Results 31 to 40 of about 102,219 (296)
The activation of KSHV lytic cycle blocks autophagy in PEL cells [PDF]
, 2015 This study confirms that autophagy is activated concomitantly with KSHV lytic cycle induction, and that autophagy inhibition by BECN1 knockdown reduces viral lytic gene expression.
CIRONE, Mara +7 more
core +1 more source
The aberrant expression of the mesenchymal variant of FGFR2 in the epithelial context inhibits autophagy [PDF]
, 2019 Signaling of the epithelial splice variant of fibroblast growth factor receptor 2 (FGFR2b) triggers both differentiation and autophagy, while the aberrant expression of the mesenchymal FGFR2c isoform in epithelial cells induces impaired differentiation ...
Belleudi, Francesca +4 more
core +1 more source
LC3-associated phagocytosis: a sorting mechanism for ubiquitinated membrane proteins?
Autophagy Reports, 2022 The process of LC3-associated phagocytosis (LAP) combines elements of phagocytosis and autophagy. LAP is involved in clearance of pathogens and cell debris, antigen presentation, and immune signaling. However, the mechanistic role of LAP is incompletely understood.
Femmy C. Stempels, Geert van den Bogaart
openaire +4 more sources
Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis [PDF]
, 2017 Macrophages specialize in removing lipids and debris present in the atherosclerotic plaque. However, plaque progression renders macrophages unable to degrade exogenous atherogenic material and endogenous cargo including dysfunctional proteins and ...
Ali, Sahl +19 more
core +2 more sources
Serratia marcescens ShlA Pore-Forming Toxin Is Responsible for Early Induction of Autophagy in Host Cells and Is Transcriptionally Regulated by RcsB [PDF]
, 2014 Serratia marcescens is a Gram-negative bacterium that thrives in a wide variety of ambient niches and interacts with an ample range of hosts. As an opportunistic human pathogen, it has increased its clinical incidence in recent years, being responsible ...
Di Venanzio, Gisela Andrea +2 more
core +1 more source
Detection of LC3‐Associated Phagocytosis (LAP) [PDF]
Current Protocols in Cell Biology, 2020 AbstractPhagocytes, notably macrophages, are critical sentinels of their environment, patrolling for and eradicating unwanted components. The ability of cells to process extracellular cargo in an appropriate manner is important for both clearance of the cargo and eventual return to homeostasis. Although the evolutionarily conserved pathway of autophagy
openaire +2 more sources
Distinct Lysosomal Network Protein Profiles in Parkinsonian Syndrome Cerebrospinal Fluid. [PDF]
, 2016 BackgroundClinical diagnosis of parkinsonian syndromes like Parkinson's disease (PD), corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP) is hampered by overlapping symptomatology and lack of diagnostic biomarkers, and definitive ...
Boman, Andrea +8 more
core +1 more source
Biomolecules, 2019 Many studies have focused on how autophagy plays an important role in intestinal homeostasis under pathological conditions. However, its role in the intestine during hibernation remains unclear.
Waseem Ali Vistro +9 more
doaj +1 more source
The blood proteome of imminent lung cancer diagnosis
Nature Communications, 2023 Identification of risk biomarkers may enhance early detection of smoking-related lung cancer. We measured between 392 and 1,162 proteins in blood samples drawn at most three years before diagnosis in 731 smoking-matched case-control sets nested within ...
The Lung Cancer Cohort Consortium (LC3)
doaj +1 more source
Düzce Tıp Fakültesi Dergisi, 2021 Aim: Acquired docetaxel (DOC) resistance of prostate cancer (PCa) is still a clinical problem. In addition to failure in chemotherapy treatment, it causes tumor recurrence.
Süleyman İlhan, Ferdi Oguz
doaj +1 more source