Results 11 to 20 of about 65,688 (210)

BAP31 Drives Cartilage Calcification through Disruption of Autophagosome-Lysosome Fusion in Osteoarthritis. [PDF]

Adv Sci (Weinh)
Mechanical stress activates BAP31 in chondrocytes. BAP31 competes with ATG14 for binding to STX17, disrupting the STX17–ATG14 complex required for autophagosome–lysosome fusion. The resultant autophagic flux blockade drives the generation of autophagy‐derived exosomes, which mediate pathological cartilage calcification in OA. Chondrocyte‐targeted BAP31
Xu ZH, Wang RX, He F, Liu Q, Li FY, Hui M, Shi YQ, Jiang Y, Li QH, Jing JW, Yu SB, Ma LT, Niu QN, Zhang M.   +13 more
europepmc   +2 more sources

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells. [PDF]

FEBS Open Bio
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Bonilla LE, Ledesma MM, Behr SA, Pibuel MA, Palanek ML, Grasso DH, Garcia MN, Garona J, Lompardía SL, Álvarez E, Papademetrio DL.   +10 more
europepmc   +2 more sources

Evaluating Autophagy in Preimplantation Embryos

Autophagy Reports, 2022
Autophagy is an essential cellular degradation pathway in the mammalian preimplantation embryo. In this review, the process of autophagy is outlined and its function pertaining to preimplantation embryos is discussed.
Zuleika C. L. Leung, Hailey L. M. Hunter, Basim Abu Rafea, Andrew J. Watson, Dean H. Betts   +4 more
doaj   +1 more source

Regulation of autophagy-related gene expressions by Trans-chalcone in the lungs of adult male rats [PDF]

مجله پزشکی دانشگاه علوم پزشکی تبریز
Background. Autophagy is responsible for maintaining cellular homeostasis by degrading and recycling macromolecules and unwanted intracellular components, such as damaged organelles.
Fatemeh Salehi Mazdeh, Elnaz Nakhjiri, Mohammad Reza Alipour, Parviz Shahabi, Elham Karimi-Sales   +4 more
doaj   +1 more source

Experimental Study on Mineral Dissolution and Carbonation Efficiency Applied to pH-Swing Mineral Carbonation for Improved CO₂ Sequestration

Energies, 2023
Mineral carbonation incurs high operating costs, as large amounts of chemicals and energy must be used in the process. Its implementation on an industrial scale requires reducing expenditures on chemicals and energy consumption.
Natália R. Galina, Gretta L. A. F. Arce, Mercedes Maroto-Valer, Ivonete Ávila   +3 more
doaj   +1 more source

Alpha-mangostin decreases high glucose-induced damage on human umbilical vein endothelial cells by increasing autophagic protein expression [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Diabetes is a chronic disorder that occurs as a result of impaired glucose metabolism. In hyperglycaemic states, the balance between oxidative stress and antioxidant enzymes is disrupted leading to oxidative damage and cell death.
Farhad Eisvand, Kasra Rezvani, Hossein Hosseinzadeh, Bibi Marjan Razavi   +3 more
doaj   +1 more source

p62/SQSTM1 droplets initiate autophagosome biogenesis and oxidative stress control

Molecular & Cellular Oncology, 2021
Selective autophagy contributes to the degradation of condensates, such as sequestosome 1-bodies, also called p62/SQSTM1-bodies. We showed that endogenous p62 forms gel-like structures, which serve as platforms for autophagosome formation and nuclear ...
Eeva-Liisa Eskelinen, Shun Kageyama, Masaaki Komatsu   +2 more
doaj   +1 more source

In Vivo Autophagy Up-Regulation of Small Intestine Enterocytes in Chinese Soft-Shelled Turtles during Hibernation

Biomolecules, 2019
Many studies have focused on how autophagy plays an important role in intestinal homeostasis under pathological conditions. However, its role in the intestine during hibernation remains unclear.
Waseem Ali Vistro, Yue Zhang, Xuebing Bai, Ping Yang, Yufei Huang, Wenjia Qu, Abdul Sattar Baloch, Ruizhi Wu, Imran Tarique, Qiusheng Chen   +9 more
doaj   +1 more source

Dosetaksel Dirençli Prostat Kanseri Hücrelerinde Timokinon Tarafından Otofajik Hücre Ölümünün İndüklenmesi

Düzce Tıp Fakültesi Dergisi, 2021
Aim: Acquired docetaxel (DOC) resistance of prostate cancer (PCa) is still a clinical problem. In addition to failure in chemotherapy treatment, it causes tumor recurrence.
Süleyman İlhan, Ferdi Oguz
doaj   +1 more source

ACSL4-Dependent Lysosomal Lipid Peroxidation Links WTAP-Mediated m⁶A Modification to Intervertebral Disc Degeneration. [PDF]

Adv Sci (Weinh)
IL‐1β upregulates the protein level of WTAP, which promotes the m6A modification of ACSL4 mRNA in an IGF2BP2‐dependent manner, thereby enhancing its stability. The increased ACSL4 drives lipid peroxidation, leading to lysosomal membrane permeabilization (LMP) and impaired mitophagy, which collectively accelerate intervertebral disc degeneration (IVDD).
Jia S, Gao X, Zhu L, Song H, Wu J, Chen S, Gao S, Zhang L, Meng C.   +8 more
europepmc   +2 more sources