Results 51 to 60 of about 125,252 (213)

A strategy to combine pathway-targeted low toxicity drugs in ovarian cancer. [PDF]

, 2015
Serous Ovarian Cancers (SOC) are frequently resistant to programmed cell death. However, here we describe that these programmed death-resistant cells are nonetheless sensitive to agents that modulate autophagy.
Bartakova, Alena, Davis, Mitzie-Ann, Delaney, Joe R, Haft, Carley, Lu, Dan, McCabe, Katelyn E, Patel, Chandni, Schlaepfer, David D, Stupack, Dwayne G, Tancioni, Isabelle, von Schalscha, Tami   +10 more
core   +2 more sources

Assessment of the dynamics of autophagy and apoptosis biomarkers in the acute period of ischemic stroke using flow cytometry

Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2022
The objective was to conduct a comparative analysis of the dynamics of biomarkers of apoptosis and autophagy in the eripheral blood of patients in the acute period of ischemic stroke (IS) and compare it with the dynamics of the severity of neurological ...
A. V. Lugovaya, Yu. V. Emanuel, A. V. Artemova, E. V. Semenova, V. V. Semenova   +4 more
doaj   +1 more source

AP2M1 mediates autophagy-induced CLDN2 (claudin 2) degradation through endocytosis and interaction with LC3 and reduces intestinal epithelial tight junction permeability

Autophagy, 2021
The intestinal epithelial tight junctions (TJs) provide barrier against paracellular permeation of lumenal antigens. Defects in TJ barrier such as increased levels of pore-forming TJ protein CLDN2 (claudin-2) is associated with inflammatory bowel disease.
A. S. Ganapathy, K. Saha, Eric Suchanec, Vikash Singh, A. Verma, G. Yochum, W. Koltun, M. Nighot, T. Ma, P. Nighot   +9 more
semanticscholar   +1 more source

Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis [PDF]

, 2017
Macrophages specialize in removing lipids and debris present in the atherosclerotic plaque. However, plaque progression renders macrophages unable to degrade exogenous atherogenic material and endogenous cargo including dysfunctional proteins and ...
Ali, Sahl, Ballabio, Andrea, Bhattacharya, Somashubhra, Crowley, Jan R, Dehestani, Babak, Diwan, Abhinav, Epelman, Slava, Evans, Trent D, Fan, Daping, Holloway, Karyn B, Javaheri, Ali, Micevych, Paul S, Razani, Babak, Schilling, Joel D, Sergin, Ismail, Song, Eric, Stokes, Carl J, Weihl, Conrad C, Zayed, Mohamed A, Zhang, Xiangyu   +19 more
core   +2 more sources

Efficiency and Energy Consumption of Partial Carbonation Process for CO₂ Capture from Natural Gas Combustion

Energies
Brazil has set a goal to reduce greenhouse gas (GHG) emissions, which is a significant opportunity to leverage calcium looping (CaL) technology for energy generation in natural gas power plants.
Rubens Coutinho Toledo, Caio Leandro de Moraes, Vinoth Thangarasu, João Andrade de Carvalho, Ivonete Avila   +4 more
doaj   +1 more source

Engineered Cementitious Composites (ECC) with limestone calcined clay cement (LC3)

Cement & Concrete Composites, 2020
Recent research have recognized that coupled use of calcined clay, limestone and cement clinker in concrete is viable to reduce environmental footprints at manufacture and to enhance material durability.
Duo Zhang, B. Jaworska, He-hua Zhu, K. Dahlquist, V. Li   +4 more
semanticscholar   +1 more source

Inhibition of autophagy by a small molecule through covalent modification of LC3.

Angewandte Chemie, 2021
The autophagic ubiquitin-like protein LC3 functions through interactions with LC3-interaction regions (LIRs) of other autophagy proteins including autophagy receptors, which stands out as a promising protein-protein interaction (PPI) target for the ...
C. Luo, Shi-jie Fan, Liyan Yue, W. Wan, Yuanyuan Zhang, Bidong Zhang, Chinatsu Otomo, Quanfu Li, Tingting Lin, Junchi Hu, Pan Xu, Mingrui Zhu, Hongrui Tao, Zhi-feng Chen, Lianchun Li, H. Ding, Zhiyi Yao, Junyan Lu, Yi Wen, Naixia Zhang, M. Tan, Kaixian Chen, Yuli Xie, T. Otomo, Bing Zhou, Hualiang Jiang, Yongjun Dang   +26 more
semanticscholar   +1 more source

Obatoclax and Paclitaxel Synergistically Induce Apoptosis and Overcome Paclitaxel Resistance in Urothelial Cancer Cells [PDF]

, 2018
Paclitaxel is a treatment option for advanced or metastatic bladder cancer after the failure of first-line cisplatin and gemcitabine, although resistance limits its clinical benefits.
Flores, M. Luz, Gasca Bellido, Jessica María, Japón Rodríguez, Miguel Ángel, Jiménez Guerrero, Rocío, Medina, Rafael, Pérez Valderrama, Begoña, Romero Portillo, Francisco, Tortolero García, María Dolores   +7 more
core   +1 more source

Effect of Vitamin D Deficiency and Supplementation in Lactation and Early Life on Allergic Airway Inflammation and the Expression of Autophagy-Related Genes in an Ovalbumin Mouse Model

Journal of Inflammation Research, 2021
Yan Zhou,1,* Yishu Xue,1,* Aihua Bao,1,* Lei Han,1 Wuping Bao,1 Chao Xia,2 Xue Tian,1 Min Zhang1 1Department of Respiratory and Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai ...
Zhou Y, Xue Y, Bao A, Han L, Bao W, Xia C, Tian X, Zhang M   +7 more
doaj  

Targeting quiescent leukemic stem cells using second generation autophagy inhibitors [PDF]

, 2019
In chronic myeloid leukemia (CML), tyrosine kinase inhibitor (TKI) treatment induces autophagy that promotes survival and TKI-resistance in leukemic stem cells (LSCs).
A Hamilton, A Kuma, AS Corbin, B Ronan, B Zhang, B Zhang, BJ Druker, C Bellodi, D Mahalingam, DJ Klionsky, DT Vogl, E Weisberg, F Liu, G Karsli-Uzunbas, JD Mancias, JY Guo, JY Guo, M Karvela, M Komatsu, M Mortensen, M Schemionek, MR Rosenfeld, MR Warr, MT Rosenfeldt, N Mizushima, P Rousselot, Q McAfee, R Bago, R Rangwala, R Rangwala, S Brenner, S Kimura, S Koschmieder, SM Graham, T Holyoake, TL Holyoake, TL Holyoake, TT Ho, V Kirkin, VW Rebecca, WE Dowdle, XH Ma, Z Tothova   +42 more
core   +2 more sources