Results 201 to 210 of about 93,186 (232)
Some of the next articles are maybe not open access.
International Journal of Quantitative Structure-Property Relationships, 2020
Rodent LD50 values have been used for almost a century as a measure of potential human toxicity from drugs and other chemicals. However, they have been found not, on the whole, to be good models for human toxicity. One reason for this could be the often-high variability of LD50 values.
openaire +1 more source
Rodent LD50 values have been used for almost a century as a measure of potential human toxicity from drugs and other chemicals. However, they have been found not, on the whole, to be good models for human toxicity. One reason for this could be the often-high variability of LD50 values.
openaire +1 more source
Pretreatment and heavy metal LD50 values
Toxicology and Applied Pharmacology, 1979Abstract LD50 values, with and without pretreatment with the same ion, have been determined in mice for intraperitoneal injection of salts of the ions Cd2+, Hg2+, Ag+, Tl+, Pd2+, Au+, Pt2+, Cu2+, Sn2+, Pt4+, and Zn2+. In the case of Cd2+ the previously reported increase in LD50 values subsequent to pretreatment was confirmed.
M M, Jones, J E, Schoenheit, A D, Weaver
openaire +2 more sources
JAMA: The Journal of the American Medical Association, 1985
In Reply.— I appreciate the letters by Dr Friedman and Dr Llaurado and respect their points of view. The Medical Research Modernization Committee, of which I am a chairman, does not take an either/or position on animal research or the use of animals in medical school teaching.
openaire +1 more source
In Reply.— I appreciate the letters by Dr Friedman and Dr Llaurado and respect their points of view. The Medical Research Modernization Committee, of which I am a chairman, does not take an either/or position on animal research or the use of animals in medical school teaching.
openaire +1 more source
Economical LD50 and Slope Determinations
Drug and Chemical Toxicology, 1983Many regulatory standards and guidelines required LD50 determinations and dose-response curve slopes, using at least 5 animals per sex per dosage level and at least 3 levels. In contrast, the current trend is to use as few animals as necessary for toxicological studies. The moving average method for calculation of the LD50 has been available since 1947
openaire +2 more sources
Trends in Pharmacological Sciences, 2001
The controversial LD50 Draize test, which determines the dose of a drug required to kill 50% of animals tested and is an indicator of acute oral toxicity, has recently been abolished by The Organisation for Economic Co-operation and Development (OECD).
openaire +1 more source
The controversial LD50 Draize test, which determines the dose of a drug required to kill 50% of animals tested and is an indicator of acute oral toxicity, has recently been abolished by The Organisation for Economic Co-operation and Development (OECD).
openaire +1 more source
Estimating LD50s without a computer
Parasitology Today, 1988Quantitative analysis of dose-related effects, such as mosquitoes killed by insecticide or parasites killed by a drug, usually involves estimating the dose which kills, on average, 50% of the subjects. This quantity is often termed the LD(50) (LD for lethal dose), or the ED(50) (ED for effective dose). Other specified response levels, such as the LD(90)
openaire +2 more sources
The LD50 test: Some considerations of precision
Toxicology Letters, 1982Substantial improvements in the statistical aspects of the LD50 test are possible. These include modifications to the design of the experiments (including the use of sequential methods) and the replacement of outdated techniques of statistical analysis with more appropriate methods. With such improvements, it would be possible to reduce appreciably the
D O, Chanter, R, Heywood
openaire +2 more sources
Canine left ventricular performance during LD50 endotoxemia
American Journal of Physiology-Heart and Circulatory Physiology, 1983Previous reports of the effect of endotoxin shock on cardiac performance have not achieved uniform results. These discrepancies have possibly been caused by the use of indices of cardiac performance that may have been sensitive to altered heart rate or preconditions of cardiac contraction as well as altered cardiac performance.
R D, Goldfarb +3 more
openaire +2 more sources
The 100‐Day LD50 Index of Captan
Acta Pharmacologica et Toxicologica, 1971Captan was given by gavage in a range of doses once daily for 100 days to young male albino rats. The oral LD50 (100 days) ± S. E. M. or daily dose which killed 50 % of rats over this period was found to be 0.92 ± 0.23 g/kg/day. The oral 100‐day LD50 index, or oral LD50 (100 days) expressed as a percentage of the acute oral LD50 (1 dose) was 7.3 ± 1.9 ...
E M, Boyd, E, Carsky
openaire +2 more sources