounds (ATTECs) have received considerable attention from the drug development ...
Martin P. Schwalm, Johannes Dopfer, Adarsh Kumar, Francesco A. Greco, Nicolas Bauer, Frank Löhr, Jan Heering, Sara Cano-Franco, Severin Lechner, Thomas Hanke, Ivana Jaser, Viktoria Morasch, Christopher Lenz, Daren Fearon, Peter G. Marples, Charles W. E. Tomlinson, Lorene Brunello, Krishna Saxena, Nathan B. P. Adams, Frank von Delft, Susanne Müller, Alexandra Stolz, Ewgenij Proschak, Bernhard Kuster, Stefan Knapp, Vladimir V. Rogov   +25 more
openaire   +4 more sources

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

Mezclas de hormigón sustentable con puzolanas naturales: perspectiva global, escenarios sudamericanos y casos en Ecuador

NOVASINERGIA
El propósito de esta investigación es determinar si las mezclas de cemento de bajo carbono producidas con puzolanas naturales de Ecuador, como la ceniza volcánica y la arcilla calcinada, constituyen una opción técnica y ecológicamente eficiente en ...
Henry Ramos, Andrés Bastidas, Heraldo Mosquera, Julián Quishpe   +3 more
doaj   +1 more source