Results 21 to 30 of about 2,058,783 (273)

Spatial Cognition, Body Representation and Affective Processes: The Role of Vestibular Information beyond Ocular Reflexes and Control of Posture

open access: yesFrontiers in Integrative Neuroscience, 2014
A growing number of studies in humans demonstrate the involvement of vestibular information in tasks that are seemingly remote from well-known functions such as space constancy or postural control.
Fred W Mast   +6 more
doaj   +1 more source

Phosphoproteomics identifies microglial Siglec‐F inflammatory response during neurodegeneration

open access: yesMolecular Systems Biology, 2020
Alzheimer’s disease (AD) is characterized by the appearance of amyloid‐β plaques, neurofibrillary tangles, and inflammation in brain regions involved in memory. Using mass spectrometry, we have quantified the phosphoproteome of the CK‐p25, 5XFAD, and Tau
Nader Morshed   +12 more
doaj   +1 more source

Neural effects of propofol-induced unconsciousness and its reversal using thalamic stimulation

open access: yeseLife, 2021
The specific circuit mechanisms through which anesthetics induce unconsciousness have not been completely characterized. We recorded neural activity from the frontal, parietal, and temporal cortices and thalamus while maintaining unconsciousness in non ...
André M Bastos   +10 more
doaj   +1 more source

Structural plasticity of dendritic secretory compartments during LTP-induced synaptogenesis

open access: yeseLife, 2019
Long-term potentiation (LTP), an increase in synaptic efficacy following high-frequency stimulation, is widely considered a mechanism of learning. LTP involves local remodeling of dendritic spines and synapses.
Yelena D Kulik   +4 more
doaj   +1 more source

Functional imaging of visual cortical layers and subplate in awake mice with optimized three-photon microscopy

open access: yesNature Communications, 2019
Two-photon microscopy is a powerful tool for studying neuronal activity but cannot easily image deeper cortical layers. Here, the authors design a custom microscope for three-photon microscopy and use it to reveal response properties of layer 5, 6, and ...
Murat Yildirim   +3 more
doaj   +1 more source

Emergence of spatiotemporal invariance in large neuronal ensembles in rat barrel cortex.

open access: yesFrontiers in Neural Circuits, 2015
Invariant sensory coding is the robust coding of some sensory information (e.g. stimulus type) despite major changes in other sensory parameters (e.g. stimulus strength).
Nathan S Jacobs   +6 more
doaj   +1 more source

Differential involvement of hippocampal subfields in the relationship between Alzheimer's pathology and memory interference in older adults

open access: yesAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2023
Introduction We tested whether Alzheimer's disease (AD) pathology predicts memory deficits in non‐demented older adults through its effects on medial temporal lobe (MTL) subregional volume. Methods Thirty‐two, non‐demented older adults with cerebrospinal
Jenna N. Adams   +12 more
doaj   +1 more source

FMRP regulates an ethanol-dependent shift in GABABR function and expression with rapid antidepressant properties

open access: yesNature Communications, 2016
Alcohol is thought to lead to neuroadaptive changes, although the underlying molecular mechanisms are unclear. Here, the authors find ethanol treatment alters GABAB-receptor expression via fragile-X mental retardation protein in mice, leading to ...
Sarah A. Wolfe   +10 more
doaj   +1 more source

Impaired Dendritic Expression and Plasticity of h-Channels in the fmr1−/y Mouse Model of Fragile X Syndrome

open access: yesCell Reports, 2012
Despite extensive research into both synaptic and morphological changes, surprisingly little is known about dendritic function in fragile X syndrome (FXS).
Darrin H. Brager   +2 more
doaj   +1 more source

Protective Effects of Crocus Sativus L. Extract and Crocin against Chronic-Stress Induced Oxidative Damage of Brain, Liver and Kidneys in Rats [PDF]

open access: yesAdvanced Pharmaceutical Bulletin, 2014
Purpose: Chronic stress has been reported to induce oxidative damage of the brain. A few studies have shown that Crocus Sativus L., commonly known as saffron and its active constituent crocin may have a protective effect against oxidative stress.
Ahmad Reza Bandegi   +3 more
doaj   +1 more source

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