Results 71 to 80 of about 125,401 (357)
Venetoclax inhibits autophagy in chronic lymphocytic leukemia cells
Autophagy Reports, 2023 Venetoclax (VCX) is a BCL2 inhibitor approved for treating B cell-derived leukemia, including chronic lymphocytic leukemia (CLL). VCX’s role in apoptosis induction is well-defined, whereas its other mechanistic roles need to be clarified. Autophagy is an
Yongqiang Chen +6 more
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Atg8ylation as a general membrane stress and remodeling response
Cell Stress, 2021 The yeast Atg8 protein and its paralogs in mammals, mammalian Atg8s (mAtg8s), have been primarily appreciated for their participation in autophagy. However, lipidated mAtg8s, including the most frequently used autophagosomal membrane marker LC3B, are ...
Suresh Kumar, Jingyue Jia1, Vojo Deretic
doaj +1 more source
Semisynthesis of autophagy protein LC3 conjugates
Bioorganic & Medicinal Chemistry, 2017 Autophagy is a conserved catabolic process involved in the elimination of proteins, organelles and pathogens. Autophagosome formation is the key process in autophagy. Lipidated Atg8/LC3 proteins that are conjugated to phosphatidylethanolamine (PE) play a key role in autophagosome biogenesis.
Yang, Aimin +2 more
openaire +5 more sources
HeliyonLimestone calcined clay cement (LC3) is a recently developed binder with huge potential to reduce the clinker factor in cement and the environmental impact.
J. Mañosa +4 more
semanticscholar +1 more source
Nature Cell Biology, 2019 Traditionally viewed as an autodigestive pathway, autophagy also facilitates cellular secretion; however, the mechanisms underlying these processes remain unclear.
Andrew M. Leidal +16 more
semanticscholar +1 more source
Impairment of the autophagic flux in astrocytes intoxicated by trimethyltin [PDF]
, 2015 Autophagy is a lysosomal catabolic route for protein aggregates and damaged organelles which in different stress conditions, such as starvation, generally improves cell survival.
Catizone, Angiolina +8 more
core +2 more sources
Autophagy: A necessary process during the Trypanosoma cruzi life-cycle
Virulence, 2019 Autophagy is a well-conserved process of self-digestion of intracellular components. T. cruzi is a protozoan parasite with a complex life-cycle that involves insect vectors and mammalian hosts. Like other eukaryotic organisms, T.
Betiana Nebaí Salassa +1 more
doaj +1 more source
Phospholipid peroxidation inhibits autophagy via stimulating the delipidation of oxidized LC3-PE
Redox Biology, 2022 Phospholipid peroxidation of polyunsaturated fatty acids at the bis-allylic position drives ferroptosis. Here we identify a novel role for phospholipid peroxidation in the inhibition of autophagy.
Wen Li +18 more
semanticscholar +1 more source
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease
Hepatology, EarlyView., 2022 RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso +16 more
wiley +1 more source
Evaluation of the expression of LC3-II and BECLIN1 genes of autophagy pathway in patients with hematological malignancies [PDF]
Caspian Journal of Internal Medicine, 2023 Background: Autophagy is a pathway for the degradation of cytoplasmic components, which plays an essential role in various cellular and physiological processes, including cell renewal and survival, and immune responses.
Hossein Ayatollahi +6 more
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