Results 81 to 90 of about 63,437 (218)
Cell ReportsSummary: Autophagosome formation initiated on the endoplasmic reticulum (ER)-associated omegasome requires LC3. Translational regulation of LC3 biosynthesis is unexplored.
Jeffrey Knupp +4 more
doaj +1 more source
Synthetic Strategies for Activity‐Based Probes to Decode Ubiquitin‐Like Modifiers
Chemistry – A European Journal, EarlyView.ABSTRACT Ubiquitin‐like proteins (Ubls) such as SUMO, NEDD8, ISG15, URM1, UFM1, FAT10, ATG8/ATG12, and FUBI are essential regulators of cellular homeostasis, controlling processes from protein stability and trafficking to immune signaling and autophagy.
Saibal Chanda +5 more
wiley +1 more source
Post‐LECA Origin and Diversification of an Axonemal Outer Arm Dynein Motor
Cytoskeleton, EarlyView.ABSTRACT Dyneins were present in the last eukaryotic common ancestor (LECA) and play key roles in eukaryotic biology. Axonemal dyneins form the inner and outer arms that power ciliary beating, and it has long been recognized that outer arms in some organisms contain two different heavy chain motors, whereas those from other species contain a third unit
Stephen M. King
wiley +1 more source
Investigating the Cytoskeleton of DRGs Using Cryo‐Electron Microscopy and Deep Learning
Cytoskeleton, EarlyView.ABSTRACT We describe a method for determining the ultrastructural organization of axons and varicosities of cultured dorsal root ganglion (DRG) neurons using cryogenic electron microscopy (cryo‐EM). Cryo‐EM reveals the dimensions, proximity, and overall organization of biological specimens in a near‐native state, avoiding artifacts of fixation and ...
M. Neal Waxham +3 more
wiley +1 more source
Engineering Science and Technology, an International JournalLimestone calcined clay cement (LC3) is one of prospective low-carbon ternary binders, developed by replacing 50 % of clinker with a combination of calcined clay (40 % kaolinite content) and limestone.
Khuram Rashid +3 more
doaj +1 more source
A compendium of extracellular vesicle biogenesis inhibitors: From bench to bedside
Interdisciplinary Medicine, EarlyView.This review explores a decade of research on extracellular vesicles (EVs), detailing their biogenesis and roles in health and disease. It emphasizes EVs' relevance for potential medical applications covering various conditions such as cancer, neurodegeneration, inflammation, and infectious diseases, bridging experimental findings with clinical ...
Stefano Vecchione +2 more
wiley +1 more source
缺氧条件下乙酰肝素酶抑制剂 PI-88 对人视网膜血管内皮细胞自噬的影响
Zhongshan Daxue xuebao. Yixue kexue ban, 2020 【目的】探讨乙酰肝素酶（Hpa）竞争性抑制剂PI-88在缺氧条件下对人视网膜血管内皮细胞（HREC）自噬水平的影响。【方法】以HREC为研究对象，设置3组：正常组，缺氧组（CoCl2处理的缺氧组）和实验组（CoCl2+PI-88组）。观察免疫荧光染色检测自噬体特异性标记物LC3蛋白的表达；Westernblot检测自噬相关蛋白LC3-Ⅰ与LC3-Ⅱ的表达；通过GFP-LC3腺病毒转染HREC，直接观察活细胞中由GFP-LC3标记的自噬水平。【结果】缺氧状态下，HREC内自噬标记蛋白LC3表达水平上调 ...
苑玉鑫 +5 more
doaj
Epirubicin Alters Pancreatic Autophagy and Insulin Synthesis Through a Zinc‐Dependent Mechanism
Journal of Applied Toxicology, EarlyView.ABSTRACT Epirubicin (EPI) can cause metabolic side effects, including chemotherapy‐related diabetes, partly through oxidative stress that disrupts zinc (Zn) homeostasis and impairs autophagy. This study investigated the effects of EPI on Zn regulation and autophagy in the pancreas, as well as the modulatory role of N‐acetylcysteine (NAC). Rats received
Ebru Afşar, Işıl Eranıl
wiley +1 more source
Journal of Applied Toxicology, EarlyView.ABSTRACT Bisphenol A (BPA) is a widely used industrial chemical found in polycarbonate plastics and epoxy resins and is recognized for its endocrine‐disrupting properties. Human exposure is common due to its presence in food packaging and everyday products. As BPA use has been restricted, structurally similar compounds such as BPS, BPB, BPAF, and BADGE
Nurbanu Zengin +4 more
wiley +1 more source
Optimizing Fabrication of Plasma‐Driven CuO Shell Over Porous Al2O3 Substrate to Meet Coating Issues
Journal of the Chinese Chemical Society, EarlyView.In situ Cu2O‐to‐CuO transformation during plasma electrolytic oxidation of aluminum alloys. ABSTRACT A plasma‐driven in situ conversion strategy was developed in which Cu2O nanoparticles introduced into an alkaline phosphate–hydroxide electrolyte undergo oxidative transformation to CuO within plasma micro‐discharge channels during plasma electrolytic ...
Sasithon Kaentown +5 more
wiley +1 more source