Results 161 to 170 of about 100,610 (290)
Uncovering the Complexity of Synucleinopathies: An Ongoing Tale Between Proteins and Lipids
Movement Disorders, EarlyView.Abstract Neurodegenerative diseases are pathological states characterized by progressive alterations in brain homeostasis during aging. Synucleinopathies, including Parkinson's disease and dementia with Lewy bodies, are defined neuropathologically by the accumulation of inclusions known as Lewy bodies and Lewy neurites.
Manuel Flores‐León, Tiago F. Outeiro
wiley +1 more source
Movement Disorders, EarlyView.Abstract Background Membrane contact sites are crucial for the exchange of ions or lipids and thus are critical for the function and maintenance of organelles. VPS13A is a membrane‐residing, bridge‐like protein connecting two membranes to enable bulk lipid transfer. Loss‐of‐function mutations in the VPS13A gene cause VPS13A disease.
Dajana Grossmann +10 more
wiley +1 more source
Nigericin‐Triggered Phosphodynamics in Inflammasome Formation and Pyroptosis
PROTEOMICS, EarlyView.ABSTRACT Innate immune signaling relies heavily on phosphorylation cascades to mount effective immune responses. Although traditional innate immune signaling cascades following TLR4 stimulation have been investigated through a temporally quantitative phosphoproteomic lens, far fewer studies have applied these methods to distinct signaling following the
Vanya Bhushan +5 more
wiley +1 more source
Phytotherapy Research, EarlyView.ABSTRACT Psychological stress (or simply “stress”) is a major contributor to chronic disease worldwide, affecting 35% of the global population, including younger generations. Furthermore, it plays a significant role in human premature aging; hence, its detrimental effects on people's health compel us to comprehend and control the ways in which ...
Marco Duarte +3 more
wiley +1 more source
Role of autophagy in lipid aggregation in lipid-induced renal tubular epithelial damage
Linchuang shenzangbing zazhi, 2016 Objective To investigate the role of autophagy in lipid aggregation in lipid-induced renal tubular epithelial damage.Methods Renal tubular epithelial cells(HK-2) were incubated with low density lipoprotein(LDL) at different concentrations(0,20 μg/ml,50 ...
WANG Rui, ZHANG Ning
doaj
Rare Metals, EarlyView.ABSTRACT Intervertebral disc degeneration (IDD) is a predominant cause of low back pain, significantly impacting quality of life. Mitochondrial fitness is essential in the progression of IDD, as it regulates cellular senescence and pyroptosis. This study investigates the role of mitochondrial caseinolytic protease P (ClpP) in alleviating senescence and
Kun Wang +7 more
wiley +1 more source
New Advances of Degradable Magnesium‐Based Metal Biomaterials in the Field of Orthopedics
Rare Metals, EarlyView.ABSTRACT Based on their outstanding biomechanical properties and superior osteogenic activity, magnesium (Mg) and its alloys have been extensively investigated for their biocompatibility and therapeutic efficacy in treating fractures and bone defects.
Jia‐Nan Yu +8 more
wiley +1 more source
Journal of Field Robotics, EarlyView.ABSTRACT This paper details the design and development of SensHB.Q, a force‐sensitive handlebar intended for caregivers driving electric‐powered wheelchairs, particularly those with omnidirectional mobility. The same interface can also be used in the future to operate other omnidirectional motorized systems, such as mobile robots, hospital beds, and ...
Luigi Tagliavini, Giuseppe Quaglia
wiley +1 more source
Targeting the SIRT1‐NAT10‐GABABR1 Axis: A Novel Epitranscriptomic Approach to Mitigate Sevoflurane‐Induced Cognitive Impairment in Aging [PDF]
CNS Neurosci TherThe study reveals that NAT10 enhances GABABR1 mRNA stability via ac4A modification, leading to excessive inhibitory synaptic activation. In aged rats, sevoflurane contributes to cognitive impairment by inhibiting Sirt1 and neuronal autophagy, which subsequently disrupts energy metabolism.
Xie X, Du W, Zhang Y, Zhang X.
europepmc +2 more sources