Results 241 to 250 of about 100,610 (290)

Scoparone induces mitophagy and apoptosis via ROS accumulation in pancreatic cancer cells. [PDF]

Curr Res Toxicol
Weng N, Lin L, Lin T, Liu J, Zhu K, Huang S.   +5 more
europepmc   +1 more source

Sex‐specific acceleration of Alzheimer's pathogenesis by chronic sleep‐deprivation

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Sleep impairments likely contribute to Alzheimer's pathology, though specific contributions to disease progression are incompletely understood. We propose that autophagic impairment is associated with chronic sleep disruption and examine how sleep loss and stress influence disease development, including having impacts on ...
Darcy Wear, Christopher Daniel Morrone, Dominic Simpson, Fang Liu, Syed Abid Hussaini, Wai Haung Yu   +5 more
wiley   +1 more source

Expression profiling reveals coordinated dysregulation of autophagy-associated proteins in marginal zone lymphoma and therapeutic implications. [PDF]

Oncol Lett
Ruan J, Zhou X, Li A, Shan N.
europepmc   +1 more source

Insufficient Expression of the Autophagic Protein ATG16L1 Results in Accelerated Carcinogenesis Related to an Aberrant B Cell Response

Cancer Reports, Volume 9, Issue 2, February 2026.
ABSTRACT Background Autophagy‐related proteins (ATGs) regulate a great variety of cellular responses beyond autophagy. In cancer, the role of ATG proteins is central, as evidenced in spontaneous cancer emerging in animals lacking ATG proteins. Aim To determine whether ATG16L1 may be participating in tumorigenesis in colonic and oral mucosa and its ...
Daniela Mendiola, Betsaida Ortiz, Oscar Nieto, Marisol I. González, Danielle Vannan, Bertus Eksteen, Alejandro Martínez, Diego Mateos, Mónica G. Mendoza‐Rodríguez, Miriam Rodríguez‐Sosa, Luis I. Terrazas, José L. Reyes   +11 more
wiley   +1 more source

Hypoxia-triggered autophagy modulates cisplatin resistance in non-small cell lung Cancer via EIF2AK3-dependent PI3K/AKT signaling and mTOR-independent mechanisms. [PDF]

Cell Death Discov
Fu J, Xu W, Wang G, Zeng L, Xian L, Wei Y, Zhang J.   +6 more
europepmc   +1 more source

CARMN loss promotes VSMC-derived foam cell formation and atherosclerosis through transcriptional downregulation of autophagy. [PDF]

Cell Death Dis
Huang T, Tang Y, Su Q, Su C, Wang J, Fu L, Tang Y.   +6 more
europepmc   +1 more source

β‐Asarone Attenuates Neuroinflammation of Alzheimer's Disease by Activating Autophagy and Suppressing NLRP3 Inflammasome Assembly

CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.
β‐amyloid activates microglia via the TLR/NF‐κB pathway and primes the NLRP3 inflammasome, driving neuroinflammation. β‐asarone counteracts this by activating autophagy, which degrades NLRP3 components and inhibits inflammasome assembly. This reduces IL‐1β maturation, suppresses cytokine release, and alleviates neuronal damage and cognitive deficits in
Zhiwei Xu, Wanying Xu, Jinxin He, Jiahui Qian, Hui Wang, Changyu Li, Xiaojie Zhou   +6 more
wiley   +1 more source

PRDX1 promotes testosterone synthesis and attenuates aging via redox regulation of ATG4B to modulate lipophagy. [PDF]

Nat Commun
Zhang H, Ma K, Zhuang Y, Cen X, Zhang X, Ruan S, Feng H, Yi R, Huang Z, Huang C, Xie M, Tang L, Cao X, Zhang G, Kang X, Fan Y, Chen Z.   +16 more
europepmc   +1 more source

Metabolic reprogramming of efferocytosis in the tumour microenvironment: From apoptotic‐cell clearance to therapeutic targeting

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
This review systematically deconstructs the pathological efferocytic—metabolic axis in tumours, framing it as a three‐stage, self‐reinforcing cycle: from metabolite‐driven macrophage recruitment, through hijacked surface recognition, to post‐phagocytic metabolic reprogramming that locks in immunosuppression.
Qianlu Yang, Jie Yan, Qianxi Yang
wiley   +1 more source

D-limonene modulates AMPK signaling to inhibit ox-LDL-induced foam cell formation. [PDF]

Sci Rep
Luo G, Fang F, Guo Y, Li Y, Luo X.
europepmc   +1 more source