Results 31 to 40 of about 63,437 (218)
Antiretroviral Drugs Impact Autophagy: Opportunities for Drug Repurposing
Frontiers in Bioscience-LandmarkAutophagy is an evolutionarily conserved process in which intracellular macromolecules are degraded in a lysosomal-dependent manner. It is central to cellular energy homeostasis and to quality control of intracellular components.
Laura Cheney +3 more
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The Journal of Poultry Science, 2018 Autophagy, an intracellular bulk protein degradation system in skeletal muscle, is increased under catabolic conditions resulting in muscle atrophy. This study aimed to investigate the effects of insulin, insulin-like growth factor (IGF)-I, and amino ...
Kazuki Nakashima, Aiko Ishida
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Frontiers in Physiology, 2021 The cardioprotection of exercise preconditioning (EP) has been well documented. EP can be divided into two phases that are the induction of exercise preconditioning (IEP) and the protection of exercise preconditioning (PEP).
Dong-Feng Wan +3 more
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations
Advanced Biology, Volume 9, Issue 3, March 2025.Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio +11 more
wiley +1 more source
Yu Nu Compound Regulates Autophagy and Apoptosis Through mTOR in vivo and vitro
Diabetes, Metabolic Syndrome and Obesity, 2020 Caigu He,1 Guang Liu,1 Shuting Zhuang,2 Jialin Zhang,2 Yangtao Chen,1 Hetian Li,1 Zhengping Huang,1 Yanfang Zheng3 1Department of Histology and Embryology, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, People’s Republic ...
He C +7 more
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Localization of Autophagosome in Porcine Follicular Cumulus-oocyte Complex
Journal of Animal Reproduction and Biotechnology, 2017 Autophagy is an intracellular degradation and recycling system. Oocyte maturation is dynamic process, in which various proteins should be synthesized and degraded.
Seunghoon Lee +5 more
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E1-like activating enzyme Atg7 is preferentially sequestered into p62 aggregates via its interaction with LC3-I. [PDF]
PLoS ONE, 2013 p62 is constitutively degraded by autophagy via its interaction with LC3. However, the interaction of p62 with LC3 species in the context of the LC3 lipidation process is not specified.
Wentao Gao +3 more
doaj +1 more source
Advanced Optical Materials, EarlyView.Large Faraday rotation at room temperature is observed in thin films of discotic copper (Cu2+: 3d9) and vanadyl (VO2+: 3d1) enaminoketone complexes. The large Verdet constant originates from a high density of paramagnetic centers, metal‐ligand p−d hybridization and π orbitals involved in optical transitions (identified by DFT calculations), as well as ...
Karolina Łempicka‐Mirek +8 more
wiley +1 more source
The carboxyl-terminal amino acids render pro-human LC3B migration similar to lipidated LC3B in SDS-PAGE. [PDF]
PLoS ONE, 2013 LC3 is widely used marker for macroautophagy assays. After translation pro-LC3 is processed by Atg4 to expose C-terminal glycine residue for downstream conjugation reactions to accomplish the conversion of LC3-I to LC3-II. SDS-PAGE based Western blot (Wb)
Wei Wang +4 more
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